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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Socs1tm1Wehi
targeted mutation 1, Walter and Eliza Hall Institute of Medical Research
MGI:1934607
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Socs1tm1Wehi/Socs1tm1Wehi involves: 129S1/Sv * C57BL/6 MGI:2656950
cn2
Socs1tm1Wehi/Socs1tm3Wehi
Tg(Lck-cre)I57Jxm/0
involves: 129P2/OlaHsd * C57BL/6 * ICR MGI:2656984
cx3
Prlrtm1Cnp/Prlr+
Socs1tm1Wehi/Socs1+
involves: 129P2/OlaHsd * 129S1/Sv * 129S2/SvPas * C57BL/6 MGI:4430639
cx4
Ifngtm1Ts/Ifngtm1Ts
Socs1tm1Wehi/Socs1tm1Wehi
involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 MGI:4430638
cx5
Ifngtm1Ts/Ifng+
Socs1tm1Wehi/Socs1tm1Wehi
involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 MGI:4850158


Genotype
MGI:2656950
hm1
Allelic
Composition
Socs1tm1Wehi/Socs1tm1Wehi
Genetic
Background
involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Socs1tm1Wehi mutation (3 available); any Socs1 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Phenotypic abnormalities in Socs1tm1Wehi/Socs1tm1Wehi mice

mortality/aging
• almost completely resistant to Semliki forest virus induced mortality
• homozygotes become ill and die before reaching 3 weeks of age (J:51281)
• most die by 2 - 3 weeks of age (J:57474)
• raising mice in germ free conditions does not improve survival (J:57474)
• mice die from inflammatory disease before weaning (J:72528)

growth/size/body
• homozygotes become smaller within 10 days after birth

hematopoietic system
N
• treatment with an anti-IFNG antibody rescues most of the abnormalities
• the cortex becomes progressively depleted of lymphoid cells (J:51281)
• atrophy of the cortex (J:57474)
• lymphopenia in the bone marrow
• moderate reduction in platelet numbers
• in the bone marrow
• moderate reduction in eosinophil numbers
• progressive loss of maturing B lymphocytes in the marrow, spleen, and peripheral blood
• pre-B cells are depleted significantly in the marrow
• number of mature B cells expressing surface Ig in the bone marrow is reduced
• lymphoid follicles of the spleen are either completely absent or are composed of immature cells
• most spleens show expanded areas of red pulp with nucleated erythroid cells as the main cell population
• failure of lymphoid follicle development
• stimulation with as little as 0.01 U/ml IFNG is able to maintain efficient macrophage killing of Leishmania major parasites while concentration of less than 0.1 U/ml have little effect on wild-type macrophages
• increase in the capacity to produce NO

immune system
• the cortex becomes progressively depleted of lymphoid cells (J:51281)
• atrophy of the cortex (J:57474)
• in the bone marrow
• moderate reduction in eosinophil numbers
• progressive loss of maturing B lymphocytes in the marrow, spleen, and peripheral blood
• pre-B cells are depleted significantly in the marrow
• number of mature B cells expressing surface Ig in the bone marrow is reduced
• lymphoid follicles of the spleen are either completely absent or are composed of immature cells
• most spleens show expanded areas of red pulp with nucleated erythroid cells as the main cell population
• failure of lymphoid follicle development
• stimulation with as little as 0.01 U/ml IFNG is able to maintain efficient macrophage killing of Leishmania major parasites while concentration of less than 0.1 U/ml have little effect on wild-type macrophages
• increase in the capacity to produce NO
• Peyer's patches are present but contain few lymphocytes
• lymph nodes show absence of lymphoid follicle formation
• infiltration of the liver, lungs, pancreas, heart, and skin with macrophages is seen by P21
• mice die from massive generalized inflammation that affects multiple organs
• monocytic, and less frequently, granulocytic infiltration
• monocytic infiltration
• livers exhibit both focal and generalized infiltration, predominantly by immature and mature monocytic and granulocytic cells, and less frequently, megakaryocytes and eosinophils
• almost completely resistant to Semliki forest virus induced mortality

liver/biliary system
• livers exhibit both focal and generalized infiltration, predominantly by immature and mature monocytic and granulocytic cells, and less frequently, megakaryocytes and eosinophils
• at P21
• parenchymal cells contain an accumulation of lipid-containing vacuoles (J:51281)
• at P21 fatty degeneration of liver cells is seen (J:57474)
• fatty degeneration either involves local areas not related to portal vessels or is generalized to the entire liver

cardiovascular system
• monocytic, and less frequently, granulocytic infiltration

respiratory system
• increase in cellularity of alveolar walls in the lung, often associated with macrophage cuffing around major vessels

endocrine/exocrine glands
• the cortex becomes progressively depleted of lymphoid cells (J:51281)
• atrophy of the cortex (J:57474)
• monocytic infiltration

integument
• thickening of the epithelium with keratinization at P21




Genotype
MGI:2656984
cn2
Allelic
Composition
Socs1tm1Wehi/Socs1tm3Wehi
Tg(Lck-cre)I57Jxm/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Socs1tm1Wehi mutation (3 available); any Socs1 mutation (30 available)
Socs1tm3Wehi mutation (2 available); any Socs1 mutation (30 available)
Tg(Lck-cre)I57Jxm mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• enlarged thymic medulla
• increase in thymus cellularity predominately due to an increase in CD8+ T cell population
• enhanced differentiation of thymocytes toward CD8+ T cells
• large reduction in the percentage of non-T cells, mostly B cells, in the lymph nodes
• increase in the ratio of mature CD8 single positive:CD4 single positive thymocytes from 1:4 to 1:1
• increase in the ratio of CD8+:CD4+ T cells in the spleen, however total numbers of T cells are unchanged
• mature thymocytes, both CD4 single positive and CD8 single positive, are larger in size
• increase in CD4+ T cells in the blood
• mature thymocytes, both CD4 single positive and CD8 single positive, are larger in size
• large increase in the percentage and number of CD8 single positive thymocytes at 6 weeks of age
• increase in CD8+ T cells in the blood
• almost all peripheral CD8+ T cells but not CD4+ T cells appear as CD44ho, indicating that they exhibit a memory rather than activated phenotype
• lymph nodes contain 2-fold the number of cells in controls

hematopoietic system
• enlarged thymic medulla
• increase in thymus cellularity predominately due to an increase in CD8+ T cell population
• enhanced differentiation of thymocytes toward CD8+ T cells
• large reduction in the percentage of non-T cells, mostly B cells, in the lymph nodes
• increase in the ratio of mature CD8 single positive:CD4 single positive thymocytes from 1:4 to 1:1
• increase in the ratio of CD8+:CD4+ T cells in the spleen, however total numbers of T cells are unchanged
• mature thymocytes, both CD4 single positive and CD8 single positive, are larger in size
• increase in CD4+ T cells in the blood
• mature thymocytes, both CD4 single positive and CD8 single positive, are larger in size
• large increase in the percentage and number of CD8 single positive thymocytes at 6 weeks of age
• increase in CD8+ T cells in the blood
• almost all peripheral CD8+ T cells but not CD4+ T cells appear as CD44ho, indicating that they exhibit a memory rather than activated phenotype

endocrine/exocrine glands
• enlarged thymic medulla
• increase in thymus cellularity predominately due to an increase in CD8+ T cell population




Genotype
MGI:4430639
cx3
Allelic
Composition
Prlrtm1Cnp/Prlr+
Socs1tm1Wehi/Socs1+
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prlrtm1Cnp mutation (2 available); any Prlr mutation (44 available)
Socs1tm1Wehi mutation (3 available); any Socs1 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
N
• unlike in Prlrtm1Cnp heterozygotes, lobuloalveolar structure development at 2 days postpartum is normal

reproductive system
N
• unlike in Prlrtm1Cnp heterozygotes, lobuloalveolar structure development at 2 days postpartum is normal




Genotype
MGI:4430638
cx4
Allelic
Composition
Ifngtm1Ts/Ifngtm1Ts
Socs1tm1Wehi/Socs1tm1Wehi
Genetic
Background
involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngtm1Ts mutation (18 available); any Ifng mutation (49 available)
Socs1tm1Wehi mutation (3 available); any Socs1 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• unlike mice homozygous for Socs1tm1Wehi alone, double homozygous mice survive past weaning and are overtly healthy (J:57474)
• lethality observed in Socs1tm1Wehi homozygotes is rescued (J:70408)

reproductive system
• from day 16 of pregnancy, mice exhibit a higher density of lobuloalveolar units compared with wild-type mice
• however, proliferation of mammary epithelium is normal

endocrine/exocrine glands
• 8 of 12 mice have enlarged medulla
• however, unlike mice homozygous for Socs1tm1Wehi alone, the cortex is normal
• from day 16 of pregnancy, mice exhibit a higher density of lobuloalveolar units compared with wild-type mice
• however, proliferation of mammary epithelium is normal
• however, lobuloalveolar density returns to normal by day 5 of lactation
• from day 16 of pregnancy, mice exhibit a higher density of lobuloalveolar units compared with wild-type mice
• at day 18 of pregnancy, mammary glands produce more milk than in wild-type mice

cardiovascular system
• 2 of 12 mice show lymphoid cuffing of the lung vessels

hematopoietic system
N
• unlike mice homozygous for Socs1tm1Wehi alone, no hematological abnormalities are detected at 3 weeks of age
• 8 of 12 mice have enlarged medulla
• however, unlike mice homozygous for Socs1tm1Wehi alone, the cortex is normal

immune system
• 8 of 12 mice have enlarged medulla
• however, unlike mice homozygous for Socs1tm1Wehi alone, the cortex is normal

respiratory system
• 2 of 12 mice show lymphoid cuffing of the lung vessels

integument
• from day 16 of pregnancy, mice exhibit a higher density of lobuloalveolar units compared with wild-type mice
• however, proliferation of mammary epithelium is normal
• from day 16 of pregnancy, mice exhibit a higher density of lobuloalveolar units compared with wild-type mice
• however, lobuloalveolar density returns to normal by day 5 of lactation
• at day 18 of pregnancy, mammary glands produce more milk than in wild-type mice




Genotype
MGI:4850158
cx5
Allelic
Composition
Ifngtm1Ts/Ifng+
Socs1tm1Wehi/Socs1tm1Wehi
Genetic
Background
involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngtm1Ts mutation (18 available); any Ifng mutation (49 available)
Socs1tm1Wehi mutation (3 available); any Socs1 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 8 of 12 mice died between 2 and 12 weeks of age, the remaining 4 survived
• 8 of 12 mice died between 2 and 12 weeks of age, the remaining 4 survived





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory