Analysis Tools
embryo
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• exposed neuroepithelium at E10.5
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• floor plate is enlarged at E10.5
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• E15.5 mutants show a malformed neural tube that is persistently open from midbrain to tail
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nervous system
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• exposed neuroepithelium at E10.5
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• floor plate is enlarged at E10.5
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• E15.5 mutants show a malformed neural tube that is persistently open from midbrain to tail
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• malformed forebrain at E10.5
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growth/size/body
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• palatal shelves are of almost normal length at E12.5 but shorter than wild-type shelves at E14.5
• however, no cleft palate is detected and palatal rugae formation is not affected at E12.5 or E14.5, as revealed by normal Shh expression at these stages
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short snout
(
J:223183
)
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• at E16.5, the snout is shorter than in wild-type controls
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hearing/vestibular/ear
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• malformation of both otic vesicles at E10.5
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craniofacial
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• palatal shelves are of almost normal length at E12.5 but shorter than wild-type shelves at E14.5
• however, no cleft palate is detected and palatal rugae formation is not affected at E12.5 or E14.5, as revealed by normal Shh expression at these stages
|
short snout
(
J:223183
)
|
• at E16.5, the snout is shorter than in wild-type controls
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digestive/alimentary system
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• palatal shelves are of almost normal length at E12.5 but shorter than wild-type shelves at E14.5
• however, no cleft palate is detected and palatal rugae formation is not affected at E12.5 or E14.5, as revealed by normal Shh expression at these stages
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