Analysis Tools|
Allele Symbol Allele Name Allele ID |
Lfngtm1Grid targeted mutation 1, Tom Gridley MGI:1933734 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at P4, significantly enhanced sprouting and increased vascular area is observed in the retina
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• at P4, significantly enhanced sprouting and increased vascular area is observed in the retina
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• some neonatal lethality due to respiratory difficulties related to a malformed rib cage
• less severely affected mice survive
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• defects in somite formation after E8.5
• size and shape are irregular
• metameric pattern is not maintained
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• number of ribs attached to the sternum is reduced
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• some ribs are detached from the vertebral column
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• reduced number of ribs
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• regular metameric pattern of vertebrae is disrupted
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• reduced number of cervical vertebrae
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• some, but not all, females are infertile
(J:48810)
• genetic background may contribute to whether or not mice are fertile
(J:105928)
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| N |
• at E18, homozygotes display no alterations in cochlear hair cell number or patterning relative to wild-type or heterozygous mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• surprisingly, at E18, double homozygotes display total suppression of the increase in number of hair cells in the IHC row observed in single Jag2tm1Grid homozygotes; this effect is specific for IHCs
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• at E18, double homozygotes display disrupted patterning of the OHC rows, similar to single Jag2tm1Grid homozygotes
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• at E18, double homozygotes display generation of supernumerary OHCs, similar to single Jag2tm1Grid homozygotes
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• surprisingly, at E18, double homozygotes display total suppression of the increase in number of hair cells in the IHC row observed in single Jag2tm1Grid homozygotes; this effect is specific for IHCs
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• at E18, double homozygotes display disrupted patterning of the OHC rows, similar to single Jag2tm1Grid homozygotes
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• at E18, double homozygotes display generation of supernumerary OHCs, similar to single Jag2tm1Grid homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E18, these mutants display only partial suppression of the Jag2tm1Grid homozygous mutant phenotype in the IHC row
• in these mice, regions of two rows of IHCs are interspersed with regions of a single row of IHCs
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• at E18, these mutants display only partial suppression of the Jag2tm1Grid homozygous mutant phenotype in the IHC row
• in these mice, regions of two rows of IHCs are interspersed with regions of a single row of IHCs
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• phenotypes of double homozygotes were identical to those of mice homozygous for Lfngtm1Grid only
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• some ribs are detached from the vertebral column
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• regular metameric pattern of vertebrae is disrupted
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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