Phenotypes associated with this allele

• Allele Symbol: Abcb11^tm1Wng
• Allele Name: targeted mutation 1, Renxue Wang
• Allele ID: MGI:2136289
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Abcb11^tm1Wng/Abcb11^tm1Wng	involves: 129S6/SvEvTac * C57BL/6J	MGI:2653825

Genotype
MGI:2653825

hm1

• Allelic Composition: Abcb11^tm1Wng/Abcb11^tm1Wng
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Hepatocyte and bile canalicular abnormalities in Abcb11^tm1Wng/Abcb11^tm1Wng mice

growth/size/body

decreased body weight ( J:67548 )

• body weight is about 20% lower than in wild-type at weaning and lower weight is seen throughout life

postnatal growth retardation ( J:67548 )

enlarged liver ( J:67548 )

• liver is enlarged to 10.1% of the body weight

homeostasis/metabolism

decreased liver glycogen level ( J:67548 )

• decrease in liver glycogen content

abnormal bile salt level ( J:67548 )

• total concentration of biliary bile salts is reduced more than 4-fold

increased bile salt level ( J:67548 )

• total bile salt concentrations in the liver and plasma are elevated 4- and 5.8-fold, respectively

• mutants exhibit increased amounts of tetra-hydroxylated bile acids

increased cholesterol level ( J:67548 )

• 7-fold increase in biliary cholesterol concentration

abnormal phospholipid level ( J:67548 )

• 2.5-fold increase in biliary phospholipid concentration

liver/biliary system

enlarged liver ( J:67548 )

• liver is enlarged to 10.1% of the body weight

decreased liver glycogen level ( J:67548 )

• decrease in liver glycogen content

abnormal bile canaliculus morphology ( J:67548 )

• dilation of canalicular lumens, partial or complete loss of microvilli, and retention of biliary material

abnormal hepatocyte morphology ( J:67548 )

• increase in peroxisomes, lysosomes, and lipid droplets

abnormal bile secretion ( J:67548 )

• impaired secretion of major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid, however secretion of the more hydrophilic muricholic acids is unaffected

intrahepatic cholestasis ( J:67548 )

• nonprogressive but persistent intrahepatic cholestasis