Phenotypes associated with this allele

• Allele Symbol: Slc12a2^tm1Dlp
• Allele Name: targeted mutation 1, Eric Delpire
• Allele ID: MGI:1935225
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc12a2^tm1Dlp/Slc12a2^tm1Dlp	involves: 129S6/SvEvTac * C57BL/6	MGI:2174738

Genotype
MGI:2174738

hm1

• Allelic Composition: Slc12a2^tm1Dlp/Slc12a2^tm1Dlp
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

postnatal growth retardation ( J:55514 )

• incidence at 1-3 weeks; decreasing severity with age

behavior/neurological

absent startle reflex ( J:55514 )

• absent startle response in acoustic startle test

abnormal motor coordination/balance ( J:55514 )

• decreasing severity with age

weakness ( J:55514 )

• decreasing severity with age

head bobbing ( J:55514 )

hyperactivity ( J:55514 )

circling ( J:55514 )

hearing/vestibular/ear

abnormal cochlea morphology ( J:55514 )

• no division of the cochlear space into scala vestibuli and scala media

collapsed Reissner membrane ( J:55514 )

• completely collapsed towards the stria vascularis epithelium in all turns of the cochlea

abnormal organ of Corti morphology ( J:55514 )

absent cochlear hair cells ( J:55514 )

• already evident at P10

absent organ of Corti supporting cells ( J:55514 )

• absence of outer phalangeal cells, evident at P10

deafness ( J:55514 )

nervous system

absent cochlear hair cells ( J:55514 )

• already evident at P10