Phenotypes associated with this allele

• Allele Symbol: Poc1a^cha
• Allele Name: chagun
• Allele ID: MGI:2135614
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Poc1a^cha/Poc1a^cha	B6.D2-Poc1a^cha	MGI:3045433
hm2	Poc1a^cha/Poc1a^cha	involves: DBA/2J	MGI:3045431
hm3	Poc1a^cha/Poc1a^cha	involves: DBA/2J * M. m. castaneus	MGI:3045432

Genotype
MGI:3045433

hm1

• Allelic Composition: Poc1a^cha/Poc1a^cha
• Genetic Background: B6.D2-Poc1a^cha

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:90436 )

• Background Sensitivity: described as lethal at the N6 generation on this background

Genotype
MGI:3045431

hm2

• Allelic Composition: Poc1a^cha/Poc1a^cha
• Genetic Background: involves: DBA/2J

behavior/neurological

limb grasping ( J:90436 )

• animals exhibited a hind limb clasping reflex when lifted by the tail; control mice extended their legs

abnormal gait ( J:90436 )

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:90436 )

♂ • vacuolated structure and reduced number of germ cells

growth/size/body

decreased body weight ( J:90436 )

• at 6 weeks of age, mutants are 75% of the weight of unaffected littermates

decreased body length ( J:90436 )

• the crown-rump length is reduced in mutant mice

disproportionate dwarf ( J:90436 )

• bone length measurements confirm disproportionate dwarfism

postnatal growth retardation ( J:90436 )

• fully penetrant; age of onset at 3 weeks of age and animals are reduced in size as adults

reproductive system

reproductive system phenotype ( J:90436 )

N • females are fertile

azoospermia ( J:90436 )

♂ • absence of mature sperm, with only spermatogonia and spermatocytes present

abnormal seminiferous tubule morphology ( J:90436 )

♂ • vacuolated structure and reduced number of germ cells

arrest of spermatogenesis ( J:90436 )

♂ • absence of mature sperm, with only spermatogonia and spermatocytes present

small gonad ( J:90436 )

• male hypogonadism, fully penetrant; male gonads are half the size of unaffected littermates

male infertility ( J:90436 )

♂

skeleton

abnormal long bone epiphyseal plate morphology ( J:90436 )

• deficiency of chondrocytes in the growth plate and the proliferation zone is not identifiable

• the distal femoral and proximal tibial growth plates are abnormal in shape

abnormal long bone epiphyseal plate proliferative zone ( J:90436 )

• the proliferation zone is not identifiable

decreased long bone epiphyseal plate size ( J:90436 )

• the distal femoral and proximal tibial growth plates are decreased in length

decreased length of long bones ( J:90436 )

• shortened distal long bones length of the femur, humerus, radius, ulna and others

short lumbar vertebrae ( J:90436 )

• reduced in length

cellular

azoospermia ( J:90436 )

♂ • absence of mature sperm, with only spermatogonia and spermatocytes present

Genotype
MGI:3045432

hm3

• Allelic Composition: Poc1a^cha/Poc1a^cha
• Genetic Background: involves: DBA/2J * M. m. castaneus

growth/size/body

postnatal growth retardation ( J:90436 )

• fully penetrant, but less severe than on DBA/2J background; age of onset at 3 weeks of age and animals are reduced in size as adults

reproductive system

small gonad ( J:90436 )

• male hypogonadism; fully penetrant