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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ntf5tm1Par
targeted mutation 1, Luis F Parada
MGI:1933845
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ntf5tm1Par/Ntf5tm1Par involves: 129S1/Sv MGI:3613020
hm2
 		Ntf5tm1Par/Ntf5tm1Par involves: 129S1/Sv * C57BL/6 MGI:2175183
cx3
 		Bdnftm1Par/Bdnftm1Par
Ntf5tm1Par/Ntf5tm1Par 		involves: 129S1/Sv * C57BL/6 MGI:3613013
cx4
 		Ntf3tm1Par/Ntf3tm1Par
Ntf5tm1Par/Ntf5tm1Par 		involves: 129S1/Sv * C57BL/6 MGI:3613014
cx5
 		Ntf5tm1Par/Ntf5tm1Par
Ntrk1tm1Par/Ntrk1tm1Par 		involves: 129S1/Sv * C57BL/6 MGI:3613015


Genotype
MGI:3613020
hm1
Allelic
Composition		 Ntf5tm1Par/Ntf5tm1Par
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntf5tm1Par mutation (0 available); any Ntf5 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:103935 )
N
• no defects in barrel cortex development




Genotype
MGI:2175183
hm2
Allelic
Composition		 Ntf5tm1Par/Ntf5tm1Par
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntf5tm1Par mutation (0 available); any Ntf5 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
impaired coordination ( J:60927 )
• ability to balance on a rotarod is reduced

nervous system
abnormal neuron differentiation ( J:60927 )
• reduction in number of differentiated dorsal root ganglion neurons at E13, indicating delayed neuronal differentiation
abnormal innervation pattern to muscle ( J:60927 )
• increase in proprioceptive muscle afferents as indicated by a 19% and 18% increase in the number of myelinated axons innervating the tibial nerve and the common peroneal nerve, respectively
abnormal sensory neuron innervation pattern ( J:60927 )
• altered sensory afferents as indicated by a 16% reduction in the number of myelinated axons innervating the saphenous nerve
abnormal dorsal root ganglion morphology ( J:60927 )
• 12% increase in neuron numbers in dorsal root ganglia at P0, but no differences at E13
• dorsal root ganglion neuronal cultures exhibit reduced numbers of Bdnf and Ntf5-responsive neurons and increased numbers of Ntf3-dependent neurons

cellular
abnormal neuron differentiation ( J:60927 )
• reduction in number of differentiated dorsal root ganglion neurons at E13, indicating delayed neuronal differentiation




Genotype
MGI:3613013
cx3
Allelic
Composition		 Bdnftm1Par/Bdnftm1Par
Ntf5tm1Par/Ntf5tm1Par
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnftm1Par mutation (0 available); any Bdnf mutation (42 available)
Ntf5tm1Par mutation (0 available); any Ntf5 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron differentiation ( J:60927 )
• reduction in number of differentiated dorsal root ganglion neurons at E13, indicating delayed neuronal differentiation, however numbers of sensory neurons are normal
abnormal dorsal root ganglion morphology ( J:60927 )
• dorsal root ganglion neuronal cultures exhibit reduced numbers of Bdnf and Ntf5-responsive neurons and increased numbers of Ntf3-dependent neurons

cellular
abnormal neuron differentiation ( J:60927 )
• reduction in number of differentiated dorsal root ganglion neurons at E13, indicating delayed neuronal differentiation, however numbers of sensory neurons are normal




Genotype
MGI:3613014
cx4
Allelic
Composition		 Ntf3tm1Par/Ntf3tm1Par
Ntf5tm1Par/Ntf5tm1Par
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntf3tm1Par mutation (0 available); any Ntf3 mutation (24 available)
Ntf5tm1Par mutation (0 available); any Ntf5 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
small trigeminal ganglion ( J:60927 )
• 74% reduction of trigeminal ganglion neurons at P0
small dorsal root ganglion ( J:60927 )
• 46% and 84% reduction of dorsal root ganglion neurons at E13 and P0, respectively




Genotype
MGI:3613015
cx5
Allelic
Composition		 Ntf5tm1Par/Ntf5tm1Par
Ntrk1tm1Par/Ntrk1tm1Par
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntf5tm1Par mutation (0 available); any Ntf5 mutation (12 available)
Ntrk1tm1Par mutation (0 available); any Ntrk1 mutation (62 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
small dorsal root ganglion ( J:60927 )
• 82% reduction of dorsal root ganglion neurons at P0




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory