All Phenotypes Soat1<tm1Ishi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Soat1^tm1Ishi
targeted mutation 1, Shun Ishibashi
MGI:1934032

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Soat1^tm1Ishi/Soat1^tm1Ishi	involves: 129S7/SvEvBrd * C57BL/6	MGI:2174742
cx2	Soat1^tm1Ishi/Soat1^tm1Ishi Apoe^tm1Unc/Apoe^tm1Unc	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6	MGI:3582202
cx3	Soat1^tm1Ishi/Soat1^tm1Ishi Ldlr^tm1Her/Ldlr^tm1Her	involves: 129S7/SvEvBrd * C57BL/6	MGI:3582203

Allelic Composition	Soat1^tm1Ishi/Soat1^tm1Ishi
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Soat1^tm1Ishi mutation (0 available); any Soat1 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Narrow eye fissures and atrophic meibomian glands in Soat1^tm1Ishi/Soat1^tm1Ishi mice

vision/eye

Meibomian gland atrophy ( J:63468 )

narrow eye opening ( J:63468 )

dry eyes ( J:63468 )

homeostasis/metabolism

abnormal lipid homeostasis ( J:63468 )

• adrenocortical lipid depletion

endocrine/exocrine glands

Meibomian gland atrophy ( J:63468 )

integument

Meibomian gland atrophy ( J:63468 )

Allelic Composition	Soat1^tm1Ishi/Soat1^tm1Ishi Apoe^tm1Unc/Apoe^tm1Unc
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Unc mutation (33 available); any Apoe mutation (158 available)
Soat1^tm1Ishi mutation (0 available); any Soat1 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Cutaneous xanthomatosis and alopecia in Soat1^tm1Ishi/Soat1^tm1Ishi Apoe^tm1Unc/Apoe^tm1Unc and Soat1^tm1Ishi/Soat1^tm1Ishi Ldlr^tm1Her/Ldlr^tm1Her mice

vision/eye

Meibomian gland atrophy ( J:63468 )

dry eyes ( J:63468 )

homeostasis/metabolism

abnormal lipid homeostasis ( J:63468 )

• adrenocortical lipid depletion

increased circulating cholesterol level ( J:63468 )

• increased serum cholesterol levels

• hypercholesterolemia when fed a high fat diet

xanthoma ( J:63468 )

• cutaneous xanthomatosis

integument

alopecia ( J:63468 )

decreased hair follicle number ( J:63468 )

abnormal dermal layer morphology ( J:63468 )

• necrotic dermis

Meibomian gland atrophy ( J:63468 )

mixed cellular infiltration to dermis ( J:63468 )

• macrophage infiltration of dermis

thick dermal layer ( J:63468 )

skin lesions ( J:63468 )

abnormal skin condition ( J:63468 )

• rough skin

thick skin ( J:63468 )

endocrine/exocrine glands

Meibomian gland atrophy ( J:63468 )

Allelic Composition	Soat1^tm1Ishi/Soat1^tm1Ishi Ldlr^tm1Her/Ldlr^tm1Her
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlr^tm1Her mutation (19 available); any Ldlr mutation (81 available)
Soat1^tm1Ishi mutation (0 available); any Soat1 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Cutaneous xanthomatosis and alopecia in Soat1^tm1Ishi/Soat1^tm1Ishi Apoe^tm1Unc/Apoe^tm1Unc and Soat1^tm1Ishi/Soat1^tm1Ishi Ldlr^tm1Her/Ldlr^tm1Her mice

vision/eye

Meibomian gland atrophy ( J:63468 )

dry eyes ( J:63468 )

homeostasis/metabolism

abnormal lipid homeostasis ( J:63468 )

• adrenocortical lipid depletion

increased circulating cholesterol level ( J:63468 )

• increased serum cholesterol levels

• hypercholesterolemia

xanthoma ( J:63468 )

• cutaneous xanthomatosis

endocrine/exocrine glands

Meibomian gland atrophy ( J:63468 )

integument

Meibomian gland atrophy ( J:63468 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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