All Phenotypes Shc2<tm1Paw> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Shc2^tm1Paw
targeted mutation 1, Tony Pawson
MGI:1933344

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Shc2^tm1Paw/Shc2^tm1Paw	involves: 129	MGI:3037022
cx2	Shc2^tm1Paw/Shc2^tm1Paw Shc3^tm1Paw/Shc3^tm1Paw	involves: 129	MGI:3037024

Allelic Composition	Shc2^tm1Paw/Shc2^tm1Paw
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shc2^tm1Paw mutation (2 available); any Shc2 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal sensory neuron morphology ( J:66508 )

• reduced cross sectional area of the dorsal cutaneous nerve

• loss of large caliber myelinated axons and unmyelinated axons in dorsal cutaneous nerve

abnormal nociceptor morphology ( J:66508 )

• reduction but not total elimination of all peptidergic and nonpeptidergic sensory nerves associated with nociception

abnormal dorsal root ganglion morphology ( J:66508 )

• 32% reduction in myelinated axons in the dorsal root ganglia of L4 and T13

small dorsal root ganglion ( J:66508 )

• 38% loss of sensory neurons

Allelic Composition	Shc2^tm1Paw/Shc2^tm1Paw Shc3^tm1Paw/Shc3^tm1Paw
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shc2^tm1Paw mutation (2 available); any Shc2 mutation (33 available)
Shc3^tm1Paw mutation (1 available); any Shc3 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype