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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ptger1tm1Sna
targeted mutation 1, Shuh Narumiya
MGI:2137762
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ptger1tm1Sna/Ptger1tm1Sna B6CrSlc.129P2-Ptger1tm1Sna/Sna MGI:4834182
hm2
Ptger1tm1Sna/Ptger1tm1Sna involves: 129P2/OlaHsd MGI:4834180
hm3
Ptger1tm1Sna/Ptger1tm1Sna involves: 129P2/OlaHsd * C57BL/6 MGI:2175004
hm4
Ptger1tm1Sna/Ptger1tm1Sna involves: 129P2/OlaHsd * C57BL/6Cr MGI:4834183
hm5
Ptger1tm1Sna/Ptger1tm1Sna involves: 129P2/OlaHsd * C57BL/6J MGI:4834179


Genotype
MGI:4834182
hm1
Allelic
Composition
Ptger1tm1Sna/Ptger1tm1Sna
Genetic
Background
B6CrSlc.129P2-Ptger1tm1Sna/Sna
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptger1tm1Sna mutation (1 available); any Ptger1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
(J:128435)
• in a model of IgE antigen-dependent passive cutaneous anaphylaxis, mice exhibit normal dye extravasation (a measure of edema) (J:197334)
• in DNFB sensitized mice the number of T-bet expressing cells in the draining lymph nodes is significantly reduced
• results indicate a defect in Tc1 cell differentiation in DFNB sensitized mice
• in DNFB sensitized mice the number of T-bet expressing cells in the draining lymph nodes is significantly reduced
• after DNFB challenge during the elicitation phase cervical lymph nodes show a decrease in the total cell number and in the numbers of IFNG producing cells in the CD8+ and CD4+ cell populations
• in sensitized mice ear swelling following application of 0.3% dinitrofluorobenzene (DNFB) is significantly attenuated compared to wild-type controls
• cultured lymph node cells from sensitized mice show a decreased production of IFNG following dinitrobenzene sulfonic acid (DNBS) challenge
• however, when immunized with a high dose of DNFB (1% vs 0.5%) ear swelling is similar to wild-type controls
• cultured lymph node cells from sensitized mice show a decreased production of IFNG following dinitrobenzene sulfonic acid (DNBS) challenge
• the increase in adrenocorticotropic hormone induced by LPS in wild-type mice is absent in nulls at 1 h after treatment

behavior/neurological
N
• no differences are detected in anxiety related behavior in a light/dark box assay or an elevated plus maze assay
• males introduced to a younger conspecific male in a neutral cage display an increase in the frequency of aggressive encounters
• males treated with LPS display extensive aggression with little social contact, aggression is as frequent in LPS treated and saline treated mice
• decrease in the latency to onset of fighting and increase in the number of fights in an electric shock induced fighting assay
• however, no difference in sensitivity to electric shock is detected
• antagonists to either dopamine 1 or dopamine 2 receptors restore the latency to first fight and number and duration fights to wild-type levels in an electric shock induced fighting assay
• in a cliff avoidance test 7 of 7 mice jump off the transparent platform
• mice display behavioral disinhibition under stress in multiple assays
• display exaggerated response to stimuli throughout the dynamic range of audible sound frequencies
• in an open field the incidence of rearing is reduced and the incidence of spontaneous jumping is increased
• males spend less time sniffing a novel younger conspecific male when introduced in a neutral cage

homeostasis/metabolism
• the increase in adrenocorticotropic hormone induced by LPS in wild-type mice is absent in nulls at 1 h after treatment
• the early rise in temperature induced by exposure to 10 ug/kg is blunted
• treatment with 100 ug/kg LPS fails to increase the body temperature
• following treatment with 1 mg/kg the first phase of hypothermia is absent but the second phase is similar to wild-type controls
• a decrease in dopamine concentration and an increase in the concentration of dopamine metabolites is detected in the frontal cortex and striatum
• increase in extracellular dopamine in the dorsal striatum
• however, no abnormalities in dopamine reuptake, degradation or release are detected

hematopoietic system
• in DNFB sensitized mice the number of T-bet expressing cells in the draining lymph nodes is significantly reduced
• results indicate a defect in Tc1 cell differentiation in DFNB sensitized mice




Genotype
MGI:4834180
hm2
Allelic
Composition
Ptger1tm1Sna/Ptger1tm1Sna
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptger1tm1Sna mutation (1 available); any Ptger1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• unlike in wild-type mice treatment with 500 ng/kg of PGE2 fails to induce mechanical allodynia
• hyperalgesia is seen in both PGE2 and saline injected mice




Genotype
MGI:2175004
hm3
Allelic
Composition
Ptger1tm1Sna/Ptger1tm1Sna
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptger1tm1Sna mutation (1 available); any Ptger1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• homozygotes are fertile, grow normally, live longer than 1 year and display no overt morphological abnormalities

homeostasis/metabolism
N
• homozygotes exhibit a normal febrile response to PGE2 and to either IL-1-beta or LPS relative to wild-type mice
• the gastric hyperaemic response to taurocholate is blocked
• the time to recovery of baseline gastric potential difference after exposure to taurocholate is increased
• however, the decrease in potential difference induced by taurocholate is similar to controls
• treatment with taurocholate plus acid induces severe lesions in the gastric mucosa with a lesion score 3.2 times higher than in wild-type littermate controls




Genotype
MGI:4834183
hm4
Allelic
Composition
Ptger1tm1Sna/Ptger1tm1Sna
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6Cr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptger1tm1Sna mutation (1 available); any Ptger1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• following azoxymethane exposure the incidence of colon tumors is decreased
• following azoxymethane exposure the colon tumor volume is decreased
• in azoxymethane induced colon tumors cell proliferation is decreased and apoptosis is increased

homeostasis/metabolism
• body weights are significantly greater at 35 and 50 weeks after azoxymethane exposure
• following azoxymethane exposure the incidence of colon tumors is decreased

growth/size/body
• body weights are significantly greater at 35 and 50 weeks after azoxymethane exposure




Genotype
MGI:4834179
hm5
Allelic
Composition
Ptger1tm1Sna/Ptger1tm1Sna
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptger1tm1Sna mutation (1 available); any Ptger1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• decrease in the number of aberrant crypt foci induced by azoxymethane compared to wild-type controls





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory