Phenotypes associated with this allele

• Allele Symbol: Hs2st1^{Gt(pGT1.8TM)ST125Nimr}
• Allele Name: gene trap ST125, National Institute for Medical Research
• Allele ID: MGI:1934916
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hs2st1^Gt(pGT1.8TM)ST125Nimr/Hs2st1^Gt(pGT1.8TM)ST125Nimr	involves: 129P2/OlaHsd * C57BL/6	MGI:3606780
hm2	Hs2st1^Gt(pGT1.8TM)ST125Nimr/Hs2st1^Gt(pGT1.8TM)ST125Nimr	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3713110

Genotype
MGI:3606780

hm1

• Allelic Composition: Hs2st1^{Gt(pGT1.8TM)ST125Nimr}/Hs2st1^{Gt(pGT1.8TM)ST125Nimr}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:48481 )

• mutant mice were stillborn or died within 24 hours of birth

renal/urinary system

abnormal kidney development ( J:48481 )

• renal development is arrested

absent kidney ( J:48481 )

• bilateral renal agenesis

abnormal ureteric bud morphology ( J:48481 )

impaired branching involved in ureteric bud morphogenesis ( J:48481 )

• at E11.5, kidney rudiments contain an unbranched uteric bud that is not surrounded by condensed metanephric mesenchyme in contrast to controls

• at E12.5, no branching of the uteric bud is seen with no overt signs of mesenchymal condensation

skeleton

abnormal sternum ossification ( J:48481 )

• ectopic ossification of the sternum

cervical vertebral fusion ( J:48481 )

• vertebral fusions in two of 7 mutants

abnormal bone mineralization ( J:48481 )

• global increase in bone mineralization

limbs/digits/tail

polydactyly ( J:48481 )

• potaxial polydactyly is seen in mutants at high frequency

craniofacial

cleft secondary palate ( J:48481 )

• cleft secondary palate is a frequent observation

vision/eye

abnormal retina pigment epithelium morphology ( J:48481 )

• pertubation of pigmented epithelium differentiation

cataract ( J:48481 )

• six of eight mutant animals have cataracts

abnormal eye development ( J:48481 )

• evidence of retardation of eye development

iris coloboma ( J:48481 )

• bilateral coloboma of the iris

pigmentation

abnormal retina pigment epithelium morphology ( J:48481 )

• pertubation of pigmented epithelium differentiation

digestive/alimentary system

cleft secondary palate ( J:48481 )

• cleft secondary palate is a frequent observation

growth/size/body

cleft secondary palate ( J:48481 )

• cleft secondary palate is a frequent observation

Genotype
MGI:3713110

hm2

• Allelic Composition: Hs2st1^{Gt(pGT1.8TM)ST125Nimr}/Hs2st1^{Gt(pGT1.8TM)ST125Nimr}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

vision/eye

abnormal retina ganglion cell morphology ( J:110040 )

• retinal ganglion cell (RGC) axons are disorganized in and around the chiasm

nervous system

abnormal retina ganglion cell morphology ( J:110040 )

• retinal ganglion cell (RGC) axons are disorganized in and around the chiasm