Phenotypes associated with this allele

• Allele Symbol: Bmp6^tm1Rob
• Allele Name: targeted mutation 1, Elizabeth J Robertson
• Allele ID: MGI:2136985
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bmp6^tm1Rob/Bmp6^tm1Rob	either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J)	MGI:2658718
cx2	Bmp5^se/Bmp5^se Bmp6^tm1Rob/Bmp6^tm1Rob	involves: 129S/SvEv	MGI:3811522

Genotype
MGI:2658718

hm1

• Allelic Composition: Bmp6^tm1Rob/Bmp6^tm1Rob
• Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal sternum manubrium morphology ( J:48561 )

• cartillage of manubrium is about half normal width at E 16.5

abnormal sternum ossification ( J:48561 )

• ossification delayed

• sternal elements delayed 24 hours at E16.5 and ossification is completely absent

• ossification delays continue at E17.5 and E19.5

• sterna are almost completely nornmal at 12 days of age

Genotype
MGI:3811522

cx2

• Allelic Composition: Bmp5^se/Bmp5^se; Bmp6^tm1Rob/Bmp6^tm1Rob
• Genetic Background: involves: 129S/SvEv

growth/size/body

postnatal growth retardation ( J:48561 )

• slight growth reduction

skeleton

abnormal sternum morphology ( J:48561 )

• delayed fusion of sternal bands

abnormal xiphoid process morphology ( J:48561 )

small xiphoid process ( J:48561 )

• reduced xiphoid process at E17.5

split xiphoid process ( J:48561 )

• at E17.5

abnormal sternum ossification ( J:48561 )

• at E17.5

reproductive system

male infertility ( J:48561 )

♂ • males are sterile whereas females are fertile