homeostasis/metabolism
• homozygotes are viable, healthy and show no obvious neurological abnormalities, such as ataxia, up to 18 months of age
• however, chow-fed homozygotes exhibit a >90% reduction of alpha-tocopherol levels in plasma and most tissues
• notably, in liver, adipose tissue, adrenal gland, and aorta, alpha-tocopherol levels are only 15-35% of wild-type levels
|
reproductive system
• female homozygotes are infertile whereas male homozygotes exhibit normal fertility
• vitamin E supplementation (1,000 units/kg of diet) completely reverses the fertility defect in female mutants
|
cardiovascular system
N |
• normolipidemic homozygotes exhibit no spontaneous atherosclerosis; however, vitamin E deficiency appears to increase the severity of atherosclerotic lesions in a atherosclerosis-susceptible setting e.g. Apoe deficiency
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
familial isolated deficiency of vitamin E | DOID:0090028 |
OMIM:277460 |
J:66419 |