All Phenotypes Cd14<tm1Frm> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd14^tm1Frm/Cd14^tm1Frm	B6.129S4-Cd14^tm1Frm	MGI:4412005
hm2	Cd14^tm1Frm/Cd14^tm1Frm	involves: 129S4/SvJae	MGI:3583158
hm3	Cd14^tm1Frm/Cd14^tm1Frm	involves: 129S4/SvJae * C57BL/6J	MGI:3583156
ht4	Cd14^tm1Frm/Cd14⁺	involves: 129S4/SvJae * C57BL/6J	MGI:3583157

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

pulmonary edema ( J:96680 )

• less protein leakage into bronchoalveolar lavage fluid after lipopolysaccharide inhalation

immune system

abnormal cytokine level ( J:96680 )

• keratinocyte derived cytokine levels in lungs are unaffected by low doses of lipopolysaccharide

• macrophage inflammatory protein-2 levels in lungs are unaffected by low doses of lipopolysaccharide

abnormal interleukin level ( J:96680 )

• Il-6 levels in lungs are unaffected by low doses of lipopolysaccharide

abnormal tumor necrosis factor level ( J:96680 )

• TNF alpha levels in lungs are unaffected by low doses of lipopolysaccharide

skeleton

increased bone mineral content ( J:118467 )

• greater mineral content

increased bone mineral density ( J:118467 )

increased bone mass ( J:118467 )

• increased bone area of the tibia

decreased susceptibility to bone fracture ( J:118467 )

• bones resistant to fracture

homeostasis/metabolism

pulmonary edema ( J:96680 )

• less protein leakage into bronchoalveolar lavage fluid after lipopolysaccharide inhalation

abnormal cytokine level ( J:96680 )

• keratinocyte derived cytokine levels in lungs are unaffected by low doses of lipopolysaccharide

• macrophage inflammatory protein-2 levels in lungs are unaffected by low doses of lipopolysaccharide

abnormal interleukin level ( J:96680 )

• Il-6 levels in lungs are unaffected by low doses of lipopolysaccharide

abnormal tumor necrosis factor level ( J:96680 )

• TNF alpha levels in lungs are unaffected by low doses of lipopolysaccharide

adipose tissue

decreased total body fat amount ( J:118467 )

growth/size/body

increased lean body mass ( J:118467 )

Allelic Composition	Cd14^tm1Frm/Cd14^tm1Frm
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd14^tm1Frm mutation (2 available); any Cd14 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal interferon secretion ( J:98908 )

• exhibited no type I interferon production in response to smooth LPS

decreased susceptibility to endotoxin shock ( J:98908 )

• exhibited no TNF production in response to smooth lipopolysaccharide (LPS), however response to lipid A from Salmonella Minnesota was normal

increased susceptibility to Riboviria infection ( J:98908 )

• macrophages exposed to vesicular stomatitis virus (VSV) could not contain the infection and were more susceptible to lysis than controls

Allelic Composition	Cd14^tm1Frm/Cd14^tm1Frm
Genetic Background	involves: 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd14^tm1Frm mutation (2 available); any Cd14 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal cytokine secretion ( J:65107 )

• macrophages exhibited loss of cytokine production in response to LPS and low levels of heat-killed E.coli (less than 1 E.coli per cell), however macrophages stimulated with high levels (10 E.coli per cell) of heat-killed E.coli, produced cytokine levels similar to wild-type while macrophages stimulated with lower levels (less than 10 E.coli per cell) produced reduced cytokine levels

decreased interleukin-6 secretion ( J:65107 )

• no IL-6 production by macrophages in response to LPS from E.coli K235

decreased tumor necrosis factor secretion ( J:65107 )

• no TNF-alpha production by macrophages in response to LPS from E.coli K235 or to low levels of heat-killed E.coli (less than 1 E.coli per cell)

Allelic Composition	Cd14^tm1Frm/Cd14⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd14^tm1Frm mutation (2 available); any Cd14 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal cytokine secretion ( J:65107 )

• macrophages exhibited a decrease in cytokine production in response to LPS

decreased interleukin-6 secretion ( J:65107 )

• decreased IL-6 production by macrophages in response to LPS

decreased tumor necrosis factor secretion ( J:65107 )

• decreased TNF production by macrophages in response to LPS

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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