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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sp5tm1Rbe
targeted mutation 1, Rosa Beddington
MGI:1933409
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sp5tm1Rbe/Sp5tm1Rbe involves: 129P2/Ola * C57BL/6J MGI:3029241
cx2
 		Sp5tm1Rbe/Sp5tm1Rbe
T/T+ 		involves: 129P2/Ola * C57BL/6J MGI:3029242


Genotype
MGI:3029241
hm1
Allelic
Composition		 Sp5tm1Rbe/Sp5tm1Rbe
Genetic
Background		 involves: 129P2/Ola * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sp5tm1Rbe mutation (0 available); any Sp5 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:65743 )
• mice appear normal up to 1.5 years of age and are fertile




Genotype
MGI:3029242
cx2
Allelic
Composition		 Sp5tm1Rbe/Sp5tm1Rbe
T/T+
Genetic
Background		 involves: 129P2/Ola * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sp5tm1Rbe mutation (0 available); any Sp5 mutation (15 available)
T mutation (22 available); any T mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
decreased caudal vertebrae number ( J:65743 )
• majority of tails are comprised of fewer than 8 vertebrae

skeleton
decreased caudal vertebrae number ( J:65743 )
• majority of tails are comprised of fewer than 8 vertebrae
abnormal lumbar vertebrae morphology ( J:65743 )
• lumbar vertebrae defect consisting of an imperfect fusion of the two ventral halves of the vertebra, resulting in an abnormal centrum




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory