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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il15tm1Imx
targeted mutation 1, Immunex Research and Development Corporation
MGI:2136897
Summary 13 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Il15tm1Imx/Il15tm1Imx C57BL/6-Il15tm1Imx MGI:3769354
hm2
 		Il15tm1Imx/Il15tm1Imx C57BL/6-Il15tm1Imx/Tac MGI:3771840
hm3
 		Il15tm1Imx/Il15tm1Imx involves: C57BL/6 MGI:3590155
cn4
 		Il15tm1Imx/Il15tm1Imx
Il7rtm1.1Asin/Il7rtm1Imx
Tg(Cd8a*-cre)B8Asin/0 		involves: 129S7/SvEvBrd * C57BL/6 MGI:5469009
cx5
 		Il15tm1Imx/Il15tm1Imx
X/Yaa 		BXSB.B6-Il15tm1Imx/Dcr MGI:6105930
cx6
 		Cd8atm1Mak/Cd8atm1Mak
Il15tm1Imx/Il15tm1Imx
X/Yaa 		BXSB.Cg-Cd8atm1Mak Il15tm1Imx/Dcr MGI:6105946
cx7
 		Il15tm1Imx/Il15tm1Imx
Itktm1Ljb/Itktm1Ljb 		involves: 129 * C57BL/6 * C57BL/10 MGI:4354590
cx8
 		Il15tm1Imx/Il15+
Myctm1Atp/Myc+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:3811833
cx9
 		Il15tm1Imx/Il15tm1Imx
Myctm1Atp/Myc+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:3811834
cx10
 		Il15tm1Imx/Il15tm1Imx
Itktm1Litt/Itktm1Litt 		involves: 129S4/SvJae * C57BL/6 MGI:3771841
cx11
 		Il15tm1Imx/Il15tm1Imx
Rag2tm1Fwa/Rag2tm1Fwa 		involves: 129S/SvEv * C57BL/6 MGI:3776483
cx12
 		Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Il15tm1Imx/Il15tm1Imx 		involves: C57BL/6 MGI:5562714
cx13
 		Eomestm1.1Twa/?
Il15tm1Imx/Il15tm1Imx 		involves: C57BL/6 * C57BL/6N MGI:5699434


Genotype
MGI:3769354
hm1
Allelic
Composition		 Il15tm1Imx/Il15tm1Imx
Genetic
Background		 C57BL/6-Il15tm1Imx
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il15tm1Imx mutation (5 available); any Il15 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal dendritic cell physiology ( J:123902 )
• in culture, dendritic cells are resistant to cytokine withdrawal-induced apoptosis




Genotype
MGI:3771840
hm2
Allelic
Composition		 Il15tm1Imx/Il15tm1Imx
Genetic
Background		 C57BL/6-Il15tm1Imx/Tac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il15tm1Imx mutation (5 available); any Il15 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal thymus cell ratio ( J:111786 )
• number of CD8 single-positive thymocytes is decreased relative to wild-type at 3 weeks of age
• absolute number of CD122hi cells are decreased in number among CD8+ cells at all stages of T cell maturation compared to wild-type
• at mature CD40lo stage, CD122hi CD8 SP T cells are almost undetectable in thymi
abnormal CD8-positive, alpha-beta T cell differentiation ( J:111786 )
• defects in thymic development of mature CD44hiCD122hiCD8+ T cells are detected
decreased CD8-positive, alpha-beta T cell number ( J:111786 )
• in blood, mice exhibit strong reduction in CD8+CD44hiCD122hi T cells and total peripheral CD8+ T cell number is reduced by 40-50% compared to wild-type

hematopoietic system
abnormal thymus cell ratio ( J:111786 )
• number of CD8 single-positive thymocytes is decreased relative to wild-type at 3 weeks of age
• absolute number of CD122hi cells are decreased in number among CD8+ cells at all stages of T cell maturation compared to wild-type
• at mature CD40lo stage, CD122hi CD8 SP T cells are almost undetectable in thymi
abnormal CD8-positive, alpha-beta T cell differentiation ( J:111786 )
• defects in thymic development of mature CD44hiCD122hiCD8+ T cells are detected
decreased CD8-positive, alpha-beta T cell number ( J:111786 )
• in blood, mice exhibit strong reduction in CD8+CD44hiCD122hi T cells and total peripheral CD8+ T cell number is reduced by 40-50% compared to wild-type

endocrine/exocrine glands
abnormal thymus cell ratio ( J:111786 )
• number of CD8 single-positive thymocytes is decreased relative to wild-type at 3 weeks of age
• absolute number of CD122hi cells are decreased in number among CD8+ cells at all stages of T cell maturation compared to wild-type
• at mature CD40lo stage, CD122hi CD8 SP T cells are almost undetectable in thymi




Genotype
MGI:3590155
hm3
Allelic
Composition		 Il15tm1Imx/Il15tm1Imx
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il15tm1Imx mutation (5 available); any Il15 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to bacterial infection induced morbidity/mortality ( J:84009 )
• improved survival after infection with Listeria monocytogenes

immune system
decreased dendritic cell number ( J:97620 )
• lower numbers of splenic dendritc cells after Plasmodium chabaudi infection
abnormal lymphocyte morphology ( J:60915 )
• Intestinal intraepithelial lymphocytes maturing outside of the thymus are greatly reduced in numbers
decreased NK cell number ( J:60915 , J:132730 , J:142654 )
• reduced numbers of natural killer cells in thymus, liver and spleen (J:60915)
• NK cell numbers in the intestine are reduced by 100-fold (J:142654)
• however, the Ncr(NKp46)+CD127+ NK1.1- subset of intestinal natural killer cells is unaffected (J:142654)
absent uterine NK cells ( J:84009 )
• absent in uterus
decreased CD8-positive, alpha-beta T cell number ( J:60915 , J:113408 )
• two fold reduction in numbers of CD8 single positive cells in spleen and lymph nodes (J:60915)
• there is a 2-fold loss in total CD8+ T cell numbers and a 3-fold reduction in numbers of CD8+CD44hi T cells (J:113408)
small lymph nodes ( J:60915 )
• periferal lymph nodes significantly lower in weight
• decreased cellularity
decreased immunoglobulin level ( J:97620 )
• lower levels of malaria specific antibodies produced
• lower levels of total immune globulin
decreased IgG level ( J:97620 )
• decreased levels of IgG1, IgG2a, IgG2b, and IgG3 after Plasmodium infection
decreased IgM level ( J:97620 )
• after plasmodium infection
impaired natural killer cell mediated cytotoxicity ( J:97620 )
• significantly reduced cytolytic activity
abnormal CD8-positive, alpha-beta T cell physiology ( J:95221 )
• CD8+ T cell proliferation in vitro is not enhanced in the presence of IL-21 in the same manner as wild-type CD8+ T cells
decreased susceptibility to type IV hypersensitivity reaction ( J:87137 )
• no contact hypersensitivity
• T mediated effects delayed but not B cell activation or antibody production
decreased interferon-gamma secretion ( J:97620 )
• reduced production of IFN gamma by NK cells
decreased interleukin-12 secretion ( J:97620 )
• reduced Il12 production by dendritic cells after Plasmodium infection
decreased susceptibility to bacterial infection induced morbidity/mortality ( J:84009 )
• improved survival after infection with Listeria monocytogenes
increased susceptibility to parasitic infection ( J:97620 )
• parasitemia higher but only minor effect on mortality

reproductive system
absent uterine NK cells ( J:84009 )
• absent in uterus
abnormal decidualization ( J:84009 )
• marked acellularity of decidua relative to controls
• thickened decidual arteries at days 12 and 14 of pregnancy

cardiovascular system
abnormal uterine artery morphology ( J:84009 )
• thickened decidual arteries at days 12 and 14 of pregnancy
• decidual artery walls thickened and lumen narrowed
• first evidence of abnormality at day 10 of pregnancy and worsening with time

growth/size/body
decreased body weight ( J:84009 )
• slight but significant reduction in weight at birth

hematopoietic system
decreased dendritic cell number ( J:97620 )
• lower numbers of splenic dendritc cells after Plasmodium chabaudi infection
abnormal lymphocyte morphology ( J:60915 )
• Intestinal intraepithelial lymphocytes maturing outside of the thymus are greatly reduced in numbers
decreased NK cell number ( J:60915 , J:132730 , J:142654 )
• reduced numbers of natural killer cells in thymus, liver and spleen (J:60915)
• NK cell numbers in the intestine are reduced by 100-fold (J:142654)
• however, the Ncr(NKp46)+CD127+ NK1.1- subset of intestinal natural killer cells is unaffected (J:142654)
absent uterine NK cells ( J:84009 )
• absent in uterus
decreased CD8-positive, alpha-beta T cell number ( J:60915 , J:113408 )
• two fold reduction in numbers of CD8 single positive cells in spleen and lymph nodes (J:60915)
• there is a 2-fold loss in total CD8+ T cell numbers and a 3-fold reduction in numbers of CD8+CD44hi T cells (J:113408)
decreased immunoglobulin level ( J:97620 )
• lower levels of malaria specific antibodies produced
• lower levels of total immune globulin
decreased IgG level ( J:97620 )
• decreased levels of IgG1, IgG2a, IgG2b, and IgG3 after Plasmodium infection
decreased IgM level ( J:97620 )
• after plasmodium infection
impaired natural killer cell mediated cytotoxicity ( J:97620 )
• significantly reduced cytolytic activity
abnormal CD8-positive, alpha-beta T cell physiology ( J:95221 )
• CD8+ T cell proliferation in vitro is not enhanced in the presence of IL-21 in the same manner as wild-type CD8+ T cells

embryo
absent uterine NK cells ( J:84009 )
• absent in uterus
abnormal decidualization ( J:84009 )
• marked acellularity of decidua relative to controls
• thickened decidual arteries at days 12 and 14 of pregnancy

endocrine/exocrine glands
absent uterine NK cells ( J:84009 )
• absent in uterus




Genotype
MGI:5469009
cn4
Allelic
Composition		 Il15tm1Imx/Il15tm1Imx
Il7rtm1.1Asin/Il7rtm1Imx
Tg(Cd8a*-cre)B8Asin/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il15tm1Imx mutation (5 available); any Il15 mutation (44 available)
Il7rtm1.1Asin mutation (1 available); any Il7r mutation (31 available)
Il7rtm1Imx mutation (4 available); any Il7r mutation (31 available)
Tg(Cd8a*-cre)B8Asin mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD8-positive, alpha-beta T cell number ( J:190889 )
• in the thymus and periphery, worse than in Il7rtm1.1Asin/Il7rtm1Imx Tg(Cd8a*-cre)#Asin mice

hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:190889 )
• in the thymus and periphery, worse than in Il7rtm1.1Asin/Il7rtm1Imx Tg(Cd8a*-cre)#Asin mice




Genotype
MGI:6105930
cx5
Allelic
Composition		 Il15tm1Imx/Il15tm1Imx
X/Yaa
Genetic
Background		 BXSB.B6-Il15tm1Imx/Dcr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il15tm1Imx mutation (5 available); any Il15 mutation (44 available)
Yaa mutation (24 available); any Yaa mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to systemic lupus erythematosus ( J:179430 )
• while BXSB/MpJ males develop SLE-like disease and have a mean survival of 32 weeks, males also homozygous for this null allele of beta-2 microglobulin die much earlier, with a mean survival of only approximately 20 weeks

mortality/aging




Genotype
MGI:6105946
cx6
Allelic
Composition		 Cd8atm1Mak/Cd8atm1Mak
Il15tm1Imx/Il15tm1Imx
X/Yaa
Genetic
Background		 BXSB.Cg-Cd8atm1Mak Il15tm1Imx/Dcr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd8atm1Mak mutation (7 available); any Cd8a mutation (39 available)
Il15tm1Imx mutation (5 available); any Il15 mutation (44 available)
Yaa mutation (24 available); any Yaa mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

renal/urinary system
renal glomerular immunoglobulin deposits ( J:179430 )
• glomerular deposition of IgG at 14 weeks of age is more severe than that of BXSB/MpJ males

immune system
increased monocyte cell number ( J:179430 )
• at 14 weeks of age relative to BSXB/MpJ or BXSB.B6=Yaa+ males
abnormal spleen B cell follicle morphology ( J:179430 )
• scattered follicular distribution in the spleen and large extrafollicular accumulations of CD138+ plasma cells and plasmablasts are found at 14 weeks of age
increased splenocyte number ( J:179430 )
• by 14 weeks of age compared with BXSB/MpJ males and the splenocytes have an increased proportion of monocytes, increased ICOS expression on CD4+ T cells, and increased FAS expression on B cells
increased IgG1 level ( J:179430 )
• significantly higher than BXSB/MpJ males as early as 4 weeks of age, the earliest timepoint assessed
increased IgG2a level ( J:179430 )
• elevated earlier and significantly higher than BXSB/MpJ males as early as 4 weeks of age, the earliest timepoint assessed
increased IgG2b level ( J:179430 )
• elevated earlier and significantly higher than BXSB/MpJ males as early as 4 weeks of age, the earliest timepoint assessed
increased susceptibility to systemic lupus erythematosus ( J:179430 )
• while BXSB/MpJ males develop SLE-like disease and have a mean survival of 32 weeks, males homozygous for both null alleles die earlier than those with just one null allele and with a survival curve essentially the same as that of beta 2 microglobulin null Yaa carrying males, with a mean survival of only 18 weeks
increased anti-nuclear antigen antibody level ( J:179430 )
• elevated over BXSB/MpJ males at 6 and 14 weeks of age

hematopoietic system
increased monocyte cell number ( J:179430 )
• at 14 weeks of age relative to BSXB/MpJ or BXSB.B6=Yaa+ males
abnormal spleen B cell follicle morphology ( J:179430 )
• scattered follicular distribution in the spleen and large extrafollicular accumulations of CD138+ plasma cells and plasmablasts are found at 14 weeks of age
increased splenocyte number ( J:179430 )
• by 14 weeks of age compared with BXSB/MpJ males and the splenocytes have an increased proportion of monocytes, increased ICOS expression on CD4+ T cells, and increased FAS expression on B cells
increased IgG1 level ( J:179430 )
• significantly higher than BXSB/MpJ males as early as 4 weeks of age, the earliest timepoint assessed
increased IgG2a level ( J:179430 )
• elevated earlier and significantly higher than BXSB/MpJ males as early as 4 weeks of age, the earliest timepoint assessed
increased IgG2b level ( J:179430 )
• elevated earlier and significantly higher than BXSB/MpJ males as early as 4 weeks of age, the earliest timepoint assessed




Genotype
MGI:4354590
cx7
Allelic
Composition		 Il15tm1Imx/Il15tm1Imx
Itktm1Ljb/Itktm1Ljb
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/10
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il15tm1Imx mutation (5 available); any Il15 mutation (44 available)
Itktm1Ljb mutation (0 available); any Itk mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:113408 )
• the altered CD8+ T cell development that generates a large proportion of memory T cells in homozygote Itktm1Ljb thymus does not occur in these mice
• there is a 23-fold reduction in peripheral CD8+ T cells compared to wild-type mice and a 7-fold reduction compared to IL-15-sufficient Itktm1Ljb homozygotes

immune system
decreased CD8-positive, alpha-beta T cell number ( J:113408 )
• the altered CD8+ T cell development that generates a large proportion of memory T cells in homozygote Itktm1Ljb thymus does not occur in these mice
• there is a 23-fold reduction in peripheral CD8+ T cells compared to wild-type mice and a 7-fold reduction compared to IL-15-sufficient Itktm1Ljb homozygotes




Genotype
MGI:3811833
cx8
Allelic
Composition		 Il15tm1Imx/Il15+
Myctm1Atp/Myc+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il15tm1Imx mutation (5 available); any Il15 mutation (44 available)
Myctm1Atp mutation (0 available); any Myc mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased memory T cell number ( J:132730 )
• the number of CD8+ CD44high memory T cells is decreased compared to in wild-type mice or single heterogyzotes

immune system
decreased memory T cell number ( J:132730 )
• the number of CD8+ CD44high memory T cells is decreased compared to in wild-type mice or single heterogyzotes




Genotype
MGI:3811834
cx9
Allelic
Composition		 Il15tm1Imx/Il15tm1Imx
Myctm1Atp/Myc+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il15tm1Imx mutation (5 available); any Il15 mutation (44 available)
Myctm1Atp mutation (0 available); any Myc mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased memory T cell number ( J:132730 )
• mice exhibit the same reduction in CD8+ CD44high memory T cells as in Il15tm1Imx Myctm1Atp heterozygotes

hematopoietic system
decreased memory T cell number ( J:132730 )
• mice exhibit the same reduction in CD8+ CD44high memory T cells as in Il15tm1Imx Myctm1Atp heterozygotes




Genotype
MGI:3771841
cx10
Allelic
Composition		 Il15tm1Imx/Il15tm1Imx
Itktm1Litt/Itktm1Litt
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il15tm1Imx mutation (5 available); any Il15 mutation (44 available)
Itktm1Litt mutation (2 available); any Itk mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal thymus cell ratio ( J:111786 )
• number of CD24int CD8 SP thymocytes is less than that seen in Il15-null thymi at 3 weeks of age
• absolute number of CD122hi cells is reduced in number among CD8+ T cells at all stages of T cell development compared to Itk-single null thymi

hematopoietic system
abnormal thymus cell ratio ( J:111786 )
• number of CD24int CD8 SP thymocytes is less than that seen in Il15-null thymi at 3 weeks of age
• absolute number of CD122hi cells is reduced in number among CD8+ T cells at all stages of T cell development compared to Itk-single null thymi

endocrine/exocrine glands
abnormal thymus cell ratio ( J:111786 )
• number of CD24int CD8 SP thymocytes is less than that seen in Il15-null thymi at 3 weeks of age
• absolute number of CD122hi cells is reduced in number among CD8+ T cells at all stages of T cell development compared to Itk-single null thymi




Genotype
MGI:3776483
cx11
Allelic
Composition		 Il15tm1Imx/Il15tm1Imx
Rag2tm1Fwa/Rag2tm1Fwa
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il15tm1Imx mutation (5 available); any Il15 mutation (44 available)
Rag2tm1Fwa mutation (45 available); any Rag2 mutation (119 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased NK cell number ( J:132257 )
• 100-fold less NK cells are found in the spleen 5 days after transfer into these recipient mice compared to control mice
• the remaining NK cells have not proliferated within the first 3 days of transfer
• NK cells isolated from Tg(BCL2)25Wehi have a 2.5 fold higher survival rate 5 days after transfer into these recipient mice

hematopoietic system
decreased NK cell number ( J:132257 )
• 100-fold less NK cells are found in the spleen 5 days after transfer into these recipient mice compared to control mice
• the remaining NK cells have not proliferated within the first 3 days of transfer
• NK cells isolated from Tg(BCL2)25Wehi have a 2.5 fold higher survival rate 5 days after transfer into these recipient mice




Genotype
MGI:5562714
cx12
Allelic
Composition		 Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Il15tm1Imx/Il15tm1Imx
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm1.1Ast mutation (4 available); any Bcl2l11 mutation (36 available)
Il15tm1Imx mutation (5 available); any Il15 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:208318 )
N
• middle-aged mice exhibit a rescue of regulatory T cells compared with Il15tm1Imx homozygotes




Genotype
MGI:5699434
cx13
Allelic
Composition		 Eomestm1.1Twa/?
Il15tm1Imx/Il15tm1Imx
Genetic
Background		 involves: C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eomestm1.1Twa mutation (1 available); any Eomes mutation (44 available)
Il15tm1Imx mutation (5 available); any Il15 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal NK cell differentiation ( J:210160 )
• Eomes- NK cells are lacking
• Eomes+ NK cells are lacking

hematopoietic system
abnormal NK cell differentiation ( J:210160 )
• Eomes- NK cells are lacking
• Eomes+ NK cells are lacking




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory