About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cdkn2btm1Bbd
targeted mutation 1, Mariano Barbacid
MGI:1933760
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cdkn2btm1Bbd/Cdkn2btm1Bbd involves: 129S1/Sv * C57BL/6 MGI:2175772
cn2
 		Cdkn2btm1Bbd/Cdkn2btm1Bbd
Pbx1tm1Koss/Pbx1tm1Koss
Nkx2-5tm2(cre)Rph/Nkx2-5+ 		involves: 129P2/OlaHsd * 129S1/Sv MGI:5426986
cx3
 		Cdkn2btm1Bbd/Cdkn2btm1Bbd
Cdkn2ctm1Bbd/Cdkn2ctm1Bbd 		involves: 129S1/Sv * C57BL/6 MGI:2662500


Genotype
MGI:2175772
hm1
Allelic
Composition		 Cdkn2btm1Bbd/Cdkn2btm1Bbd
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2btm1Bbd mutation (1 available); any Cdkn2b mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:63299 )
• some mice die between 9 and 18 months of age; these mice have no evidence of tumors but have severe extramedullary hematopoiesis

immune system
abnormal lymphocyte morphology ( J:63299 )
• lymphocytes exhibit increased proliferation upon mitogenic stimulation
increased mature B cell number ( J:63299 )
• increase in levels of mature B cells in spleen and lymph nodes
abnormal spleen marginal zone morphology ( J:63299 )
• enlarged marginal zones
abnormal lymph node secondary follicle morphology ( J:63299 )
• reactive lymph nodes characterized by prominent secondary follicles
abnormal lymph node germinal center morphology ( J:63299 )
• enlarged germinal centers
lymphoid hyperplasia ( J:63299 )
• mutants exhibit lymphoproliferative disorders

neoplasm
increased tumor incidence ( J:63299 )
• 8.2% incidence of tumors
• however, mutants do not show increased incidence of chemically-induced tumors
increased adenocarcinoma incidence ( J:63299 )
• adenocarcinomas of the lung and pancreas
increased sarcoma incidence ( J:63299 )
• 73% of tumors are of connective tissue origin, including angiosarcomas and skin fibrosarcoma

hematopoietic system
extramedullary hematopoiesis ( J:63299 )
• in the spleen
abnormal lymphocyte morphology ( J:63299 )
• lymphocytes exhibit increased proliferation upon mitogenic stimulation
increased mature B cell number ( J:63299 )
• increase in levels of mature B cells in spleen and lymph nodes
abnormal spleen marginal zone morphology ( J:63299 )
• enlarged marginal zones

cellular
abnormal cell physiology ( J:63299 )
• MEFs are susceptible to ras oncogenic transformation
increased fibroblast proliferation ( J:63299 )
• MEFs exhibit a higher proliferation rate and plating efficiency than wild-type MEFs
• serum starved MEFs re-enter the cell cycle more efficiently than wild-type MEFs

growth/size/body
spleen hyperplasia ( J:63299 )




Genotype
MGI:5426986
cn2
Allelic
Composition		 Cdkn2btm1Bbd/Cdkn2btm1Bbd
Pbx1tm1Koss/Pbx1tm1Koss
Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2btm1Bbd mutation (1 available); any Cdkn2b mutation (7 available)
Nkx2-5tm2(cre)Rph mutation (1 available); any Nkx2-5 mutation (21 available)
Pbx1tm1Koss mutation (0 available); any Pbx1 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal spleen morphology ( J:184521 )
• partial rescue of spleen expansion compared to mutant mice wild-type for Cdkn2b and spleens form a single compact anlage
abnormal spleen mesenchyme morphology ( J:184521 )
• significant rescue of mesenchymal proliferation compared to mutant mice wild-type for Cdkn2b

immune system
abnormal spleen morphology ( J:184521 )
• partial rescue of spleen expansion compared to mutant mice wild-type for Cdkn2b and spleens form a single compact anlage
abnormal spleen mesenchyme morphology ( J:184521 )
• significant rescue of mesenchymal proliferation compared to mutant mice wild-type for Cdkn2b




Genotype
MGI:2662500
cx3
Allelic
Composition		 Cdkn2btm1Bbd/Cdkn2btm1Bbd
Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2btm1Bbd mutation (1 available); any Cdkn2b mutation (7 available)
Cdkn2ctm1Bbd mutation (1 available); any Cdkn2c mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased testis tumor incidence ( J:63299 )
• testicular (Leydig cell) tumors
increased sarcoma incidence ( J:63299 )
• angiosarcomas appear in aged mice

endocrine/exocrine glands
abnormal mammary gland morphology ( J:63299 )
• cysts in mammary glands
abnormal testis morphology ( J:63299 )
• cysts in the testis
dilated rete testis ( J:63299 )
• seen in 37.5% of males
seminiferous tubule degeneration ( J:63299 )
• 37.5% of males show atrophy of the seminiferous tubes
enlarged testis ( J:63299 )
• 37.5% of males show enlarged testes with severe dilatation of the tubules of the rete testis with atrophy of seminiferous tubes, similar to human testicular dysplasia
increased testis tumor incidence ( J:63299 )
• testicular (Leydig cell) tumors

hematopoietic system
abnormal Langerhans cell morphology ( J:63299 )
• Langerhans islet hyperplasia
abnormal lymphocyte morphology ( J:63299 )
• lymphocytes show increased proliferation upon mitogenic stimulation

immune system
abnormal Langerhans cell morphology ( J:63299 )
• Langerhans islet hyperplasia
abnormal lymphocyte morphology ( J:63299 )
• lymphocytes show increased proliferation upon mitogenic stimulation
lymphoid hyperplasia ( J:63299 )
• 55% of mutants develop lymphoproliferative disorders to a similar extent as single Cdkn2b homozygotes

renal/urinary system

reproductive system
abnormal testis morphology ( J:63299 )
• cysts in the testis
dilated rete testis ( J:63299 )
• seen in 37.5% of males
seminiferous tubule degeneration ( J:63299 )
• 37.5% of males show atrophy of the seminiferous tubes
enlarged testis ( J:63299 )
• 37.5% of males show enlarged testes with severe dilatation of the tubules of the rete testis with atrophy of seminiferous tubes, similar to human testicular dysplasia
increased testis tumor incidence ( J:63299 )
• testicular (Leydig cell) tumors

cellular
abnormal cell physiology ( J:63299 )
• MEFs are susceptible to oncogenic ras transformation
increased fibroblast proliferation ( J:63299 )
• MEFs exhibit a higher proliferation rate and plating efficiency than wild-type MEFs, similar to single Cdkn2b homozygotes

integument
abnormal mammary gland morphology ( J:63299 )
• cysts in mammary glands

nervous system

growth/size/body
pancreas cyst ( J:63299 )
kidney cyst ( J:63299 )
enlarged spleen ( J:63299 )




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory