All Phenotypes Flna<Dilp2> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Flna^Dilp2/Flna^Dilp2	involves: BALB/cAnN * C3H/HeN	MGI:2686840
ht2	Flna^Dilp2/Flna⁺	involves: BALB/cAnN * C3H/HeN	MGI:2686843
ht3	Flna^Dilp2/Flna⁺	involves: BALB/cAnN * C3H/HeN * C57BL/6	MGI:3688534
ot4	Flna^Dilp2/Y	involves: BALB/cAnN * C3H/HeN	MGI:2686842
ot5	Flna^Dilp2/Y	involves: BALB/cAnN * C3H/HeN * C57BL/6	MGI:3688533

Allelic Composition	Flna^Dilp2/Flna^Dilp2
Genetic Background	involves: BALB/cAnN * C3H/HeN

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flna^Dilp2 mutation (2 available); any Flna mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:75964 )

Allelic Composition	Flna^Dilp2/Flna⁺
Genetic Background	involves: BALB/cAnN * C3H/HeN

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flna^Dilp2 mutation (2 available); any Flna mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye morphology ( J:75964 )

mydriasis ( J:75964 )

Allelic Composition	Flna^Dilp2/Flna⁺
Genetic Background	involves: BALB/cAnN * C3H/HeN * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flna^Dilp2 mutation (2 available); any Flna mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

double outlet right ventricle ( J:112274 )

• seen in 1 of 8 females

ventricular septal defect ( J:112274 )

• 2 of 8 females exhibit ventricular septal defects

craniofacial

abnormal palatal shelf fusion at midline ( J:112274 )

• in many females, the palatal shelves are elevated correctly, however they remain incompletely fused

skeleton

abnormal sternum morphology ( J:112274 )

• exhibit incomplete fusion of the sternum at E15.5, although with less severity than in males

• although fusion occurs by adulthood, the sternum appears compressed and misshapen and is thicker and shorter than in wild-type

abnormal xiphoid process morphology ( J:112274 )

• abnormal in adult females

vision/eye

irregularly shaped pupil ( J:112274 )

digestive/alimentary system

abnormal palatal shelf fusion at midline ( J:112274 )

• in many females, the palatal shelves are elevated correctly, however they remain incompletely fused

growth/size/body

abnormal palatal shelf fusion at midline ( J:112274 )

• in many females, the palatal shelves are elevated correctly, however they remain incompletely fused

Allelic Composition	Flna^Dilp2/Y
Genetic Background	involves: BALB/cAnN * C3H/HeN

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flna^Dilp2 mutation (2 available); any Flna mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:75964 )

• hemizygous male mice exhibit lethality from this X-linked mutation

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:112274 )

• die by E15.5

cardiovascular system

abnormal cardiac outflow tract development ( J:112274 )

• outflow tract seems to be more centrally located and fails to separate

persistent truncus arteriosus ( J:112274 )

• exhibit a common arterial trunk in which there is no separate aorta and pulmonary artery, but a single vessel that emerges from the right ventricle

double outlet right ventricle ( J:112274 )

thick mitral valve ( J:112274 )

• exhibit thickening of the mitral valve (dysplasia)

ostium primum atrial septal defect ( J:112274 )

• exhibit atrial septal defect primum

ventricular septal defect ( J:112274 )

• exhibit ventricular septal defects

decreased heart right ventricle size ( J:112274 )

craniofacial

cleft secondary palate ( J:112274 )

failure of palatal shelf elevation ( J:112274 )

• palatal shelves fail to elevate at E15.5

homeostasis/metabolism

edema ( J:112274 )

skeleton

abnormal sternum morphology ( J:112274 )

• exhibit incomplete fusion of the sternum at E15.5

digestive/alimentary system

cleft secondary palate ( J:112274 )

failure of palatal shelf elevation ( J:112274 )

• palatal shelves fail to elevate at E15.5

growth/size/body

cleft secondary palate ( J:112274 )

failure of palatal shelf elevation ( J:112274 )

• palatal shelves fail to elevate at E15.5

omphalocele ( J:112274 )

• exhibit umbilical hernia and show delayed resorption of the hernia

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
periventricular nodular heterotopia		DOID:0050454	OMIM:300049 OMIM:608097 OMIM:608098 OMIM:612881 OMIM:615544	J:112274

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