All Phenotypes Lfng<tm1Rjo> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lfng^tm1Rjo
targeted mutation 1, Randy L Johnson
MGI:1933737

Summary

17 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lfng^tm1Rjo/Lfng^tm1Rjo	B6.129S7-Lfng^tm1Rjo	MGI:3850730
hm2	Lfng^tm1Rjo/Lfng^tm1Rjo	either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S7/SvEvBrd * C57BL/6J * FVB/N)	MGI:3777244
hm3	Lfng^tm1Rjo/Lfng^tm1Rjo	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/NJ	MGI:3849433
hm4	Lfng^tm1Rjo/Lfng^tm1Rjo	involves: 129S7/SvEvBrd	MGI:4420251
hm5	Lfng^tm1Rjo/Lfng^tm1Rjo	involves: 129S7/SvEvBrd * C57BL/6	MGI:3618278
hm6	Lfng^tm1Rjo/Lfng^tm1Rjo	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3849434
cx7	Lfng^tm1Rjo/Lfng^tm1Rjo Mfng^tm1Cjg/Mfng^tm1Cjg	B6.Cg-Lfng^tm1Rjo Mfng^tm1Cjg	MGI:4360090
cx8	Lfng^tm1Rjo/Lfng^tm1Rjo Mfng^tm1Seco/Mfng^tm1Seco	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/NJ	MGI:3849431
cx9	Lfng^tm1Rjo/Lfng^tm1Rjo Mfng^tm1Seco/Mfng^tm1Seco Rfng^tm1Tfv/Rfng^tm1Tfv	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/NJ	MGI:3849432
cx10	Lfng^tm1Rjo/Lfng^tm1Rjo Mesp2^{tm15.1(Lfng)Ysa}/Mesp2⁺	involves: 129S7/SvEvBrd	MGI:4454336
cx11	Lfng^tm1Rjo/Lfng^tm1Rjo Tg(Hes7-Lfng,-EGFP)#Ysa/0	involves: 129S7/SvEvBrd	MGI:4454337
cx12	Lfng^tm1Rjo/Lfng^tm1Rjo Ripply2^tm1.1Ysa/Ripply2^tm1.1Ysa	involves: 129S7/SvEvBrd * C57BL/6 * CBA * ICR	MGI:3758871
cx13	Lfng^tm1Rjo/Lfng^tm1Rjo Tg(Lfng-LFNG)1Dihz/0	involves: 129S7/SvEvBrd * C57BL/6J * CBA	MGI:4420255
cx14	Lfng^tm1Rjo/Lfng^tm1Rjo Tg(Lfng-LFNG)2Dihz/?	involves: 129S7/SvEvBrd * C57BL/6J * CBA	MGI:4420256
cx15	Lfng^tm1Rjo/Lfng^tm1Rjo Tg(Lfng*-LFNG)2Dihz/0	involves: 129S7/SvEvBrd * C57BL/6J * CBA	MGI:4420254
cx16	Lfng^tm1Rjo/Lfng^tm1Rjo Tg(Lfng*-LFNG)1Dihz/0	involves: 129S7/SvEvBrd * C57BL/6J * CBA	MGI:4420253
cx17	Lfng^tm1Rjo/Lfng^tm1Rjo Tg(Lfng-LFNG)1Dihz/Tg(Lfng-LFNG)1Dihz	involves: 129S7/SvEvBrd * C57BL/6J * CBA	MGI:4420252

Allelic Composition	Lfng^tm1Rjo/Lfng^tm1Rjo
Genetic Background	B6.129S7-Lfng^tm1Rjo

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lfng^tm1Rjo mutation (0 available); any Lfng mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal multifidus muscle morphology ( J:324821 )

• anterograde shifts of the cranial and caudal borders of the multifidus muscles in 13 of 15 mice

• in 6 of 15 mice there is a unilateral or bilateral anterograde shift of the cranial multifidus border to C2 or C1 rather than T2

• results in the addition of new muscle segments with novel insertion sites craniad to T2

• posterograde shifts of the cranial multifidus border are also seen with cranial insertion points at only T6 or T9 rather than T2

skeleton

abnormal rib morphology ( J:324821 )

• fusions and bifurcations resulting in highly variable intercostal distances

rib bifurcation ( J:324821 )

rib fusion ( J:324821 )

abnormal vertebrae morphology ( J:324821 )

• widespread vertebral defects at almost all vertebral levels

• defects are more severe in the lumbar region than in the thoracic and cervical regions

vertebral fusion ( J:324821 )

• fusions are seen

• however, the spinous process at T2 is present and distinct

Allelic Composition	Lfng^tm1Rjo/Lfng^tm1Rjo
Genetic Background	either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S7/SvEvBrd * C57BL/6J * FVB/N)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lfng^tm1Rjo mutation (0 available); any Lfng mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:131837 )

• survival of homozygotes postnatally is only rarely observed

embryo

abnormal rostral-caudal patterning of the somites ( J:131837 )

• at E9.5, little compartmentalization of somites is observed, with rostral and caudal cells appearing mixed

• at E10.5, somites in thoracic region fail to compartmentalize, maintaining an unsegmented pattern and this continues during secondary body formation

skeleton

rib fusion ( J:131837 )

• in thoracic region, multiple rib fusions are observed

abnormal thoracic vertebrae morphology ( J:131837 )

• thoracic vertebrae are disorganized; vertebral condensations are irregular and misaligned

abnormal lumbar vertebrae morphology ( J:131837 )

• vertebral disorganization extends through lumbar region; vertebral condensations are irregular and misaligned

abnormal sacral vertebrae morphology ( J:131837 )

• vertebral disorganization extends through sacral region; vertebral condensations are irregular and misaligned

limbs/digits/tail

short tail ( J:131837 )

• tail is severely truncated

reproductive system

male infertility ( J:131837 )

• males surviving to adulthood are sterile

Allelic Composition	Lfng^tm1Rjo/Lfng^tm1Rjo
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/NJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lfng^tm1Rjo mutation (0 available); any Lfng mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:149312 )

• fewer than expected are found at weaning however survivors are viable and fertile

postnatal lethality, incomplete penetrance ( J:149312 )

• fewer than expected are found at weaning

• Background Sensitivity: survival is improved compared to mice on a mixed C57BL/6J and 129 background

skeleton

decreased caudal vertebrae number ( J:149312 )

abnormal rib morphology ( J:149312 )

limbs/digits/tail

decreased caudal vertebrae number ( J:149312 )

Allelic Composition	Lfng^tm1Rjo/Lfng^tm1Rjo
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lfng^tm1Rjo mutation (0 available); any Lfng mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Regional and dose-dependent rescue of the Lfng phenotype by transgenic expression in the stripe domain

mortality/aging

decreased survivor rate ( J:155378 )

• relative viability compared to wild-type controls is 9%

preweaning lethality, incomplete penetrance ( J:155378 )

• most die before weaning

skeleton

absent caudal vertebrae ( J:155378 )

• have either 1 or 0 tail vertebrae

decreased caudal vertebrae number ( J:155378 )

• have either 1 or 0 tail vertebrae

abnormal sclerotome morphology ( J:155378 )

• at E10.5 - E11.5, sclerotomes cranial to the hindlimb buds are fused and borders never become as visible as in wild-type controls

• at E11.5 the PAX1 domain in the tail is thicker indicating limited formation of the scleretome

embryo

abnormal rostral-caudal axis patterning ( J:123846 )

• embryos are rostralized,compared to wild-type

caudal body truncation ( J:155378 )

• axial extension ceases around E10.5 resulting in a truncated tail

abnormal somite development ( J:155378 )

• somites become increasingly irregular towards the end of the tail

• however, segmentation in the sacrum and adjacent tail area is regular

limbs/digits/tail

absent caudal vertebrae ( J:155378 )

• have either 1 or 0 tail vertebrae

decreased caudal vertebrae number ( J:155378 )

• have either 1 or 0 tail vertebrae

short tail ( J:155378 )

• unsegmented tail stump

Allelic Composition	Lfng^tm1Rjo/Lfng^tm1Rjo
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lfng^tm1Rjo mutation (0 available); any Lfng mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, incomplete penetrance ( J:146621 )

• homozygotes die late in embryonic lethality

skeleton

skeleton phenotype ( J:48859 )

abnormal axial skeleton morphology ( J:48859 )

rib fusion ( J:48859 )

abnormal vertebrae development ( J:48859 )

• incompletely formed vertebrae

abnormal vertebral body development ( J:48859 )

vertebral fusion ( J:48859 )

embryo

abnormal embryo development ( J:48859 )

abnormal rostral-caudal patterning of the somites ( J:48859 )

• failure of caudal and rostral spatial definition of half-somites

abnormal embryonic hematopoiesis ( J:146621 )

• when mutant fetal liver cells is mixed 1:1 with wild-type bone marrow and transferred into lethally irradiated hosts, there is a slight reduction in the number of marginal zone B cells generated compared to controls

reproductive system

abnormal female reproductive system morphology ( J:96967 )

• reproductive tracts of 4 and 7 week old null mice are smaller than heterozygous littermates

abnormal ovarian follicle morphology ( J:96967 )

• sexually mature mice had normal follicles of all sizes and abnormal follicles

abnormal ovarian folliculogenesis ( J:96967 )

impaired ovarian folliculogenesis ( J:96967 )

small ovary ( J:96967 )

• ovaries of 4 and 7 week old null mice are smaller than heterozugous littermates

abnormal gametogenesis ( J:96967 )

abnormal oocyte morphology ( J:96967 )

• after induced ovulation and fertilization, only 9.7% of eggs became 2-cell embryos compared to 48.8% of controls

• only 2% of embryos became 4 to 8 cell embryos and none reached the blastocyst stage compared to 31.4% of controls that reached blastocysts stage

abnormal female meiosis ( J:96967 )

• oocytes do not complete meiotic maturation

female infertility ( J:96967 )

• all females found infertile due to defects in meiotic maturation

endocrine/exocrine glands

abnormal ovarian follicle morphology ( J:96967 )

• sexually mature mice had normal follicles of all sizes and abnormal follicles

abnormal ovarian folliculogenesis ( J:96967 )

impaired ovarian folliculogenesis ( J:96967 )

small ovary ( J:96967 )

• ovaries of 4 and 7 week old null mice are smaller than heterozugous littermates

hematopoietic system

abnormal embryonic hematopoiesis ( J:146621 )

cellular

abnormal oocyte morphology ( J:96967 )

• after induced ovulation and fertilization, only 9.7% of eggs became 2-cell embryos compared to 48.8% of controls

• only 2% of embryos became 4 to 8 cell embryos and none reached the blastocyst stage compared to 31.4% of controls that reached blastocysts stage

abnormal female meiosis ( J:96967 )

• oocytes do not complete meiotic maturation

Allelic Composition	Lfng^tm1Rjo/Lfng^tm1Rjo
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lfng^tm1Rjo mutation (0 available); any Lfng mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:149312 )

• mice rarely survive postnatally

• Background Sensitivity: survival is reduced compared to mice on a mixed C57BL/6, 129, and FVB/NJ background

Allelic Composition	Lfng^tm1Rjo/Lfng^tm1Rjo Mfng^tm1Cjg/Mfng^tm1Cjg
Genetic Background	B6.Cg-Lfng^tm1Rjo Mfng^tm1Cjg

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lfng^tm1Rjo mutation (0 available); any Lfng mutation (32 available)
Mfng^tm1Cjg mutation (0 available); any Mfng mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal embryonic hematopoiesis ( J:146621 )

• when mutant fetal liver cells is transferred into lethally irradiated hosts, there is a 50% reduction in the number of marginal zone B cells generated compared to controls

hematopoietic system

abnormal embryonic hematopoiesis ( J:146621 )

• when mutant fetal liver cells is transferred into lethally irradiated hosts, there is a 50% reduction in the number of marginal zone B cells generated compared to controls

Allelic Composition	Lfng^tm1Rjo/Lfng^tm1Rjo Mfng^tm1Seco/Mfng^tm1Seco
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/NJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lfng^tm1Rjo mutation (0 available); any Lfng mutation (32 available)
Mfng^tm1Seco mutation (1 available); any Mfng mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:149312 )

• fewer than expected are found at weaning however survivors are viable and fertile

postnatal lethality, incomplete penetrance ( J:149312 )

• fewer than expected are found at weaning

• reduction in numbers found at weaning is not greater than that of Lfng^tm1Rjo single homozygous littermates

skeleton

abnormal skeleton morphology ( J:149312 )

• skeleton phenotype is not significantly different from that of Lfng^tm1Rjo single homozygous mice

decreased caudal vertebrae number ( J:149312 )

abnormal rib morphology ( J:149312 )

limbs/digits/tail

decreased caudal vertebrae number ( J:149312 )

Allelic Composition	Lfng^tm1Rjo/Lfng^tm1Rjo Mfng^tm1Seco/Mfng^tm1Seco Rfng^tm1Tfv/Rfng^tm1Tfv
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/NJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:149312 )

• fewer than expected are found at weaning however survivors are viable and fertile

postnatal lethality, incomplete penetrance ( J:149312 )

• fewer than expected are found at weaning

• reduction in numbers found at weaning is not greater than that of Lfng^tm1Rjo single homozygous littermates

skeleton

abnormal skeleton morphology ( J:149312 )

• skeleton phenotype is not significantly different from that of Lfng^tm1Rjo single homozygous mice

decreased caudal vertebrae number ( J:149312 )

abnormal rib morphology ( J:149312 )

limbs/digits/tail

limbs/digits/tail phenotype ( J:149312 )

N	• unlike in chick embryo experiments, no limb abnormalities are seen

decreased caudal vertebrae number ( J:149312 )

Allelic Composition	Lfng^tm1Rjo/Lfng^tm1Rjo Mesp2^{tm15.1(Lfng)Ysa}/Mesp2⁺
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lfng^tm1Rjo mutation (0 available); any Lfng mutation (32 available)
Mesp2^{tm15.1(Lfng)Ysa} mutation (0 available); any Mesp2 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal somite development ( J:159983 )

• the segmental morphology in the developing embryos is similar to that in Lfng^tm1Rjo single homozygotes

abnormal dorsal-ventral polarity of the somites ( J:159983 )

• abnormal vertebral morphology along the anteroposterior axis as is seen in Lfng^tm1Rjo single homozygotes

Allelic Composition	Lfng^tm1Rjo/Lfng^tm1Rjo Tg(Hes7-Lfng,-EGFP)#Ysa/0
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lfng^tm1Rjo mutation (0 available); any Lfng mutation (32 available)
Tg(Hes7-Lfng,-EGFP)#Ysa mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryo phenotype ( J:159983 )

N	• no defects in somite segmentation are detected unlike in null mice not carrying the transgene

skeleton

skeleton phenotype ( J:159983 )

N	• no defects are detected in the skeletal system unlike in null mice not carrying the transgene

Allelic Composition	Lfng^tm1Rjo/Lfng^tm1Rjo Ripply2^tm1.1Ysa/Ripply2^tm1.1Ysa
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * CBA * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lfng^tm1Rjo mutation (0 available); any Lfng mutation (32 available)
Ripply2^tm1.1Ysa mutation (1 available); any Ripply2 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal rostral-caudal axis patterning ( J:123846 )

• embryos show a more rostralized phenotype than Ripply2-null embryos

skeleton

absent vertebral pedicles ( J:123846 )

• pedicals of the neural arches are almost completely absent

Allelic Composition	Lfng^tm1Rjo/Lfng^tm1Rjo Tg(Lfng-LFNG)1Dihz/0
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lfng^tm1Rjo mutation (0 available); any Lfng mutation (32 available)
Tg(Lfng-LFNG)1Dihz mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Regional and dose-dependent rescue of the Lfng phenotype by transgenic expression in the stripe domain

mortality/aging

decreased survivor rate ( J:155378 )

• survival is improved compared to null mice not carrying the transgene but still less than that of wild-type controls

• relative viability compared to wild-type controls is 33%

skeleton

increased rib number ( J:155378 )

• many mice have extra pair of true ribs

increased thoracic vertebrae number ( J:155378 )

• many mice have extra rib-bearing thoracic vertebrae

decreased lumbar vertebrae number ( J:155378 )

• many mice are missing a lumbar vertebra

vertebral transformation ( J:155378 )

• many mice have extra rib-bearing thoracic vertebra indicating homeotic transformation

reproductive system

male infertility ( J:155378 )

Allelic Composition	Lfng^tm1Rjo/Lfng^tm1Rjo Tg(Lfng-LFNG)2Dihz/?
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lfng^tm1Rjo mutation (0 available); any Lfng mutation (32 available)
Tg(Lfng-LFNG)2Dihz mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Adult tail phenotype of Lfng^tm1Rjo/Lfng^tm1Rjo and Hes7^tm1.1Dihz/Hes7^tm1.1Dihz mice and the effect on the Lfng tail phenotype by transgenic expression in the stripe domain

mortality/aging

decreased survivor rate ( J:155378 )

• survival is improved compared to null mice not carrying the transgene but still less than that of wild-type controls

• relative viability compared to wild-type controls is 68%

skeleton

increased rib number ( J:155378 )

• many mice have extra pair of true ribs

increased thoracic vertebrae number ( J:155378 )

• many mice have extra rib-bearing thoracic vertebrae

decreased lumbar vertebrae number ( J:155378 )

• many mice are missing a lumbar vertebra

vertebral transformation ( J:155378 )

• many mice have extra rib-bearing thoracic vertebra indicating homeotic transformation

reproductive system

male infertility ( J:155378 )

Allelic Composition	Lfng^tm1Rjo/Lfng^tm1Rjo Tg(Lfng*-LFNG)2Dihz/0
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lfng^tm1Rjo mutation (0 available); any Lfng mutation (32 available)
Tg(Lfng*-LFNG)2Dihz mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Regional and dose-dependent rescue of the Lfng phenotype by transgenic expression in the stripe domain

mortality/aging

decreased survivor rate ( J:155378 )

• relative viability compared to wild-type controls is 9%

skeleton

abnormal axial skeleton morphology ( J:155378 )

• severely disorganized and truncated axial skeleton with irregular and fused vertebrae and vertebral bodies that rarely align with the midline

abnormal vertebral column morphology ( J:155378 )

abnormal thoracic vertebrae morphology ( J:155378 )

• slight restoration of thoracic vertebrae morphology compared to null mice not carrying the transgene

abnormal cervical vertebrae morphology ( J:155378 )

• slight restoration of cervical vertebrae morphology compared to null mice not carrying the transgene

abnormal lumbar vertebrae morphology ( J:155378 )

• slight restoration of lumbar vertebrae morphology compared to null mice not carrying the transgene

short vertebral column ( J:155378 )

• truncated axial skeleton

limbs/digits/tail

short tail ( J:155378 )

• tails are longer than in null mice not carrying the transgene but still shorter than in wild-type controls

Allelic Composition	Lfng^tm1Rjo/Lfng^tm1Rjo Tg(Lfng*-LFNG)1Dihz/0
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lfng^tm1Rjo mutation (0 available); any Lfng mutation (32 available)
Tg(Lfng*-LFNG)1Dihz mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Regional and dose-dependent rescue of the Lfng phenotype by transgenic expression in the stripe domain

mortality/aging

decreased survivor rate ( J:155378 )

• survival is improved compared to null mice not carrying the transgene but still less than that of wild-type controls

• relative viability compared to wild-type controls is 24%

skeleton

abnormal axial skeleton morphology ( J:155378 )

• severely disorganized and truncated axial skeleton with irregular and fused vertebrae and vertebral bodies that rarely align with the midline

abnormal vertebral column morphology ( J:155378 )

abnormal thoracic vertebrae morphology ( J:155378 )

• slight restoration of thoracic vertebrae morphology compared to null mice not carrying the transgene

abnormal cervical vertebrae morphology ( J:155378 )

• slight restoration of cervical vertebrae morphology compared to null mice not carrying the transgene

abnormal lumbar vertebrae morphology ( J:155378 )

• slight restoration of lumbar vertebrae morphology compared to null mice not carrying the transgene

short vertebral column ( J:155378 )

• truncated axial skeleton

limbs/digits/tail

short tail ( J:155378 )

• tails are longer than in null mice not carrying the transgene but still shorter than in wild-type controls

Allelic Composition	Lfng^tm1Rjo/Lfng^tm1Rjo Tg(Lfng-LFNG)1Dihz/Tg(Lfng-LFNG)1Dihz
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lfng^tm1Rjo mutation (0 available); any Lfng mutation (32 available)
Tg(Lfng*-LFNG)1Dihz mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Regional and dose-dependent rescue of the Lfng phenotype by transgenic expression in the stripe domain

mortality/aging

decreased survivor rate ( J:155378 )

• survival is improved compared to null mice not carrying the transgene but still less than that of wild-type controls

• relative viability compared to wild-type controls is 20%

skeleton

abnormal axial skeleton morphology ( J:155378 )

• severely disorganized and truncated axial skeleton with irregular and fused vertebrae and vertebral bodies that rarely align with the midline

abnormal vertebral column morphology ( J:155378 )

• rescue of abnormalities is confined to segmentation of the tail area

short vertebral column ( J:155378 )

• truncated axial skeleton

limbs/digits/tail

kinked tail ( J:155378 )

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