Phenotypes associated with this allele

• Allele Symbol: Itgae^tm1Cmp
• Allele Name: targeted mutation 1, Christina M Parker
• Allele ID: MGI:2136817
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Itgae^tm1Cmp/Itgae^tm1Cmp	involves: 129S2/SvPas * BALB/c	MGI:2672090

Genotype
MGI:2672090

hm1

• Allelic Composition: Itgae^tm1Cmp/Itgae^tm1Cmp
• Genetic Background: involves: 129S2/SvPas * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased lymphocyte cell number ( J:55333 )

• intestinal and vaginal intraepithelial lymphocyte numbers were reduced; the impact upon intestinal IEL numbers was greater at 3-4 wk of life than in younger animals

decreased T cell number ( J:55333 )

• the TCR beta+ CD8+ T cells were more affected than the TCR beta+ CD4+CD8- population

• lamina propria T lymphocyte numbers were diminished

hematopoietic system

decreased lymphocyte cell number ( J:55333 )

• intestinal and vaginal intraepithelial lymphocyte numbers were reduced; the impact upon intestinal IEL numbers was greater at 3-4 wk of life than in younger animals

decreased T cell number ( J:55333 )

• the TCR beta+ CD8+ T cells were more affected than the TCR beta+ CD4+CD8- population

• lamina propria T lymphocyte numbers were diminished