Phenotypes associated with this allele

• Allele Symbol: Ptger3^tm1Sna
• Allele Name: targeted mutation 1, Shuh Narumiya
• Allele ID: MGI:2137759
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptger3^tm1Sna/Ptger3^tm1Sna	B6.129P2-Ptger3^tm1Sna/Sna	MGI:3590538
hm2	Ptger3^tm1Sna/Ptger3^tm1Sna	involves: 129P2/OlaHsd	MGI:4415818
hm3	Ptger3^tm1Sna/Ptger3^tm1Sna	involves: 129P2/OlaHsd * C57BL/6	MGI:2175005
hm4	Ptger3^tm1Sna/Ptger3^tm1Sna	involves: 129P2/OlaHsd * C57BL/6J	MGI:4834184

Genotype
MGI:3590538

hm1

• Allelic Composition: Ptger3^tm1Sna/Ptger3^tm1Sna
• Genetic Background: B6.129P2-Ptger3^tm1Sna/Sna

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating adrenocorticotropin level ( J:82750 )

• homozygotes display impaired LPS-induced ACTH release, eliciting a peak of ACTH release at 2 hrs but failing to exhibit an increase at 3 hrs after LPS injection

• defective LPS-induced HPA axis activation is associated with defective LPS-induced Fos expression in PVN neurons, and occurs in the absence of obvious pituitary abnormalities

abnormal body temperature homeostasis ( J:105574 )

• turpentine injection induces only a hypothermic response

impaired febrile response ( J:105574 )

• the increase in temperature seen 20 minutes after exposure to 1 ug/kg LPS is blunted and later increases do not occur

• treatment with 10 ug/kg results in a blunted increase in temperature followed by a hypothermic response

• treatment with 100 ug/kg results in a blunted increase in temperature followed by a profound hypothermic response

• treatment with 1 mg/kg produces a more intense triphasic hypothermia rather than the biphasic hypothermic response seen in wild-type controls

edema ( J:197334 )

• in a model of IgE antigen-dependent passive cutaneous anaphylaxis, mice exhibit slightly increased dye extravasation (a measure of edema) compared with wild-type mice

abnormal physiological response to xenobiotic ( J:105574 )

• turpentine injection induces only a hypothermic response

immune system

increased susceptibility to type I hypersensitivity reaction ( J:197334 )

• in a model of IgE antigen-dependent passive cutaneous anaphylaxis, mice exhibit slightly increased dye extravasation (a measure of edema) compared with wild-type mice

abnormal response to infection ( J:82750 )

• homozygotes display impaired LPS-induced ACTH release, eliciting a peak of ACTH release at 2 hrs but failing to exhibit an increase at 3 hrs after LPS injection

Genotype
MGI:4415818

hm2

• Allelic Composition: Ptger3^tm1Sna/Ptger3^tm1Sna
• Genetic Background: involves: 129P2/OlaHsd

homeostasis/metabolism

impaired febrile response ( J:155398 )

• mice injected RANKL (Tnfsf11) fail to develop a fever response unlike similarly treated wild-type mice

abnormal response/metabolism to endogenous compounds ( J:155398 )

• mice injected RANKL (Tnfsf11) fail to develop a fever response or alterations in circadian activity unlike similarly treated wild-type mice

behavior/neurological

behavior/neurological phenotype ( J:115400 )

N • similar to wild-type controls and unlike mice null for Ptger1 treatment with 500 ng/kg of PGE2 induces mechanical allodynia

abnormal pain threshold ( J:115400 )

• PGE2 induces a monophasic hyperalgesic response over a narrower range of dosages compared to wild-type controls

Genotype
MGI:2175005

hm3

• Allelic Composition: Ptger3^tm1Sna/Ptger3^tm1Sna
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

mortality/aging

mortality/aging ( J:70534 )

N • homozygotes are fertile, grow normally, live longer than 1 year, and display no overt morphological abnormalities

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:103150 )

N • unlike in mice null for Ptger1, gastric mucosal responses to taurocholate are similar to controls

impaired febrile response ( J:70534 )

• homozygotes fail to exhibit a febrile response to PGE2 and to either IL-1beta or LPS

Genotype
MGI:4834184

hm4

• Allelic Composition: Ptger3^tm1Sna/Ptger3^tm1Sna
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:59509 )

N • no difference in the number of aberrant crypt foci induced by azoxymethane compared to wild-type controls