All Phenotypes Ret<tm2.1Cos> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ret^tm2.1Cos
targeted mutation 2.1, Frank Costantini
MGI:2136896

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ret^tm2.1Cos/Ret^tm2.1Cos	involves: 129S1/Sv	MGI:5489750
hm2	Ret^tm2.1Cos/Ret^tm2.1Cos	involves: 129S1/Sv * C57BL/6J	MGI:3846739
hm3	Ret^tm2.1Cos/Ret^tm2.1Cos	involves: 129S1/Sv * C57BL/6J * FVB/N	MGI:3583331
ht4	Ret^tm2.1Cos/Ret⁺	involves: 129S1/Sv * C57BL/6J * FVB/N	MGI:3583335
ht5	Ret^tm1Cos/Ret^tm2.1Cos	involves: 129S/SvEv * 129S1/Sv * C57BL/6J * FVB/N * MF1	MGI:3583336
cx6	Ret^tm2.1Cos/? Tg(Th-MYCN)41Waw/0	involves: 129S1/Sv * BALB/c * C57BL/6J	MGI:6196323

Allelic Composition	Ret^tm2.1Cos/Ret^tm2.1Cos
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ret^tm2.1Cos mutation (1 available); any Ret mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:195828 )

N	• mice exhibit normal thymopoiesis

Allelic Composition	Ret^tm2.1Cos/Ret^tm2.1Cos
Genetic Background	involves: 129S1/Sv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ret^tm2.1Cos mutation (1 available); any Ret mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased pheochromocytoma incidence ( J:148708 )

• in most mice, normal secretory cells are replaced with abnormal cells with higher density of nuclei and less volume of basophilic cytoplasm suggestive of pheochromocytoma

endocrine/exocrine glands

increased pheochromocytoma incidence ( J:148708 )

• in most mice, normal secretory cells are replaced with abnormal cells with higher density of nuclei and less volume of basophilic cytoplasm suggestive of pheochromocytoma

Allelic Composition	Ret^tm2.1Cos/Ret^tm2.1Cos
Genetic Background	involves: 129S1/Sv * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ret^tm2.1Cos mutation (1 available); any Ret mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal adrenal gland morphology ( J:60659 )

• newborns have bilateral malformations of the adrenal glands

abnormal adrenal medulla morphology ( J:60659 )

• mice show incomplete enclosure of the adrenal medulla

adrenergic chromaffin cell hyperplasia ( J:60659 )

• mice show display nodular chromaffin cell hyperplasia as early as 4 months of age

increased pheochromocytoma incidence ( J:60659 )

• apparent as early as 5 months of age and in every mutant by 6 months of age

thyroid gland hyperplasia ( J:60659 )

• at 6-10 months of age, 26% display diffuse C-cell hyperplasia and 60% display more advanced nodular C-cell hyperplasia

nervous system

adrenergic chromaffin cell hyperplasia ( J:60659 )

• mice show display nodular chromaffin cell hyperplasia as early as 4 months of age

increased ganglioneuroma incidence ( J:60659 )

• develop ganglioneuromas of the adrenal medulla however do not develop ganglioneuromas of the intestinal tract or mucosa

abnormal sympathetic ganglion morphology ( J:60659 )

• consistently display neuromatous enlargement of the sympathetic ganglia along the medial aspect of the adrenal glands and invasion of the sympathetic ganglia into the adrenal gland

neoplasm

increased pheochromocytoma incidence ( J:60659 )

• apparent as early as 5 months of age and in every mutant by 6 months of age

increased ganglioneuroma incidence ( J:60659 )

• develop ganglioneuromas of the adrenal medulla however do not develop ganglioneuromas of the intestinal tract or mucosa

reproductive system

male infertility ( J:60659 )

• 83% of males could not impregnate wild-type females although they exhibited normal mounting behavior and had normal gonads and produced mature sperm

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	familial medullary thyroid carcinoma	DOID:0050547	OMIM:155240	J:60659
multiple endocrine neoplasia type 2B		DOID:10016	OMIM:162300	J:60659
pheochromocytoma		DOID:0050771	OMIM:171300	J:60659

Allelic Composition	Ret^tm2.1Cos/Ret⁺
Genetic Background	involves: 129S1/Sv * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ret^tm2.1Cos mutation (1 available); any Ret mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

adrenergic chromaffin cell hyperplasia ( J:60659 )

• 16-17% display nodular chromaffin cell hyperplasia, rarely progressing to pheochromocytoma

thyroid gland hyperplasia ( J:60659 )

• 31% of young and 41% of older mutants display diffuse C-cell hyperplasia and 14% have more advanced nodular C-cell hyperplasia

nervous system

adrenergic chromaffin cell hyperplasia ( J:60659 )

• 16-17% display nodular chromaffin cell hyperplasia, rarely progressing to pheochromocytoma

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	familial medullary thyroid carcinoma	DOID:0050547	OMIM:155240	J:60659
multiple endocrine neoplasia type 2B		DOID:10016	OMIM:162300	J:60659

Allelic Composition	Ret^tm1Cos/Ret^tm2.1Cos
Genetic Background	involves: 129S/SvEv * 129S1/Sv * C57BL/6J * FVB/N * MF1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ret^tm1Cos mutation (2 available); any Ret mutation (54 available)
Ret^tm2.1Cos mutation (1 available); any Ret mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:60659 )

N	• do not exhibit ganglioneuromas, nodular chromaffin cell hyperplasia or pheochromocytomas

reproductive system

reproductive system phenotype ( J:60659 )

N	• males are fertile

neoplasm

neoplasm ( J:60659 )

N	• do not exhibit ganglioneuromas or pheochromocytomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	multiple endocrine neoplasia type 2B	DOID:10016	OMIM:162300	J:60659
NOT	pheochromocytoma	DOID:0050771	OMIM:171300	J:60659

Allelic Composition	Ret^tm2.1Cos/? Tg(Th-MYCN)41Waw/0
Genetic Background	involves: 129S1/Sv * BALB/c * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ret^tm2.1Cos mutation (1 available); any Ret mutation (54 available)
Tg(Th-MYCN)41Waw mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:261033 )

• mice begin to die around 100 days of age, with 50% survival at 250 days of age

neoplasm

increased neuroblastoma incidence ( J:261033 )

• mice develop stroma-poor neuroblastoma, with the majority of tumors showing signs of differentiation

nervous system

increased neuroblastoma incidence ( J:261033 )

• mice develop stroma-poor neuroblastoma, with the majority of tumors showing signs of differentiation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
neuroblastoma		DOID:769		J:261033

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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