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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cr2tm1Hmo
targeted mutation 1, Hector Molina
MGI:1932568
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cr2tm1Hmo/Cr2tm1Hmo B6.129S7-Cr2tm1Hmo MGI:3715644
hm2
 		Cr2tm1Hmo/Cr2tm1Hmo involves: 129S7/SvEvBrd MGI:2175790
hm3
 		Cr2tm1Hmo/Cr2tm1Hmo involves: 129S7/SvEvBrd * C57BL/6 MGI:4356058


Genotype
MGI:3715644
hm1
Allelic
Composition		 Cr2tm1Hmo/Cr2tm1Hmo
Genetic
Background		 B6.129S7-Cr2tm1Hmo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cr2tm1Hmo mutation (1 available); any Cr2 mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased susceptibility to injury ( J:78241 )
• reduced mucosal injury and little change in villus height in intestines after mesenteric ischemia and reperfusion
• no significant depositions of IgM, IgG or C3 observed
• pretreatment with IgM or a combination of IgM and IgG restores injury response to ischemia reperfusion

renal/urinary system
renal/urinary system phenotype ( J:103238 )
N
• no significant effect on renal ischemia reperfusion injury

immune system
increased susceptibility to bacterial infection ( J:94855 )
• mice are more susceptible to pneumococcal infection than controls
• when challenged with a PspA- bacterial strain, mice have a 10-fold higher burden 4 hours after infection
• mice on average die 3.5 days after infection compared to none in wild-type controls
• only 20% of mice survive infection while all wild-type controls survive
• only 12% of mice survive infection with a more virulent PspA+ strain compared to 42% of controls




Genotype
MGI:2175790
hm2
Allelic
Composition		 Cr2tm1Hmo/Cr2tm1Hmo
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cr2tm1Hmo mutation (1 available); any Cr2 mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased IgG level ( J:35112 )
• although serum levels of IgG in general are normal in unimmunized mice, a significantly reducted response of IgG1 occurs after immunization with T-cell dependent antigen
• a significantly reducted response of IgG2a, IgG2b and IgG3 occurs after immunization with T-cell dependent antigen
• secondary response is increased several fold over primary response but is still significantly below that of controls
decreased IgM level ( J:35112 )
• although serum levels are normal in unimmunized mice, a significant reduction in response occurs after immunization with T-cell dependent antigen
• secondary response is increased several fold over primary response but is still significantly below that of controls

hematopoietic system
decreased IgG level ( J:35112 )
• although serum levels of IgG in general are normal in unimmunized mice, a significantly reducted response of IgG1 occurs after immunization with T-cell dependent antigen
• a significantly reducted response of IgG2a, IgG2b and IgG3 occurs after immunization with T-cell dependent antigen
• secondary response is increased several fold over primary response but is still significantly below that of controls
decreased IgM level ( J:35112 )
• although serum levels are normal in unimmunized mice, a significant reduction in response occurs after immunization with T-cell dependent antigen
• secondary response is increased several fold over primary response but is still significantly below that of controls




Genotype
MGI:4356058
hm3
Allelic
Composition		 Cr2tm1Hmo/Cr2tm1Hmo
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cr2tm1Hmo mutation (1 available); any Cr2 mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal memory B cell differentiation ( J:151991 )
• bone marrow chimeric mice have reduced ability to generate memory B cells in response to low-dose antigen
abnormal B cell physiology ( J:151991 )
• B cells fail to internalize complement coated immune complexes
• bone marrow chimeric mice containing mutant B cells fail to produce antigen-specific antibodies
abnormal class switch recombination ( J:151991 )
• bone marrow chimeric mice have reduced ability in class switch recombination in response to low dose antigen
abnormal B cell activation ( J:151991 )
• B cells fail to react to sub-optimal doses of antigen coated in C3 complement

hematopoietic system
abnormal memory B cell differentiation ( J:151991 )
• bone marrow chimeric mice have reduced ability to generate memory B cells in response to low-dose antigen
abnormal B cell physiology ( J:151991 )
• B cells fail to internalize complement coated immune complexes
• bone marrow chimeric mice containing mutant B cells fail to produce antigen-specific antibodies
abnormal class switch recombination ( J:151991 )
• bone marrow chimeric mice have reduced ability in class switch recombination in response to low dose antigen
abnormal B cell activation ( J:151991 )
• B cells fail to react to sub-optimal doses of antigen coated in C3 complement




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory