All Phenotypes Sdc1<tm1Cma> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sdc1^tm1Cma/Sdc1^tm1Cma	B6.Cg-Sdc1^tm1Cma	MGI:3525353
hm2	Sdc1^tm1Cma/Sdc1^tm1Cma	either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)	MGI:2653535
hm3	Sdc1^tm1Cma/Sdc1^tm1Cma	either: C.Cg-Sdc1^tm1Cma or B6.Cg-Sdc1^tm1Cma	MGI:3525339
hm4	Sdc1^tm1Cma/Sdc1^tm1Cma	involves: 129S4/SvJae	MGI:3717713
hm5	Sdc1^tm1Cma/Sdc1^tm1Cma	involves: 129S4/SvJae * C57BL/6	MGI:3521904
cx6	Sdc1^tm1Cma/Sdc1^tm1Cma Tg(Wnt1)1Hev/0	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:3521901
cx7	Sdc1^tm1Cma/Sdc1⁺ Tg(Wnt1)1Hev/0	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:3521902

Allelic Composition	Sdc1^tm1Cma/Sdc1^tm1Cma
Genetic Background	B6.Cg-Sdc1^tm1Cma

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sdc1^tm1Cma mutation (0 available); any Sdc1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:104294 )

• following skin burning, mice are less susceptible to Pseudomonas aeruginosa infection with 13% of mice dying following treatment while 80% of wild-type mice die 48 hours following treatment

• administration of heparin sulfate increases mortality following burning and infection

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:94010 )

N	• homozygotes display normal heparan sulfate (HS) biosynthesis relative to wild-type • no changes in HS tissue-specific structures are noted in kidney, lung, skin or spleen with respect to disaccharide species or sulfation degree

immune system

decreased susceptibility to bacterial infection ( J:104294 )

• 24 hours following burning and infection, no bacteria are recovered from the liver whereas wild-type livers contain 3.4x10⁵+/-9x10⁴ colony forming units

• 24 hours following burning and infection, no perivascular cuffing or thrombosis is detected whereas the addition of heparin sulfate results in extensive perivascular cuffing

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:104294 )

• following skin burning, mice are less susceptible to Pseudomonas aeruginosa infection with 13% of mice dying following treatment while 80% of wild-type mice die 48 hours following treatment

• administration of heparin sulfate increases mortality following burning and infection

Allelic Composition	Sdc1^tm1Cma/Sdc1^tm1Cma
Genetic Background	either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sdc1^tm1Cma mutation (0 available); any Sdc1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to bacterial infection ( J:69845 )

• at 7 days, mutant newborns are resistant to P. aeruginosa (strain PAO1) lung infection induced through intranasal administration

• mutant newborns exhibit reduced lung and spleen colonization by P. aeruginosa and survive the infection with little or no formation of inflammatory lung foci

• resistance to P. aeruginosa infection can be reversed by administering purified shed syndecan-1 ectodomains or heparin but not heparan sulphate-free syndecan-1 core protein or chondroitin sulphate

• notably, mutant newborns are as susceptible as wild-type mice to P. aeruginosa infection induced through intraperitoneal inoculation

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal cornea wound healing ( J:80682 )

• in response to corneal epithelial wounding, homozygotes re-epithelialize debridement wounds at a slower rate (8-hour delay in the 50% wound closure time relative to wild-type)

• in contrast to wild-type, mutant corneal epithelial cells fail to re-stratify properly by 2 weeks and exhibit prolonged hypoplasia

delayed wound healing ( J:80682 )

• in response to corneal epithelial wounding, homozygotes re-epithelialize debridement wounds at a slower rate (8-hour delay in the 50% wound closure time relative to wild-type)

• in contrast to wild-type, mutant corneal epithelial cells fail to re-stratify properly by 2 weeks and exhibit prolonged hypoplasia

• homozygotes show normal cell migration but delayed re-epithelialization of full-thickness cutaneous wounds; hypoplasia of epithelial tissues within the wound bed is observed

• in response to dermabrasion, homozygotes show delayed skin healing at both 2 and 5 days after wounding

cellular

abnormal cell proliferation ( J:80682 )

• relative to wild-type cells, mutant corneal epithelial cells display a higher cell proliferation rate prior to wounding

• similarly, mutant epidermal keratinocytes proliferate at a significantly higher rate prior to dermabrasion

• wild-type corneal epithelial cells increase proliferation at 24 hours after wounding; in contrast, mutant corneal epithelial cells show reduced localization of alpha9 integrin during closure of wounds and fail to increase their proliferation rate 24 hours after wounding

• at 2 days after dermabrasion, mutant epidermal keratinocytes show only a slight increase in cell proliferation; in wild-type skin, cell proliferation increases >3-fold

• in mutants, extracts from full-thickness skin show increased levels of alpha3 and alpha9 integrins both prior to injury and after hair removal but no increase 2 days after dermabrasion

immune system

increased inflammatory response ( J:80682 )

• after corneal epithelial wounding, homozygotes show a transient increase in inflammatory cells in the corneal stroma

• 18 hours after wounding, more inflammatory cells are found beneath the migrating mutant epithelial sheet than in the wild-type

• in response to dermabrasion, mutant skin wounds appear deeper and tissues more inflamed relative to wild-type

vision/eye

abnormal cornea wound healing ( J:80682 )

• in response to corneal epithelial wounding, homozygotes re-epithelialize debridement wounds at a slower rate (8-hour delay in the 50% wound closure time relative to wild-type)

• in contrast to wild-type, mutant corneal epithelial cells fail to re-stratify properly by 2 weeks and exhibit prolonged hypoplasia

Allelic Composition	Sdc1^tm1Cma/Sdc1^tm1Cma
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sdc1^tm1Cma mutation (0 available); any Sdc1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased IgG1 level ( J:107378 )

• following infection with Trichinella spiralis, IgG1 production is reduced

decreased interleukin-10 secretion ( J:107378 )

• following infection with Trichinella spiralis, IL-10 production is reduced

decreased interleukin-13 secretion ( J:107378 )

• following infection with Trichinella spiralis, IL-13 production is reduced

increased susceptibility to parasitic infection ( J:107378 )

• following infection with Trichinella spiralis, IL-10, IL-13 and IgG1 production is reduced

hematopoietic system

decreased IgG1 level ( J:107378 )

• following infection with Trichinella spiralis, IgG1 production is reduced

Allelic Composition	Sdc1^tm1Cma/Sdc1^tm1Cma
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sdc1^tm1Cma mutation (0 available); any Sdc1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:63122 )

N	• virgin homozygous females exhibit normal mammary gland morphogenesis as well as normal abundance and distribution of mammary myoepithelial cells

reproductive system

reproductive system phenotype ( J:63122 )

N	• homozygotes are fertile and appear phenotypically normal under normal laboratory conditions

Allelic Composition	Sdc1^tm1Cma/Sdc1^tm1Cma Tg(Wnt1)1Hev/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sdc1^tm1Cma mutation (0 available); any Sdc1 mutation (23 available)
Tg(Wnt1)1Hev mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor incidence ( J:63122 )

• only 3% of hemizygous females expressing the transgene in a Sdc1^tm1Cma null background develop mammary tumors (median time: ~36 weeks) versus 34% of hemizygous females in a Sdc1 wild-type background (median time: ~21 weeks)

• these Wnt1-induced tumors are predominantly alveolar adenocarcinomas

endocrine/exocrine glands

mammary gland hyperplasia ( J:63122 )

• hemizygous females expressing the transgene in a Sdc1^tm1Cma null background exhibit a ~70% inhibition of Wnt1-induced mammary gland hyperplasia relative to hemizygous females of a Sdc1 wild-type background

integument

mammary gland hyperplasia ( J:63122 )

Allelic Composition	Sdc1^tm1Cma/Sdc1⁺ Tg(Wnt1)1Hev/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sdc1^tm1Cma mutation (0 available); any Sdc1 mutation (23 available)
Tg(Wnt1)1Hev mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor incidence ( J:63122 )

• 30% of hemizygous females expressing the transgene in a Sdc1^tm1Cma heterozygous null background develop mammary tumors (median time: ~25 weeks) versus 34% of hemizygous females in a Sdc1 wild-type background (median time: ~21 weeks)

• these Wnt1-induced tumors are predominantly alveolar adenocarcinomas

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/17/2024 MGI 6.24