All Phenotypes Gja8<tm1Scr> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gja8^tm1Scr
targeted mutation 1, The Scripps Institute
MGI:2137525

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Gja8^L1/Gja8^tm1Scr	involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J	MGI:3811921
ht2	Gja8^R205G/Gja8^tm1Scr	involves: 129S1/Sv * 129X1/SvJ * CWD/LeAgl * SJL/J	MGI:5489761
ht3	Gja8^Lop10/Gja8^tm1Scr	involves: 129S4/SvJae * AKR/J * BALB/cJ * C57BL/6J	MGI:3848970
cx4	Gja3^tm1Scr/Gja3^tm1Scr Gja8^L1/Gja8^tm1Scr	involves: 129 * C3H/HeJ * C57BL/6J	MGI:3811922
cx5	Gja3^tm1Scr/Gja3^tm1Scr Gja8^tm1Scr/Gja8^tm1Scr	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	MGI:3811924

Allelic Composition	Gja8^L1/Gja8^tm1Scr
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja8^L1 mutation (1 available); any Gja8 mutation (33 available)
Gja8^tm1Scr mutation (0 available); any Gja8 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:108522 )

N	• lack cysts in lens

total cataract ( J:108522 )

• whole cataracts

microphthalmia ( J:108522 )

Allelic Composition	Gja8^R205G/Gja8^tm1Scr
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CWD/LeAgl * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja8^R205G mutation (1 available); any Gja8 mutation (33 available)
Gja8^tm1Scr mutation (0 available); any Gja8 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Microphthalmia and small lenses with dense nuclear cataracts in Gja8^R205G/Gja8^tm1Scr mice

vision/eye

nuclear cataract ( J:195727 )

• dense

microphthalmia ( J:195727 )

Allelic Composition	Gja8^Lop10/Gja8^tm1Scr
Genetic Background	involves: 129S4/SvJae * AKR/J * BALB/cJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja8^Lop10 mutation (1 available); any Gja8 mutation (33 available)
Gja8^tm1Scr mutation (0 available); any Gja8 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

cataract ( J:75387 )

• dense cataracts by 3 weeks of age

microphthalmia ( J:75387 )

Allelic Composition	Gja3^tm1Scr/Gja3^tm1Scr Gja8^L1/Gja8^tm1Scr
Genetic Background	involves: 129 * C3H/HeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja3^tm1Scr mutation (0 available); any Gja3 mutation (17 available)
Gja8^L1 mutation (1 available); any Gja8 mutation (33 available)
Gja8^tm1Scr mutation (0 available); any Gja8 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:108522 )

N	• normal lens fiber cell elongation

nuclear cataract ( J:108522 )

• large nuclear cataracts 3 weeks of age

microphthalmia ( J:108522 )

Allelic Composition	Gja3^tm1Scr/Gja3^tm1Scr Gja8^tm1Scr/Gja8^tm1Scr
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja3^tm1Scr mutation (0 available); any Gja3 mutation (17 available)
Gja8^tm1Scr mutation (0 available); any Gja8 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:108522 )

N	• normal lens fiber cell elongation

nuclear cataract ( J:108522 )

• large nuclear cataracts 3 weeks of age

microphthalmia ( J:108522 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24