All Phenotypes Lef1<tm2Rug> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lef1^tm2Rug
targeted mutation 2, Rudolf Grosschedl
MGI:1933764

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lef1^tm2Rug/Lef1^tm2Rug	involves: 129S2/SvPas	MGI:2175100

Allelic Composition	Lef1^tm2Rug/Lef1^tm2Rug
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lef1^tm2Rug mutation (0 available); any Lef1 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal brain morphology ( J:59284 )

• brains have cystic defects in the external capsule

abnormal hippocampus development ( J:59284 )

• cell proliferation analysis shows a 30% reduction in the number of mitotically active cells in the region of the hippocampal primordium closer to the fimbria at E11.5

absent dentate gyrus ( J:59284 )

absent hippocampus ( J:59284 )

• entire hippocampus is missing at E16.5 due to defects in patterning and proliferation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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