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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Roratm1Vgi
targeted mutation 1, Vincent Giguere
MGI:1933211
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Roratm1Vgi/Roratm1Vgi involves: 129S1/Sv * 129X1/SvJ * ICR MGI:2174719


Genotype
MGI:2174719
hm1
Allelic
Composition		 Roratm1Vgi/Roratm1Vgi
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Roratm1Vgi mutation (0 available); any Rora mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:46140 )
• mice die between 24 to 28 days after birth

nervous system
decreased Purkinje cell number ( J:46140 )
• Purkinje cells are significantly reduced in numbers
ectopic Purkinje cell ( J:46140 )
• cells form a diffuse layer
small cerebellum ( J:46140 )
• cerebella of 21 old day mice are several times smaller

behavior/neurological
tremors ( J:46140 )
• tremors are observed in all mice
impaired balance ( J:46140 )
• is observed in mice before they die




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory