All Phenotypes Ntf3<tm1Lfr> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ntf3^tm1Lfr/Ntf3^tm1Lfr	involves: 129S2/SvPas	MGI:2175178
hm2	Ntf3^tm1Lfr/Ntf3^tm1Lfr	involves: 129S2/SvPas * C57BL/6J	MGI:3044434
cx3	Etv1^tm1Tmj/Etv1^tm1Tmj Ntf3^tm1Lfr/Ntf3^tm1Lfr	involves: 129S1/Sv * 129S2/SvPas	MGI:3621022
cx4	Etv1^tm2Tmj/Etv1^tm2Tmj Ntf3^tm1Lfr/Ntf3^tm1Lfr	involves: 129S1/Sv * 129S2/SvPas	MGI:3621020

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:18984 )

• most die within 24 hours with a few (3 of 300 total) surviving for 7 - 15 days

nervous system

abnormal muscle spindle morphology ( J:132854 )

• fail to form spindles

absent muscle spindles ( J:18984 )

small superior cervical ganglion ( J:18984 )

• at P0, about a 50% decrease in cell number is detected without any increase in pyknotic neurons

small mesencephalic trigeminal nucleus ( J:18984 )

• loss of 56% of sensory neurons

abnormal sensory neuron innervation pattern ( J:18984 )

• group Ia afferents appear to be absent

decreased motor neuron number ( J:132854 )

• small diameter fusimotor axons are absent in the ventral roots of lumbar nerves

• elevated apoptosis of motor neurons between 13.5 and E15.5

abnormal cranial ganglia morphology ( J:18984 )

• loss of 30% of sensory neurons from the petrosal-nodose ganglia

cochlear ganglion hypoplasia ( J:18984 )

• loss of 85% of sensory neurons

small geniculate ganglion ( J:18984 )

• loss of 25% of sensory neurons

small trigeminal ganglion ( J:18984 )

• loss of 61% of sensory neurons

small L5 dorsal root ganglion ( J:18984 )

• loss of 78% of sensory neurons from the L5 ganglion

small dorsal root ganglion ( J:18984 )

• loss of 60 - 80% of neurons

• loss of 62% of sensory neurons from the C1 ganglion

behavior/neurological

abnormal food intake ( J:18984 )

• no evidence of food intake

athetotic walking movements ( J:18984 )

• seen in rare survivors

abnormal limb posture ( J:18984 )

• abnormal limb posture

decreased locomotor activity ( J:18984 )

muscle

abnormal muscle spindle morphology ( J:132854 )

• fail to form spindles

absent muscle spindles ( J:18984 )

Allelic Composition	Ntf3^tm1Lfr/Ntf3^tm1Lfr
Genetic Background	involves: 129S2/SvPas * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntf3^tm1Lfr mutation (1 available); any Ntf3 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal sensory neuron innervation pattern ( J:90280 )

• innervation of the somatosensory prominences is virtually absent

Allelic Composition	Etv1^tm1Tmj/Etv1^tm1Tmj Ntf3^tm1Lfr/Ntf3^tm1Lfr
Genetic Background	involves: 129S1/Sv * 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv1^tm1Tmj mutation (0 available); any Etv1 mutation (44 available)
Ntf3^tm1Lfr mutation (1 available); any Ntf3 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

absent golgi tendon organ ( J:75311 )

• absent from proximal and distal muscles in newborn double homozygotes

absent muscle spindles ( J:75311 )

• spindles are absent from proximal and distal muscles in newborn double homozygotes

muscle

absent golgi tendon organ ( J:75311 )

• absent from proximal and distal muscles in newborn double homozygotes

absent muscle spindles ( J:75311 )

• spindles are absent from proximal and distal muscles in newborn double homozygotes

Allelic Composition	Etv1^tm2Tmj/Etv1^tm2Tmj Ntf3^tm1Lfr/Ntf3^tm1Lfr
Genetic Background	involves: 129S1/Sv * 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv1^tm2Tmj mutation (0 available); any Etv1 mutation (44 available)
Ntf3^tm1Lfr mutation (1 available); any Ntf3 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

absent golgi tendon organ ( J:75311 )

• absent from proximal and distal muscles in newborn double homozygotes

absent muscle spindles ( J:75311 )

• spindles are absent from proximal and distal muscles in newborn double homozygotes

muscle

absent golgi tendon organ ( J:75311 )

• absent from proximal and distal muscles in newborn double homozygotes

absent muscle spindles ( J:75311 )

• spindles are absent from proximal and distal muscles in newborn double homozygotes

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