About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Phox2bDilp1
dilated pupils 1
MGI:1934628
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Phox2bDilp1/Phox2bDilp1 involves: BALB/cAnN * C3H/HeN MGI:2686834
ht2
Phox2bDilp1/Phox2b+ involves: BALB/cAnN * C3H/HeN MGI:2686835


Genotype
MGI:2686834
hm1
Allelic
Composition
Phox2bDilp1/Phox2bDilp1
Genetic
Background
involves: BALB/cAnN * C3H/HeN
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phox2bDilp1 mutation (0 available); any Phox2b mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:2686835
ht2
Allelic
Composition
Phox2bDilp1/Phox2b+
Genetic
Background
involves: BALB/cAnN * C3H/HeN
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phox2bDilp1 mutation (0 available); any Phox2b mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• abnormal Mendelian ratios suggested that some heterozygous mice die before weaning

vision/eye
• exhibit no pupillary response to light
• pupils fail to constrict in response to the parasympathetic agonist, carbachol

behavior/neurological
• exhibit no pupillary response to light
• pupils fail to constrict in response to the parasympathetic agonist, carbachol

nervous system
• exhibit severe atrophy of the ciliary ganglia at E13.5
• however, the superior cervical ganglion is normal





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory