All Phenotypes Rab23<opb2> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rab23^opb2
open brain 2
MGI:2137533

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rab23^opb2/Rab23^opb2	involves: C3HeB/FeJ * C57BL/6J	MGI:3580670
hm2	Rab23^opb2/Rab23^opb2	involves: C3H/HeJ * C57BL/6J	MGI:3721245
cx3	Cdk20^tm1.1Jegg/Cdk20^tm1.1Jegg Rab23^opb2/Rab23^opb2	involves: 129S7/SvEvBrd * C57BL/6J * FVB/N	MGI:6113531

Allelic Composition	Rab23^opb2/Rab23^opb2
Genetic Background	involves: C3HeB/FeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab23^opb2 mutation (0 available); any Rab23 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:98216 )

• die at E13-E14

limbs/digits/tail

polydactyly ( J:98216 )

nervous system

exencephaly ( J:98216 )

abnormal spinal cord morphology ( J:98216 )

• ventralized caudal spinal cord

Allelic Composition	Rab23^opb2/Rab23^opb2
Genetic Background	involves: C3H/HeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab23^opb2 mutation (0 available); any Rab23 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:48268 )

• most mice die between E12.5 and E14.5

nervous system

incomplete caudal neuropore closure ( J:48268 )

• at E10.5, mice exhibit a failure to close the posterior neural tube

exencephaly ( J:48268 )

vision/eye

abnormal eye morphology ( J:48268 )

• at E10.5, mice are missing one or both eyes or display eye abnormalities

limbs/digits/tail

polydactyly ( J:48268 )

• mice that survive at E13.5 have extra digits on all four limbs

embryo

incomplete caudal neuropore closure ( J:48268 )

• at E10.5, mice exhibit a failure to close the posterior neural tube

Allelic Composition	Cdk20^tm1.1Jegg/Cdk20^tm1.1Jegg Rab23^opb2/Rab23^opb2
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk20^tm1.1Jegg mutation (0 available); any Cdk20 mutation (10 available)
Rab23^opb2 mutation (0 available); any Rab23 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal neural tube morphology ( J:243907 )

• P3 interneuron progenitors flanking the floor plate are reduced in number

absent floor plate ( J:243907 )

• at E10.5

• similar to mice homozygous null for Cdk20 alone

nervous system

abnormal neural tube morphology ( J:243907 )

• P3 interneuron progenitors flanking the floor plate are reduced in number

absent floor plate ( J:243907 )

• at E10.5

• similar to mice homozygous null for Cdk20 alone

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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