Phenotypes associated with this allele

• Allele Symbol: Sell^tm1Hyn
• Allele Name: targeted mutation 1, Richard Hynes
• Allele ID: MGI:1934022
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Sele^tm1Hyn/Sele^tm1Hyn Sell^tm1Hyn/Sell^tm1Hyn Selp^tm1Hyn/Selp^tm1Hyn	involves: 129S2/SvPas * C57BL/6	MGI:3840206

Genotype
MGI:3840206

cx1

• Allelic Composition: Sele^tm1Hyn/Sele^tm1Hyn; Sell^tm1Hyn/Sell^tm1Hyn; Selp^tm1Hyn/Selp^tm1Hyn
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

impaired leukocyte tethering or rolling ( J:57973 )

• rolling leukocytes are virtually absent within the mesenteric venules of mice treated with TNF

• there is a three-quarter decrease in the number of adhering leukocytes within these mesenteric venules

• a population of leukocytes that are "fast rollers" is evident in these mice that are not observed in wild-type mice

increased leukocyte cell number ( J:57973 )

• there is a 2.5 fold increase in leukocyte numbers

increased eosinophil cell number ( J:57973 )

• eosinophil numbers are about 6-fold higher in the blood

increased neutrophil cell number ( J:57973 )

• neutrophils numbers are increased almost 10-fold

increased monocyte cell number ( J:57973 )

• monocyte number are increased about 5-fold

impaired eosinophil recruitment ( J:57973 )

• 2-fold fewer eosinophils are recruited to the peritoneum in response to ragweed allergen challenge

impaired neutrophil recruitment ( J:57973 )

• neutrophil influx in thioglycollate-induced peritonitis is inhibited at 2, 4, and 8 hours after injection compared to wild-type mice

• lower numbers of neutrophils are observed than those elicited from mice that are null homozygotes for just one gene

hematopoietic system

impaired leukocyte tethering or rolling ( J:57973 )

• rolling leukocytes are virtually absent within the mesenteric venules of mice treated with TNF

• there is a three-quarter decrease in the number of adhering leukocytes within these mesenteric venules

• a population of leukocytes that are "fast rollers" is evident in these mice that are not observed in wild-type mice

increased leukocyte cell number ( J:57973 )

• there is a 2.5 fold increase in leukocyte numbers

increased eosinophil cell number ( J:57973 )

• eosinophil numbers are about 6-fold higher in the blood

increased neutrophil cell number ( J:57973 )

• neutrophils numbers are increased almost 10-fold

increased monocyte cell number ( J:57973 )

• monocyte number are increased about 5-fold

impaired eosinophil recruitment ( J:57973 )

• 2-fold fewer eosinophils are recruited to the peritoneum in response to ragweed allergen challenge

impaired neutrophil recruitment ( J:57973 )

• neutrophil influx in thioglycollate-induced peritonitis is inhibited at 2, 4, and 8 hours after injection compared to wild-type mice

• lower numbers of neutrophils are observed than those elicited from mice that are null homozygotes for just one gene

cellular

impaired leukocyte tethering or rolling ( J:57973 )

• rolling leukocytes are virtually absent within the mesenteric venules of mice treated with TNF

• there is a three-quarter decrease in the number of adhering leukocytes within these mesenteric venules

• a population of leukocytes that are "fast rollers" is evident in these mice that are not observed in wild-type mice