Phenotypes associated with this allele

• Allele Symbol: Pdgfrb^tm2Sor
• Allele Name: targeted mutation 2, Philippe Soriano
• Allele ID: MGI:2135519
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pdgfrb^tm2Sor/Pdgfrb^tm2Sor	either: 129S7/SvEvBrd-Pdgfrb^tm2Sor or (involves: 129S7/SvEvBrd * C57BL/6J)	MGI:3693906

Genotype
MGI:3693906

hm1

• Allelic Composition: Pdgfrb^tm2Sor/Pdgfrb^tm2Sor
• Genetic Background: either: 129S7/SvEvBrd-Pdgfrb^tm2Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:20016 )

• some embryos are dead around E16-18.5

perinatal lethality, incomplete penetrance ( J:20016 )

• majority of mutants die perinatally

• cesarean delivered pups die within a matter of minutes of delivery

homeostasis/metabolism

hydrops fetalis ( J:20016 )

• the 1/3 of embryos that exhibit purpura are also edematous

hematopoietic system

anemia ( J:20016 )

abnormal erythrocyte morphology ( J:20016 )

increased nucleated erythrocyte cell number ( J:20016 )

• significantly elevated number of nucleated erythrocytes

anisocytosis ( J:20016 )

poikilocytosis ( J:20016 )

schistocytosis ( J:20016 )

polychromatophilia ( J:20016 )

thrombocytopenia ( J:20016 )

cardiovascular system

decreased glomerular capillary number ( J:20016 )

• capillaries within the renal glomerulus are very scarce

abnormal venule morphology ( J:20016 )

• dilation of veinules

hemorrhage ( J:20016 )

• some cesarean delivered pups suddenly lose most of their blood through the cut in the umbilical cord

kidney hemorrhage ( J:20016 )

• kidney shows specks of blood

• blood cells fill up the capsule space

glomerulus hemorrhage ( J:20016 )

• the capillary tuft normally consisting of podoctyes and mesangial cells is missing in every glomerulus and is replaced with blood cells filling up the capsule space

renal/urinary system

decreased glomerular capillary number ( J:20016 )

• capillaries within the renal glomerulus are very scarce

kidney hemorrhage ( J:20016 )

• kidney shows specks of blood

• blood cells fill up the capsule space

glomerulus hemorrhage ( J:20016 )

• the capillary tuft normally consisting of podoctyes and mesangial cells is missing in every glomerulus and is replaced with blood cells filling up the capsule space

absent mesangial cell ( J:20016 )

• absence, or significant paucity, of mesangial cells

absent podocytes ( J:20016 )

integument

pallor ( J:20016 )

• cesarean delivered pups are pale

purpura ( J:20016 )

• at E16 and E18.5, about 1/3 of embryos exhibit purpura, an accumulation of blood under the surface of the dermis

cellular

absent mesangial cell ( J:20016 )

• absence, or significant paucity, of mesangial cells