mortality/aging
• almost completely resistant to Semliki forest virus induced mortality
|
• homozygotes become ill and die before reaching 3 weeks of age
(J:51281)
• most die by 2 - 3 weeks of age
(J:57474)
• raising mice in germ free conditions does not improve survival
(J:57474)
• mice die from inflammatory disease before weaning
(J:72528)
|
growth/size/body
• homozygotes become smaller within 10 days after birth
|
hematopoietic system
N |
• treatment with an anti-IFNG antibody rescues most of the abnormalities
|
small thymus
(
J:51281
)
• the cortex becomes progressively depleted of lymphoid cells
(J:51281)
• atrophy of the cortex
(J:57474)
|
• lymphopenia in the bone marrow
|
• moderate reduction in platelet numbers
|
• in the bone marrow
|
• moderate reduction in eosinophil numbers
|
• progressive loss of maturing B lymphocytes in the marrow, spleen, and peripheral blood
|
• pre-B cells are depleted significantly in the marrow
|
• number of mature B cells expressing surface Ig in the bone marrow is reduced
|
• lymphoid follicles of the spleen are either completely absent or are composed of immature cells
|
• most spleens show expanded areas of red pulp with nucleated erythroid cells as the main cell population
|
• failure of lymphoid follicle development
|
• stimulation with as little as 0.01 U/ml IFNG is able to maintain efficient macrophage killing of Leishmania major parasites while concentration of less than 0.1 U/ml have little effect on wild-type macrophages
• increase in the capacity to produce NO
|
immune system
small thymus
(
J:51281
)
• the cortex becomes progressively depleted of lymphoid cells
(J:51281)
• atrophy of the cortex
(J:57474)
|
• in the bone marrow
|
• moderate reduction in eosinophil numbers
|
• progressive loss of maturing B lymphocytes in the marrow, spleen, and peripheral blood
|
• pre-B cells are depleted significantly in the marrow
|
• number of mature B cells expressing surface Ig in the bone marrow is reduced
|
• lymphoid follicles of the spleen are either completely absent or are composed of immature cells
|
• most spleens show expanded areas of red pulp with nucleated erythroid cells as the main cell population
|
• failure of lymphoid follicle development
|
• stimulation with as little as 0.01 U/ml IFNG is able to maintain efficient macrophage killing of Leishmania major parasites while concentration of less than 0.1 U/ml have little effect on wild-type macrophages
• increase in the capacity to produce NO
|
• Peyer's patches are present but contain few lymphocytes
|
• lymph nodes show absence of lymphoid follicle formation
|
• infiltration of the liver, lungs, pancreas, heart, and skin with macrophages is seen by P21
|
• mice die from massive generalized inflammation that affects multiple organs
|
• monocytic, and less frequently, granulocytic infiltration
|
• monocytic infiltration
|
• livers exhibit both focal and generalized infiltration, predominantly by immature and mature monocytic and granulocytic cells, and less frequently, megakaryocytes and eosinophils
|
• almost completely resistant to Semliki forest virus induced mortality
|
liver/biliary system
• livers exhibit both focal and generalized infiltration, predominantly by immature and mature monocytic and granulocytic cells, and less frequently, megakaryocytes and eosinophils
|
• at P21
|
• parenchymal cells contain an accumulation of lipid-containing vacuoles
(J:51281)
• at P21 fatty degeneration of liver cells is seen
(J:57474)
|
• fatty degeneration either involves local areas not related to portal vessels or is generalized to the entire liver
|
cardiovascular system
• monocytic, and less frequently, granulocytic infiltration
|
respiratory system
• increase in cellularity of alveolar walls in the lung, often associated with macrophage cuffing around major vessels
|
endocrine/exocrine glands
small thymus
(
J:51281
)
• the cortex becomes progressively depleted of lymphoid cells
(J:51281)
• atrophy of the cortex
(J:57474)
|
• monocytic infiltration
|
integument
• thickening of the epithelium with keratinization at P21
|