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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pdgfrbtm3Sor
targeted mutation 3, Philippe Soriano
MGI:2135532
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pdgfrbtm3Sor/Pdgfrbtm3Sor involves: 129S4/SvJae * C57BL/6 MGI:4421850
ht2
 		Pdgfrbtm1Sor/Pdgfrbtm3Sor involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 MGI:4421854
cx3
 		Pdgfratm5Sor/Pdgfratm5Sor
Pdgfrbtm3Sor/Pdgfrbtm3Sor 		either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6J) MGI:3694481


Genotype
MGI:4421850
hm1
Allelic
Composition		 Pdgfrbtm3Sor/Pdgfrbtm3Sor
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfrbtm3Sor mutation (1 available); any Pdgfrb mutation (87 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal pericyte morphology ( J:86542 )
• decrease in incidence of pericytes in the spinal cord, heart and kidney, compared to wild-type




Genotype
MGI:4421854
ht2
Allelic
Composition		 Pdgfrbtm1Sor/Pdgfrbtm3Sor
Genetic
Background		 involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfrbtm1Sor mutation (1 available); any Pdgfrb mutation (87 available)
Pdgfrbtm3Sor mutation (1 available); any Pdgfrb mutation (87 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal pericyte morphology ( J:86542 )
• 70-92% decrease in pericytes in the kidney and heart




Genotype
MGI:3694481
cx3
Allelic
Composition		 Pdgfratm5Sor/Pdgfratm5Sor
Pdgfrbtm3Sor/Pdgfrbtm3Sor
Genetic
Background		 either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfratm5Sor mutation (1 available); any Pdgfra mutation (87 available)
Pdgfrbtm3Sor mutation (1 available); any Pdgfrb mutation (87 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
midline facial cleft ( J:73817 )
• facial clefting
embryonic growth retardation ( J:73817 )
• a proportion display earlier embryonic defects such as growth retardation

embryo
incomplete embryo turning ( J:73817 )
• in most severe cases, fail to complete turning
embryonic growth retardation ( J:73817 )
• a proportion display earlier embryonic defects such as growth retardation
open neural tube ( J:73817 )
• in most severe cases, fail to complete the fusion of the neural folds by midgestation
failure of chorioallantoic fusion ( J:73817 )
• in most severe cases, fail to complete the fusion of chorion and allantois

craniofacial
midline facial cleft ( J:73817 )
• facial clefting

nervous system
open neural tube ( J:73817 )
• in most severe cases, fail to complete the fusion of the neural folds by midgestation

skeleton

integument
fetal bleb ( J:73817 )
• blebbing along the trunk of the embryo




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory