Analysis Tools
behavior/neurological
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• in depression-related paradigms, mutants are more active in the Porsolt's forced-swimming test and in the tail-suspension test and do not become hyperactive after bulbectomy, indicating decreased depression-related behaviors
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• homozygotes are more active and less affected by the light conditions (high light) in the central area of the open-field arena, more active in the open areas of an elevated zero-maze, show reduced latency to feed in the Thatcher-Britton conflict paradigm, and exhibit more social interactions in an aversive environment, all indicators of reduced anxiety
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