Phenotypes associated with this allele

• Allele Symbol: Shc3^tm1Paw
• Allele Name: targeted mutation 1, Tony Pawson
• Allele ID: MGI:1933356
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Shc3^tm1Paw/Shc3^tm1Paw	involves: 129	MGI:3037023
cx2	Shc2^tm1Paw/Shc2^tm1Paw Shc3^tm1Paw/Shc3^tm1Paw	involves: 129	MGI:3037024

Genotype
MGI:3037023

hm1

• Allelic Composition: Shc3^tm1Paw/Shc3^tm1Paw
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:66508 )

N • vestibular and spiral ganglia appeared to be normal

N • no significant losses in myelination

N • no significant losses in sensory neurons

N • no effect on dorsal cutaneous nerves

Genotype
MGI:3037024

cx2

• Allelic Composition: Shc2^tm1Paw/Shc2^tm1Paw; Shc3^tm1Paw/Shc3^tm1Paw
• Genetic Background: involves: 129

nervous system

small superior cervical ganglion ( J:66508 )

• 33% loss of superior cervical ganglion neurons but not in singly homozygouys mice

• loss occurs after E13.5 but before birth

• preganglionic innervation normal

abnormal sensory neuron morphology ( J:66508 )

• reduced cross sectional area of the dorsal cutaneous nerve

• loss of large caliber myelinated axons and unmyelinated axons in dorsal cutaneous nerve

abnormal nociceptor morphology ( J:66508 )

• reduction but not total elimination of all peptidergic and nonpeptidergic sensory nerves associated with nociception

abnormal dorsal root ganglion morphology ( J:66508 )

• 32% reduction in myelinated axons in the dorsal root ganglia of L4 and T13

small dorsal root ganglion ( J:66508 )

• 38% loss of sensory neurons