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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nrp2tm1Ddg
targeted mutation 1, David D Ginty
MGI:2137037
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nrp2tm1Ddg/Nrp2tm1Ddg involves: C57BL/6 MGI:4429924
hm2
 		Nrp2tm1Ddg/Nrp2tm1Ddg Not Specified MGI:5007633
cn3
 		Nrp1tm2Ddg/Nrp1tm2Ddg
Nrp2tm1Ddg/Nrp2tm1Ddg
Tg(Prrx1-cre)1Cjt/0 		involves: 129 * C57BL/6J * SJL/J MGI:3840961
cx4
 		Nrp1tm1Ddg/Nrp1tm1Ddg
Nrp2tm1Ddg/Nrp2tm1Ddg 		involves: 129P2/OlaHsd MGI:3528190
cx5
 		Nrp1tm1Ddg/Nrp1tm1Ddg
Nrp2tm1Ddg/Nrp2tm1Ddg 		involves: 129P2/OlaHsd * C57BL/6 MGI:3512128
cx6
 		Kdrtm1.1Eia/Kdr+
Nrp2tm1Ddg/Nrp2+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:4429919
cx7
 		Flt4tm1Ali/Flt4+
Nrp2tm1Ddg/Nrp2+ 		involves: C57BL/6 MGI:4429922
cx8
 		Flt4tm1Ali/Flt4+
Nrp2tm1Ddg/Nrp2tm1Ddg 		involves: C57BL/6 MGI:4429925


Genotype
MGI:4429924
hm1
Allelic
Composition		 Nrp2tm1Ddg/Nrp2tm1Ddg
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrp2tm1Ddg mutation (0 available); any Nrp2 mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Defective lymphatic sprouting in Nrp2tm1Ddg/Nrp2+ Flt4tm1Ali/Flt4+ and Nrp2tm1Ddg/Nrp2tm1Ddg mice

cellular
decreased cell proliferation ( J:156869 )
• reduced proliferation in lymphatic endothelial cells by phospho-Histone 3 staining of the dorsal trunk skin at P0

immune system
abnormal lymphangiogenesis ( J:156869 )
• reduced lymphatic vascular coverage in the skin of the head at E13.5
• abnormal morphology of lymphatic vessel sprouts at the surface of the heart at P0
• 50% reduction in the number of branch points in the skin at P0
• poorly branched lymphatic vessels, enlarged lymphatic vessels and rare lymphatic tips in the skin at P0
• only the inner collecting layer on tail lymphatics developes at P6




Genotype
MGI:5007633
hm2
Allelic
Composition		 Nrp2tm1Ddg/Nrp2tm1Ddg
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrp2tm1Ddg mutation (0 available); any Nrp2 mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:172268 )
N
• mice exhibit normal retinal stratification




Genotype
MGI:3840961
cn3
Allelic
Composition		 Nrp1tm2Ddg/Nrp1tm2Ddg
Nrp2tm1Ddg/Nrp2tm1Ddg
Tg(Prrx1-cre)1Cjt/0
Genetic
Background		 involves: 129 * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrp1tm2Ddg mutation (1 available); any Nrp1 mutation (82 available)
Nrp2tm1Ddg mutation (0 available); any Nrp2 mutation (88 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:147285 )
N
• no major abnormalities in limb vascular patterning are detected at E13.5




Genotype
MGI:3528190
cx4
Allelic
Composition		 Nrp1tm1Ddg/Nrp1tm1Ddg
Nrp2tm1Ddg/Nrp2tm1Ddg
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrp1tm1Ddg mutation (2 available); any Nrp1 mutation (82 available)
Nrp2tm1Ddg mutation (0 available); any Nrp2 mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
persistent truncus arteriosus ( J:95697 )
• persistent truncus arteriosis is seen; however, somitic vasculature is normal




Genotype
MGI:3512128
cx5
Allelic
Composition		 Nrp1tm1Ddg/Nrp1tm1Ddg
Nrp2tm1Ddg/Nrp2tm1Ddg
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrp1tm1Ddg mutation (2 available); any Nrp1 mutation (82 available)
Nrp2tm1Ddg mutation (0 available); any Nrp2 mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
persistent truncus arteriosus ( J:93799 )
• 66% of mutants exhibited truncus arteriosis compared to none in either single homozygous mutants
increased heart atrium size ( J:93799 )
• exhibited bilateral atrial enlargement




Genotype
MGI:4429919
cx6
Allelic
Composition		 Kdrtm1.1Eia/Kdr+
Nrp2tm1Ddg/Nrp2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdrtm1.1Eia mutation (0 available); any Kdr mutation (73 available)
Nrp2tm1Ddg mutation (0 available); any Nrp2 mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:156869 )
N
• no obvious alteration in capillary density or patterning
• normal lymphatic vessel patterning and sprouting




Genotype
MGI:4429922
cx7
Allelic
Composition		 Flt4tm1Ali/Flt4+
Nrp2tm1Ddg/Nrp2+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt4tm1Ali mutation (1 available); any Flt4 mutation (76 available)
Nrp2tm1Ddg mutation (0 available); any Nrp2 mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Abnormal lymphatic development in Nrp2tm1Ddg/Nrp2+ Flt4tm1Ali/Flt4+ mice

mortality/aging
prenatal lethality, incomplete penetrance ( J:156869 )
• recovered at reduced Mendelian ratios at birth

homeostasis/metabolism
skin edema ( J:156869 )
• edema formation observed by histology at E13.5
• severe edema formation from E15.5 onward

immune system
abnormal lymphangiogenesis ( J:156869 )
• poorly branched lymphatic vessels and rare lymphatic tips in the skin at P0
• 50% reduction in the number of branch points in the skin at P0
• reduced lymph vessel branching in hearts, ears and diaphragm at 2 months
• tail dermal lymphatics are missing until at least P6
• reduced lymphatic vascular coverage in the skin at E13.5
• reduced sprouting and enlarged lymphatic vessels in the skin at E13.5, in the tail at P1, in the heart at P5 and in the small intestine at P4

integument
skin edema ( J:156869 )
• edema formation observed by histology at E13.5
• severe edema formation from E15.5 onward




Genotype
MGI:4429925
cx8
Allelic
Composition		 Flt4tm1Ali/Flt4+
Nrp2tm1Ddg/Nrp2tm1Ddg
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt4tm1Ali mutation (1 available); any Flt4 mutation (76 available)
Nrp2tm1Ddg mutation (0 available); any Nrp2 mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal lymphangiogenesis ( J:156869 )
• enlarged lymph vessel in the dorsal trunk skin at P0
• poor branching in the dorsal trunk skin at P0 (<5%, compare with wild-type)




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/05/2024
MGI 6.24 		The Jackson Laboratory