All Phenotypes Trpv1<tm1Jul> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trpv1^tm1Jul/Trpv1^tm1Jul	B6.129X1-Trpv1^tm1Jul	MGI:4418196
hm2	Trpv1^tm1Jul/Trpv1^tm1Jul	B6.129X1-Trpv1^tm1Jul/J	MGI:4417977
hm3	Trpv1^tm1Jul/Trpv1^tm1Jul	involves: 129X1/SvJ	MGI:2655322
hm4	Trpv1^tm1Jul/Trpv1^tm1Jul	involves: 129X1/SvJ * C57BL/6	MGI:3834761
cn5	Gt(ROSA)26Sor^{tm1(Trpv1,ECFP)Mde}/Gt(ROSA)26Sor⁺ Trpv1^tm1Jul/Trpv1^tm1Jul Tg(Mrgpra3-GFP/cre)#Xzd/0	involves: 129P2/OlaHsd * 129X1/SvJ	MGI:5506549
cx6	Trpv1^tm1Jul/Trpv1^tm1Jul Pirt^tm2Xzd/Pirt⁺	involves: 129X1/SvJ	MGI:5697887

Allelic Composition	Trpv1^tm1Jul/Trpv1^tm1Jul
Genetic Background	B6.129X1-Trpv1^tm1Jul

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpv1^tm1Jul mutation (1 available); any Trpv1 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:117778 )

N	• mice exhibit normal general locomotion and pain threshold

abnormal behavior ( J:117778 )

• mice exhibit less freezing after stress sensitization compared with wild-type mice

impaired contextual conditioning behavior ( J:117778 )

• mice exhibit less conditioned freezing in response to a context compared with wild-type mice

impaired cued conditioning behavior ( J:117778 )

• mice exhibit less conditioned freezing in response to an auditory cue compared with wild-type mice

decreased anxiety-related response ( J:117778 )

• in a light-dark test, mice spend more time exploring the light compartment than wild-type mice

• in an elevated plus maze, mice spend more time in open arms and make more entries into open arms compared with wild-type mice

renal/urinary system

abnormal urine homeostasis ( J:154624 )

• DOCA-salt-treated mice exhibit a greater increase in urinary 8-isoprostane and albumin excretion compared with similarly treated wild-type mice

• however, DEXA treatment decreased urinary 8-isoprotane and albumin excretion

increased urine protein level ( J:154624 )

• DOCA-salt-treated mice exhibit a greater increase in urinary albumin excretion compared with similarly treated wild-type mice

• however, DEXA treatment decreased urinary albumin excretion

kidney inflammation ( J:154624 )

• DOCA-salt-treated mice exhibit a more monocyte/macrophage and CD3+ T cell infiltration than similarly treated wild-type mice

• however, DEXA treatment prevents kidney inflammation

glomerulosclerosis ( J:154624 )

• DOCA-salt-treated mice exhibit a greater glomerulosclerosis than similarly treated wild-type mice

• however, DEXA treatment reduces glomerulosclerosis

abnormal renal tubule morphology ( J:154624 )

• DOCA-salt-treated mice exhibit more severe renal tubular injury in the renal cortex and outer medulla than similarly treated wild-type mice

• however, DEXA treatment reduces renal tubule damage

nervous system

nervous system phenotype ( J:117778 )

N	• mice exhibit normal paired-pulse facilitation, auditory brainstem responses, and distortion-product otoacoustic emissions

reduced long-term potentiation ( J:117778 )

• following high frequency stimulation, long term potentiation is weaker than in similarly treated wild-type mice

homeostasis/metabolism

abnormal urine homeostasis ( J:154624 )

• DOCA-salt-treated mice exhibit a greater increase in urinary 8-isoprostane and albumin excretion compared with similarly treated wild-type mice

• however, DEXA treatment decreased urinary 8-isoprotane and albumin excretion

increased urine protein level ( J:154624 )

• DOCA-salt-treated mice exhibit a greater increase in urinary albumin excretion compared with similarly treated wild-type mice

• however, DEXA treatment decreased urinary albumin excretion

increased susceptibility to injury ( J:154624 )

• DOCA-salt-treated mice exhibit increased renal damage compared with similarly treated wild-type mice

• however, DEXA treatment ameliorates renal damage

immune system

abnormal chemokine secretion ( J:154624 )

• DOCA-salt-treated mice exhibit increased MCP-1 protein levels in the kidneys of compared with similarly treated wild-type mice

• however, DEXA treatment restores normal levels

increased interleukin-6 secretion ( J:154624 )

• DOCA-salt-treated mice exhibit increased IL6 protein levels in the kidneys of compared with similarly treated wild-type mice

• however, DEXA treatment restores normal levels

increased tumor necrosis factor secretion ( J:154624 )

• DOCA-salt-treated mice exhibit increased TNFalpha protein levels in the kidneys of compared with similarly treated wild-type mice

• however, DEXA treatment restores normal levels

kidney inflammation ( J:154624 )

• DOCA-salt-treated mice exhibit a more monocyte/macrophage and CD3+ T cell infiltration than similarly treated wild-type mice

• however, DEXA treatment prevents kidney inflammation

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal response of heart to induced stress ( J:116905 )

• after ischemia and during reperfusion, mice exhibit impaired recovery with lower left ventricular end diastolic pressure and higher left ventricle developed pressure and coronary flow compared with similarly treated wild-type mice

• however, treatment with calcitonin gene-related peptide or substance P improves postischemic recovery as in wild-type mice

increased blood osmolality ( J:105254 )

abnormal physiological response to xenobiotic ( J:96901 , J:105525 , J:128319 , J:132936 )

• mice treated with PAR2-AP alone or in combination with capsaicin fail to exhibit thermal hyperalgesia unlike similarly treated wild-type mice (J:96901)

• anandamide-treated mice fail to exhibit phase I (decreased mean arterial blood pressure, cardiac contractility, and heart rate) and exhibit a reduced phase II pressor response compared with similarly treated wild-type mice (J:105525)

• capsaicin-treatment mice fail to exhibit a anandamide-like phase I and II response as in similarly treated wild-type mice (J:105525)

• however, the prolonged hypotensive response to anandamide-treatment is normal (J:105525)

• following induction of colonic distention, mice fail to exhibit zymogen-induced behavioral hypersensitivity, as measured by visceral nociception, unlike similarly treated wild-type mice (J:128319)

• capsaicin-treated mice fail to exhibit synaptic depression unlike similarly treated wild-type mice (J:132936)

• 12-(S)-HPETE fails to depress synaptic transmission at excitatory synapses in interneurons unlike in wild-type mice (J:132936)

nervous system

abnormal neuronal precursor proliferation ( J:102006 )

• neuronal precursor cell proliferation in the dorsal ganglion and subventricular zone (SVZ) is increased compared to in wild-type mice

• SR141716A does not affected proliferation in the dorsal ganglion and decreases proliferation in the SVZ unlike in similarly treated wild-type mice

abnormal nervous system electrophysiology ( J:105254 )

• in response to hyperosmotic stimulation, supraoptic nucleus neurons fail to generate an increase in membrane conductance and depolarizing potentials unlike similarly treated wild-type cells

abnormal action potential ( J:109767 )

• impulse frequency of action potentials in colon sensory neurons at 45 degrees Celsius is lower than in similarly treated wild-type cells

• colon sensory neurons fail to exhibit a sustained-type current response to protons unlike similarly treated wild-type cells

• colon sensory neurons fail to exhibit a temperature sensitive response or 5-HT effect unlike similarly treated wild-type cells

impaired ability to fire action potentials ( J:109767 )

• temperatures below 50 degrees Celsius generate few action potentials in colon sensory neurons unlike in similarly treated wild-type cells

reduced long-term depression ( J:132936 )

decreased synaptic depression ( J:132936 )

• capsaicin-treated mice fail to exhibit synaptic depression unlike similarly treated wild-type mice

• 12-(S)-HPETE fails to depress synaptic transmission at excitatory synapses in interneurons unlike in wild-type mice

cardiovascular system

increased coronary flow rate ( J:116905 )

• after ischemia and during reperfusion

decreased left ventricle diastolic pressure ( J:116905 )

• after ischemia and during reperfusion

increased left ventricle developed pressure ( J:116905 )

• after ischemia and during reperfusion

abnormal response of heart to induced stress ( J:116905 )

• however, treatment with calcitonin gene-related peptide or substance P improves postischemic recovery as in wild-type mice

growth/size/body

increased body weight ( J:133914 )

• mice fed a high fat diet and treated with capsaicin fail to exhibit a decrease in body weight compared with similarly treated wild-type mice

behavior/neurological

behavior/neurological phenotype ( J:132700 , J:153529 )

N	• mice exhibit normal tactile hypersensitivity and allodynia following spinal nerve ligation (J:132700) • mice exhibit normal water consumption and ethanol-induced conditioned taste aversion (J:153529)

alcohol preference ( J:153529 )

• mice exhibit greater preference for ethanol than wild type mice in a two-bottle test

increased alcohol consumption ( J:153529 )

• mice consume more ethanol than wild-type mice in a two-bottle test

impaired behavioral response to alcohol ( J:153529 )

• duration of loss of righting reflex following ethanol consumption (at 3.2 g/kg and 3.4 g/kg but not 3.8 g/kg) is shorter than in similarly treated wild-type mice

• recovery from impaired coordination following ethanol consumption is faster than for similarly treated wild-type mice

• however, mice exhibit normal acute ethanol withdrawal severity

abnormal righting response ( J:153529 )

• duration of loss of righting reflex following ethanol consumption (at 3.2 g/kg and 3.4 g/kg but not 3.8 g/kg) is shorter than in similarly treated wild-type mice

impaired coordination ( J:153529 )

• recovery from impaired coordination following ethanol consumption is faster than for similarly treated wild-type mice

abnormal mechanical nociception ( J:128319 )

• following induction of colonic distention, mice fail to exhibit zymogen-induced behavioral hypersensitivity, as measured by visceral nociception, unlike similarly treated wild-type mice

increased thermal nociceptive threshold ( J:96901 )

• mice treated with PAR2-AP alone or in combination with capsaicin fail to exhibit thermal hyperalgesia unlike similarly treated wild-type mice

taste/olfaction

abnormal taste sensitivity ( J:145940 )

• at high concentrations, mice exhibit a less aversion to FeSO4 than wild-type mice

• mice exhibit less aversion to 10 mM CuSO4 than wild-type mice

• however, aversion to ZnSO4 is normal

integument

abnormal hair cycle ( J:110694 )

• mice exhibit delays in the onset of catagen and telogen compared with wild-type mice

• however, follicle cycling is normal once initiated

abnormal hair cycle catagen phase ( J:110694 )

• at P19, mice exhibit a retardation in catagen compared with wild-type mice

abnormal hair cycle telogen phase ( J:110694 )

• slightly retarded at P25

cellular

abnormal neuronal precursor proliferation ( J:102006 )

• neuronal precursor cell proliferation in the dorsal ganglion and subventricular zone (SVZ) is increased compared to in wild-type mice

• SR141716A does not affected proliferation in the dorsal ganglion and decreases proliferation in the SVZ unlike in similarly treated wild-type mice

Allelic Composition	Trpv1^tm1Jul/Trpv1^tm1Jul
Genetic Background	involves: 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpv1^tm1Jul mutation (1 available); any Trpv1 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased fluid intake ( J:112194 )

• following an injection of a hypertonic solution, mice drink water less than similarly treated wild-type mice

abnormal nociception after inflammation ( J:61534 )

• reduced thermal hypersensitvitiy following inflammation

hypoalgesia ( J:61534 , J:197482 )

• mutants show normal responses to noxious mechanical stimuli but exhibit no vanilloid-evoked pain behavior, are impaired in the detection of painful heat, and show little thermal hypersensitivity in the setting of inflammation (J:61534)

• cheek injection of capsaicin does not evoke pain behavior (forepaw facial wiping), in contrast to robust facial wiping observed in treated wild-type (J:197482)

increased chemical nociceptive threshold ( J:61534 )

• mutants exhibit no vanilloid (capsaicin and resiniferatoxin) evoked pain behavior: no behavioral response and less swelling with vanilloid injection into plantar skin of hind paw, no aversive response to drinking capsaicin supplemented water, and no reduction in temperature in response to capsaicin injection

increased thermal nociceptive threshold ( J:61534 , J:197482 )

• mutants exhibit reduced sensitivity to painful heat in behavioral tests, with longer mean withdrawal latencies in the tail immersion test at temperatures greater than 48 degrees Celcius and longer response latencies at temperatures greater than 50 degrees Celcius in the hot plate assay (J:61534)

• mutants treated with mustard oil show little or no change in hot plate latency (J:61534)

• mice show increased latencies (impaired nociceptive response) in tail-immersion and hot plate paradigms (J:197482)

nervous system

abnormal nervous system electrophysiology ( J:112194 )

• in response to osmotic stimulation, organum vasculosum lamina terminalis neurons fail to exhibit changes in membrane potential or conductance unlike similarly treated wild-type cells

impaired ability to fire action potentials ( J:112194 )

• in response to osmotic stimulation, organum vasculosum lamina terminalis neurons fail to exhibit an increase in action potential firing compared with similarly treated wild-type cells

abnormal neuron physiology ( J:329699 )

• significant attenuation of oxidated IP defensin 1 (IP-O) induced Ca2+ signaling in dorsal root ganglion (DRG) neurons

• reduction in the proportion of HIS-sensitive cells in DRG

abnormal sensory neuron physiology ( J:61534 )

• sensory neurons and primary afferent fibers show a reduction in proton (pH5) sensitivity in vitro (acid-evoked nociception)

• incidence of noxious heat-evoked currents of the moderate-threshold (greater than 43 degrees Celcius) class is reduced in cultured sensory neurons or sensory nerve fibers but high-threshold responses remain intact

• vanilloid compounds, capsaicin and resiniferatoxin, are completely inactive on neurons from mutants, showing no increases in calcium or inward currents

• mutants treated with mustard oil show little or no chmutants treated with mustard oil show no enhancement of thermally evoked responses in wide dynamic range neurons of the lumbar dorsal horn

adipose tissue

decreased subcutaneous adipose tissue amount ( J:137026 )

• when fed a high fat diet compared with similarly treated wild-type mice

decreased fat cell size ( J:137026 )

• when fed a high fat diet compared with similarly treated wild-type mice

decreased abdominal fat pad weight ( J:137026 )

• when fed a high fat diet compared with similarly treated wild-type mice

growth/size/body

decreased susceptibility to diet-induced obesity ( J:137026 )

• when fed a high fat diet compared with similarly treated wild-type mice

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:137026 )

• when fed a high fat diet compared with similarly treated wild-type mice

decreased susceptibility to induced hypothermia ( J:137026 )

• whether fed a standard or high fat diet, cold-treated mice do not exhibit the drop in body temperature observed in similarly treated wild-type mice

liver/biliary system

decreased susceptibility to diet-induced hepatic steatosis ( J:137026 )

• when fed a high fat diet, mice exhibit reduced hepatic fat content and reduced lipid droplets compared with similarly treated wild-type mice

integument

decreased subcutaneous adipose tissue amount ( J:137026 )

• when fed a high fat diet compared with similarly treated wild-type mice

decreased pruritus ( J:329699 )

• decreased IP-O induced scratch response

Allelic Composition	Trpv1^tm1Jul/Trpv1^tm1Jul
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpv1^tm1Jul mutation (1 available); any Trpv1 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:104828 )

N	• mice exhibit normal circadian core body temperature, response to warm or cold exposure, and ethanol-induced hypothermia

impaired febrile response ( J:104828 )

• the amplitude of the fever response to LPS-treatment is blunted compared to in similarly treated wild-type mice

increased incidence of tumors by chemical induction ( J:144978 )

• skin carcinogenesis is enhanced in mice treated with DMBA and TPA over a period of 21 weeks

• about 75% of mice developed skin tumors compared to under 25% for controls, with the tumors being larger and more numerous

renal/urinary system

abnormal urination ( J:78707 )

• increased frequency of non-voiding contractions

• the frequency of and strength voiding contractions were similar those of wild-type littermates

neoplasm

increased incidence of tumors by chemical induction ( J:144978 )

• skin carcinogenesis is enhanced in mice treated with DMBA and TPA over a period of 21 weeks

• about 75% of mice developed skin tumors compared to under 25% for controls, with the tumors being larger and more numerous

immune system

decreased susceptibility to endotoxin shock ( J:104828 )

• the amplitude of the fever response to LPS-treatment is blunted compared to in similarly treated wild-type mice

Allelic Composition	Gt(ROSA)26Sor^{tm1(Trpv1,ECFP)Mde}/Gt(ROSA)26Sor⁺ Trpv1^tm1Jul/Trpv1^tm1Jul Tg(Mrgpra3-GFP/cre)#Xzd/0
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(Trpv1,ECFP)Mde} mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Mrgpra3-GFP/cre)#Xzd mutation (0 available)
Trpv1^tm1Jul mutation (1 available); any Trpv1 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

hypoalgesia ( J:197482 )

• cheek injection of capsaicin does not evoke pain behavior (forepaw facial wiping), in contrast to robust facial wiping observed in treated wild-type

increased thermal nociceptive threshold ( J:197482 )

• mice have impaired nociceptive responses, showing increased latencies in tail-immersion and hot plate paradigms

integument

increased pruritus ( J:197482 )

• robust itch behavior is observed after cheek injection of capsaicin compared to little hindpaw scratching seen in treated wild-type

Allelic Composition	Trpv1^tm1Jul/Trpv1^tm1Jul Pirt^tm2Xzd/Pirt⁺
Genetic Background	involves: 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pirt^tm2Xzd mutation (0 available); any Pirt mutation (13 available)
Trpv1^tm1Jul mutation (1 available); any Trpv1 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron physiology ( J:213013 )

• complete absence of Ca+2 signals in sensory neurons after capsaicin stimulation

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