Phenotypes associated with this allele

• Allele Symbol: Hoxb8^tm1Jdes
• Allele Name: targeted mutation 1, Jacqueline Deschamps
• Allele ID: MGI:1934177
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxb8^tm1Jdes/Hoxb8^tm1Jdes	involves: 129P2/OlaHsd * FVB	MGI:3847691

Genotype
MGI:3847691

hm1

• Allelic Composition: Hoxb8^tm1Jdes/Hoxb8^tm1Jdes
• Genetic Background: involves: 129P2/OlaHsd * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal rib morphology ( J:58621 )

• at E18.5, mice exhibit severe reduction of the T1 ribs unlike wild-type mice

abnormal vertebral column morphology ( J:58621 )

• in all mice at E18.5

behavior/neurological

limb grasping ( J:58621 )

abnormal gait ( J:58621 )

• mice raise hindlimbs higher than wild-type mice do when walking

nervous system

abnormal dorsal root ganglion morphology ( J:58621 )

• 1 of 2 and 2 of 2 mice exhibit abnormal rostral and caudal moieties, respectively, of the left side of the C2 spinal ganglion

• all mice exhibit abnormal rostral and caudal moieties of the right side of the C2 spinal ganglion

growth/size/body

postnatal growth retardation ( J:58621 )

• mice exhibit slowed postnatal growth compared to wild-type mice

• however, mice reach normal weight by weaning

integument

skin lesions ( J:58621 )

• in one third of mice