All Phenotypes Gab1<tm1Wbm> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gab1^tm1Wbm/Gab1^tm1Wbm	involves: 129P2/OlaHsd	MGI:3617780
hm2	Gab1^tm1Wbm/Gab1^tm1Wbm	involves: 129P2/OlaHsd * C57BL/6	MGI:2177557
hm3	Gab1^tm1Wbm/Gab1^tm1Wbm	involves: 129P2/OlaHsd * C57BL/6 * CD-1	MGI:3759964
ht4	Gab1^tm1Wbm/Gab1⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:3617775
cx5	Cxcr4^tm1Qma/Cxcr4^tm1Qma Gab1^tm1Wbm/Gab1^tm1Wbm	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6	MGI:3617774
cx6	Gab1^tm1Wbm/Gab1^tm1Wbm Met^tm1Cbm/Met^tm1Cbm	involves: 129P2/OlaHsd * C57BL/6	MGI:3617777
cx7	Cd44^tm1Mak/Cd44^tm1Mak Gab1^tm1Wbm/Gab1⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:4946522

Allelic Composition	Gab1^tm1Wbm/Gab1^tm1Wbm
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gab1^tm1Wbm mutation (0 available); any Gab1 mutation (78 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal muscle precursor cell migration ( J:100909 )

• at E10.75 fewer hypaxial muscle progenitor cells reach the floor of the first branchial arch

abnormal intrinsic tongue muscle morphology ( J:100909 )

• the intrinsic tongue muscle is smaller but present

hypaxial muscle hypoplasia ( J:100909 )

• limb muscle size is reduced and in the proximal portion of the lower forelimb, particular extensor muscles of dorsal limb are reduced in size

digestive/alimentary system

abnormal intrinsic tongue muscle morphology ( J:100909 )

• the intrinsic tongue muscle is smaller but present

craniofacial

abnormal intrinsic tongue muscle morphology ( J:100909 )

• the intrinsic tongue muscle is smaller but present

cellular

abnormal muscle precursor cell migration ( J:100909 )

• at E10.75 fewer hypaxial muscle progenitor cells reach the floor of the first branchial arch

growth/size/body

abnormal intrinsic tongue muscle morphology ( J:100909 )

• the intrinsic tongue muscle is smaller but present

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:68751 )

• from E13.5 to E18.5 the proportion of viable homozygous mice decreases with none born alive

embryo

abnormal placenta vasculature ( J:68751 )

• at E13.5, the extracellular matrix around fetal blood vessels is fragmented and fetal blood cells are occasionally seen infiltrating the trophoblast layer

decreased trophoblast giant cell number ( J:68751 )

• at E13.5

abnormal placenta labyrinth morphology ( J:68751 )

• at E13.5, the labyrinth layer is disorganized, reduced in thickness and contains less blood; however the spongiotrophoblast layer is similar to wild-type

thin placenta labyrinth ( J:68751 )

• at E13.5

disorganized placental labyrinth ( J:68751 )

• at E13.5

muscle

abnormal muscle precursor cell migration ( J:68751 )

• at E10.25, fewer progenitor cells have delaminated from the occipitally located somites and the precursor stream headed for the floor of the branchial arches contains fewer cells and does not extend as far distally as in wild-type

• at E10.25, fewer precursor cells are found in the forelimb bud with the dorsal forelimb most strongly affected

abnormal diaphragm development ( J:68751 )

• at E13.5 the diaphragm muscle is reduced in size; however the internal tongue muscle appears normal

hypaxial muscle hypoplasia ( J:68751 )

• at E14.5 in the proximal lower forelimb the extensor muscle groups are either absent or very small while the flexor groups are present and in the distal lower forelimb only traces of muscle cells are found

• at E14.5 in the hindlimb some muscle groups are present but reduced in size and distal muscles are more severely affected

liver/biliary system

decreased liver weight ( J:68751 )

• at E14.5, the liver to body weight ratio is significantly reduced (0.05 versus 0.088 in wild-type)

growth/size/body

fetal growth retardation ( J:68751 )

• from E13.5 to E18.5 surviving embryos show a gradual delay in growth and development

integument

abnormal hair follicle development ( J:68751 )

• at E14.5 follicle development appears normal but by E17.5 hair follicle outgrowth is retarded and the number of follicles is reduced possibly reflect the reduction in total body size

thin epidermis ( J:68751 )

• at E17.5

abnormal keratinocyte physiology ( J:68751 )

• at E17.5, keratinization is reduced

cardiovascular system

abnormal placenta vasculature ( J:68751 )

• at E13.5, the extracellular matrix around fetal blood vessels is fragmented and fetal blood cells are occasionally seen infiltrating the trophoblast layer

cellular

abnormal muscle precursor cell migration ( J:68751 )

• at E10.25, fewer precursor cells are found in the forelimb bud with the dorsal forelimb most strongly affected

Allelic Composition	Gab1^tm1Wbm/Gab1^tm1Wbm
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gab1^tm1Wbm mutation (0 available); any Gab1 mutation (78 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Cleft palate in Gab1^tm3Wbm/Gab1^tm3Wbm, Gab1^tm2Wbm/Gab1^tm2Wbm, Gab1^tm1Wbm/Gab1^tm1Wbm and Gab1^tm3Wbm/Gab1^tm3Wbm Met^tm1Cbm/Met⁺ mice, but not in Gab1^tm4Wbm/Gab1^tm4Wbm mice

craniofacial

cleft secondary palate ( J:125303 )

• at E16, many mice have an open secondary palate

muscle

abnormal skeletal muscle morphology ( J:125303 )

• extensor muscles are missing and muscles reach less far distally

decreased skeletal muscle mass ( J:125303 )

digestive/alimentary system

cleft secondary palate ( J:125303 )

• at E16, many mice have an open secondary palate

growth/size/body

cleft secondary palate ( J:125303 )

• at E16, many mice have an open secondary palate

Allelic Composition	Gab1^tm1Wbm/Gab1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gab1^tm1Wbm mutation (0 available); any Gab1 mutation (78 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:68751 )

• about 5% of heterozygotes develop after spasms 2-3 months of age and die

behavior/neurological

abnormal behavior ( J:68751 )

• about 5% of heterozygotes develop after spasms 2-3 months of age and die

Allelic Composition	Cxcr4^tm1Qma/Cxcr4^tm1Qma Gab1^tm1Wbm/Gab1^tm1Wbm
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcr4^tm1Qma mutation (1 available); any Cxcr4 mutation (46 available)
Gab1^tm1Wbm mutation (0 available); any Gab1 mutation (78 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal muscle precursor cell migration ( J:100909 )

• at E10.75 and E11.5, no hypaxial muscle progenitor cells reach the floor of the first branchial arch

abnormal intrinsic tongue muscle morphology ( J:100909 )

• only a fragment of the intrinsic muscle is present in the proximal tongue

abnormal myogenesis ( J:100909 )

• at E10.75, the number of muscle cells (MyoD+) is further reduced and the number of apoptotic cells is increased in the dorsal and ventral limbs compared to Gab single homozygotes

hypaxial muscle hypoplasia ( J:100909 )

• limb muscle size is reduced and in the proximal portion of the lower forelimb, particular extensor muscles of dorsal limb are absent and the flexor muscles are reduced in size compared to Gab1 single homozygotes

digestive/alimentary system

abnormal intrinsic tongue muscle morphology ( J:100909 )

• only a fragment of the intrinsic muscle is present in the proximal tongue

decreased tongue size ( J:100909 )

• the overall size of the tongue is very small

craniofacial

abnormal intrinsic tongue muscle morphology ( J:100909 )

• only a fragment of the intrinsic muscle is present in the proximal tongue

decreased tongue size ( J:100909 )

• the overall size of the tongue is very small

cellular

abnormal muscle precursor cell migration ( J:100909 )

• at E10.75 and E11.5, no hypaxial muscle progenitor cells reach the floor of the first branchial arch

growth/size/body

abnormal intrinsic tongue muscle morphology ( J:100909 )

• only a fragment of the intrinsic muscle is present in the proximal tongue

decreased tongue size ( J:100909 )

• the overall size of the tongue is very small

Allelic Composition	Gab1^tm1Wbm/Gab1^tm1Wbm Met^tm1Cbm/Met^tm1Cbm
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gab1^tm1Wbm mutation (0 available); any Gab1 mutation (78 available)
Met^tm1Cbm mutation (0 available); any Met mutation (83 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

hypaxial muscle hypoplasia ( J:68751 )

• at E14.5, muscles are virtually absent from all lower limbs

Allelic Composition	Cd44^tm1Mak/Cd44^tm1Mak Gab1^tm1Wbm/Gab1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd44^tm1Mak mutation (1 available); any Cd44 mutation (72 available)
Gab1^tm1Wbm mutation (0 available); any Gab1 mutation (78 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality, incomplete penetrance ( J:128984 )

• shortly after birth, 60% of the animals die

neonatal lethality, incomplete penetrance ( J:128984 )

• shortly after birth, 60% of the animals die

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