mortality/aging
• Background Sensitivity: described as lethal at the N6 generation on this background
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Allele Symbol Allele Name Allele ID |
Poc1acha chagun MGI:2135614 |
Summary |
3 genotypes |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• Background Sensitivity: described as lethal at the N6 generation on this background
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• animals exhibited a hind limb clasping reflex when lifted by the tail; control mice extended their legs
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• vacuolated structure and reduced number of germ cells
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• at 6 weeks of age, mutants are 75% of the weight of unaffected littermates
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• the crown-rump length is reduced in mutant mice
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• bone length measurements confirm disproportionate dwarfism
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• fully penetrant; age of onset at 3 weeks of age and animals are reduced in size as adults
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N |
• females are fertile
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• absence of mature sperm, with only spermatogonia and spermatocytes present
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• vacuolated structure and reduced number of germ cells
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• absence of mature sperm, with only spermatogonia and spermatocytes present
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• male hypogonadism, fully penetrant; male gonads are half the size of unaffected littermates
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• deficiency of chondrocytes in the growth plate and the proliferation zone is not identifiable
• the distal femoral and proximal tibial growth plates are abnormal in shape
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• the proliferation zone is not identifiable
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• the distal femoral and proximal tibial growth plates are decreased in length
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• shortened distal long bones length of the femur, humerus, radius, ulna and others
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• reduced in length
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• absence of mature sperm, with only spermatogonia and spermatocytes present
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• fully penetrant, but less severe than on DBA/2J background; age of onset at 3 weeks of age and animals are reduced in size as adults
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• male hypogonadism; fully penetrant
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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