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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Smobnb
bent body
MGI:2137553
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Smobnb/Smobnb involves: C3HeB/FeJ * C57BL/6J MGI:3580659
hm2
 		Smobnb/Smobnb involves: C3H/HeJ * C57BL/6J MGI:3721246
cx3
 		Smobnb/Smobnb
Tmem107schlei/Tmem107schlei 		involves: C3HeB/FeJ * C57BL/6J MGI:5433093
cx4
 		Ift172wim/Ift172wim
Smobnb/Smobnb 		involves: C57BL/6J MGI:3624270
cx5
 		Kif7maki/Kif7maki
Smobnb/Smobnb
Tg(Hlxb9-GFP)1Tmj/? 		involves: C57BL/6J * FVB/N MGI:4355987


Genotype
MGI:3580659
hm1
Allelic
Composition		 Smobnb/Smobnb
Genetic
Background		 involves: C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smobnb mutation (0 available); any Smo mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
abnormal left-right axis patterning ( J:98216 )
• left-right randomization

nervous system
abnormal spinal cord morphology ( J:98216 )
• dorsalized spinal cord




Genotype
MGI:3721246
hm2
Allelic
Composition		 Smobnb/Smobnb
Genetic
Background		 involves: C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smobnb mutation (0 available); any Smo mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal direction of embryo turning ( J:48268 )
• 13 of 25 mice initiate turning in the proper direction (to the right) while 12 of 25 mice start to turn in the opposite direction (to the left)
broad limb buds ( J:48268 )
• at E9.5, limb buds are disproportionally large

cardiovascular system
abnormal heart looping ( J:48268 )
• no clear looping to the left or right is observed
pericardial edema ( J:48268 )
• at E9.5
hemorrhage ( J:48268 )
• at E9.5, mice exhibit hemorrhages in the mesenchyme of the tail, limb buds and head

growth/size/body
decreased embryo size ( J:48268 )
• at E9.5

limbs/digits/tail
broad limb buds ( J:48268 )
• at E9.5, limb buds are disproportionally large

homeostasis/metabolism
pericardial edema ( J:48268 )
• at E9.5




Genotype
MGI:5433093
cx3
Allelic
Composition		 Smobnb/Smobnb
Tmem107schlei/Tmem107schlei
Genetic
Background		 involves: C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smobnb mutation (0 available); any Smo mutation (39 available)
Tmem107schlei mutation (0 available); any Tmem107 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal floor plate morphology ( J:186552 )
• absence of ventral cell types (V3) in the floor plate
• Background Sensitivity: however, ventral neuron specification defects observed in Smobnb homozygotes is partially rescued

embryo
abnormal floor plate morphology ( J:186552 )
• absence of ventral cell types (V3) in the floor plate
• Background Sensitivity: however, ventral neuron specification defects observed in Smobnb homozygotes is partially rescued




Genotype
MGI:3624270
cx4
Allelic
Composition		 Ift172wim/Ift172wim
Smobnb/Smobnb
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ift172wim mutation (0 available); any Ift172 mutation (75 available)
Smobnb mutation (0 available); any Smo mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:100466 )
• double mutants survive to E10.5-11.5

cardiovascular system
abnormal direction of heart looping ( J:100466 )
• mutants exhibit randomization of heart looping polarity

nervous system
open neural tube ( J:100466 )
• double mutants have an open neural tube at E10.5
decreased motor neuron number ( J:100466 )
• only a few motor neurons are detected in the spinal cords of mutants

embryo
open neural tube ( J:100466 )
• double mutants have an open neural tube at E10.5




Genotype
MGI:4355987
cx5
Allelic
Composition		 Kif7maki/Kif7maki
Smobnb/Smobnb
Tg(Hlxb9-GFP)1Tmj/?
Genetic
Background		 involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif7maki mutation (0 available); any Kif7 mutation (40 available)
Smobnb mutation (0 available); any Smo mutation (39 available)
Tg(Hlxb9-GFP)1Tmj mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:151965 )
• compound mutants develop until E10.5, unlike Smo single mutants that die at or before E9.0

nervous system
nervous system phenotype ( J:151965 )
N
• unlike Smo single mutants, compound mutants develop ventral neural types




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory