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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tacr1tm1Nge
targeted mutation 1, Norma P Gerard
MGI:1934027
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tacr1tm1Nge/Tacr1tm1Nge involves: 129S4/SvJae MGI:3619517
hm2
 		Tacr1tm1Nge/Tacr1tm1Nge involves: 129S4/SvJae * C57BL MGI:3665484


Genotype
MGI:3619517
hm1
Allelic
Composition		 Tacr1tm1Nge/Tacr1tm1Nge
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tacr1tm1Nge mutation (0 available); any Tacr1 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal humoral immune response ( J:35529 )
• after injection of chicken egg albumin in the tail and administration of antibodies to egg albumin intratracheally, the null mice exhibit almost complete protection from inflammatory response upon examination of lung tissue

nervous system
abnormal nervous system electrophysiology ( J:106546 )
• at stimulus frequencies of 0.2 and 1 Hz, C-fiber responses progressively increase in wild-type, but in mutants there are significantly less frequency dependent increases




Genotype
MGI:3665484
hm2
Allelic
Composition		 Tacr1tm1Nge/Tacr1tm1Nge
Genetic
Background		 involves: 129S4/SvJae * C57BL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tacr1tm1Nge mutation (0 available); any Tacr1 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased vascular permeability ( J:84660 )
• do not display increased vascular permeability in the dura mater in response to acute restrain stress as is seen in wild-type controls

immune system
abnormal mast cell physiology ( J:84660 )
• acute restrain stress does not result in increased dura mast cell activation as in wild-type

hematopoietic system
abnormal mast cell physiology ( J:84660 )
• acute restrain stress does not result in increased dura mast cell activation as in wild-type




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory