All Phenotypes Apoe<tm1Bres> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Apoe^tm1Bres
targeted mutation 1, Jan L Breslow
MGI:2137814

Summary

20 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Apoe^tm1Bres/Apoe^tm1Bres	B6.129P2-Apoe^tm1Bres	MGI:4437891
hm2	Apoe^tm1Bres/Apoe^tm1Bres	either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)	MGI:2174912
hm3	Apoe^tm1Bres/Apoe^tm1Bres	involves: 129P2/OlaHsd * C57BL/6	MGI:3834756
hm4	Apoe^tm1Bres/Apoe^tm1Bres	involves: 129P2/OlaHsd * C57BL/6 * NIH Black Swiss	MGI:3690368
ht5	Apoe^tm1Bres/Apoe⁺	either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)	MGI:2174913
cn6	Apoe^tm1Bres/Apoe^tm1Bres Bcl2^tm1Irt/Bcl2^tm1Irt Lyz2^tm1(cre)Ifo/Lyz2⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:3830965
cx7	Apoe^tm1Bres/Apoe^tm1Bres Esr1^tm1Ksk/Esr1^tm1Ksk	B6.129P2-Apoe^tm1Bres Esr1^tm1Ksk	MGI:4437892
cx8	Apoe^tm1Bres/Apoe^tm1Bres Cd59a^tm1Bpm/Cd59a^tm1Bpm	involves: 129 * 129P2/OlaHsd	MGI:5298859
cx9	Apoe^tm1Bres/Apoe^tm1Bres Plau^tm1Mlg/Plau^tm1Mlg	involves: 129 * C57BL/6	MGI:3527476
cx10	Apoe^tm1Bres/Apoe^tm1Bres C6^Q0/C6^Q0	involves: 129P2/OlaHsd	MGI:5298860
cx11	Apoe^tm1Bres/Apoe^tm1Bres Mapk8^tm1Flv/Mapk8^tm1Flv	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6	MGI:3691112
cx12	Apoe^tm1Bres/Apoe^tm1Bres Mapk9^tm1Flv/Mapk9^tm1Flv	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:3691097
cx13	Apoa2^tm1Bres/Apoa2⁺ Apoe^tm1Bres/Apoe^tm1Bres	involves: 129P2/OlaHsd * 129S4/SvJae	MGI:2655399
cx14	Apoa2^tm1Bres/Apoa2^tm1Bres Apoe^tm1Bres/Apoe^tm1Bres	involves: 129P2/OlaHsd * 129S4/SvJae	MGI:2655397
cx15	Apoe^tm1Bres/Apoe^tm1Bres Cx3cr1^tm1Ifc/Cx3cr1^tm1Ifc	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	MGI:2450893
cx16	Apoe^tm1Bres/Apoe^tm1Bres Ltb4r1^tm1Adl/Ltb4r1^tm1Adl	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	MGI:3811013
cx17	Apoe^tm1Bres/Apoe^tm1Bres Ifngr1^tm1Agt/Ifngr1^tm1Agt	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J	MGI:4838232
cx18	Apoc1^tm2Lmh/Apoc1^tm2Lmh Apoe^tm1Bres/Apoe^tm1Bres	involves: 129P2/OlaHsd * C57BL/6	MGI:3697329
cx19	Apoe^tm1Bres/Apoe^tm1Bres Plg^tm1Jld/Plg^tm1Jld	involves: 129P2/OlaHsd * C57BL/6 * NIH Black Swiss	MGI:3690365
cx20	Apoe^tm1Bres/Apoe^tm1Bres Fn1^tm1Bwg/Fn1^tm1Bwg	involves: 129S4/SvJae * C57BL/6	MGI:3046828

Allelic Composition	Apoe^tm1Bres/Apoe^tm1Bres
Genetic Background	B6.129P2-Apoe^tm1Bres

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Bres mutation (9 available); any Apoe mutation (158 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

atherosclerotic lesions ( J:68574 )

• treatment of ovariectomized females with estradiol inhibits lesion progression

homeostasis/metabolism

abnormal circulating cholesterol level ( J:68574 )

• in ovariectomized females exogenous estradiol treatment reduces fasting plasma cholesterol

xanthoma ( J:68574 )

• ovariectomized females not treated with estradiol display subcutaneous infiltration of lipid laden macrophages

Allelic Composition	Apoe^tm1Bres/Apoe^tm1Bres
Genetic Background	either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Bres mutation (9 available); any Apoe mutation (158 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

increased susceptibility to atherosclerosis ( J:2809 )

• on a normal chow diet 3 out of 3 homozygotes developed lesions (mean area 3157 +/- 437 um²) compared to 0 out of 12 wild-type mice

• on a high fat high cholesterol diet all 9 homozygotes developed large lesions in the proximal aorta (mean area 9230 +/- 4700 um²) while no wild-type mice on the same diet developed lesions

• on a high fat high cholesterol diet lesions were found in the proximal aorta, and the coronary and pulmonary arteries

digestive/alimentary system

abnormal digestive system physiology ( J:2809 )

• in a vitamin A-fat tolerance test postprandial retinyl ester levels are very high by 4 hours and show no signs of decrease by 12 hours unlike in wild-type mice where retinyl ester levels return to baseline by 12 hours suggesting severely impaired clearance of dietary fat

homeostasis/metabolism

abnormal circulating LDL cholesterol level ( J:2809 )

• much of the cholesterol increase is in the VLDL + IDL and LDL fractions

• the LDL fraction is increased to 100 +/- 22 mg/dl compared to 7 +/- 3 mg/dl in wild-type mice

• on a high fat high cholesterol diet the LDL fraction is increased to 143 +/- 65 mg/dl compared to 16 +/- 15 mg/dl in wild-type mice

increased circulating cholesterol level ( J:2809 , J:42426 )

• on a normal chow diet total plasma cholesterol is 494 +/- 95 mg/dl compared to 60 +/- 20 mg/dl in wild-type mice (J:2809)

• on a high fat high cholesterol diet total plasma cholesterol is 1821 +/- 395 mg/dl compared to 132 +/- 18 mg/dl in wild-type mice (J:2809)

• total plasma cholesterol is 501 +/- 40 compared to 98 +/- 5 mg/dl in wild-type mice (J:42426)

• however, total plasma cholesterol levels were not significantly elevated in heterozygous mice (101 +/- 10 mg/dl) (J:42426)

increased circulating VLDL cholesterol level ( J:2809 )

• much of the cholesterol increase is in the VLDL + IDL and LDL fractions

• the VLDL + IDL fraction is increased to 373 +/- 105 mg/dl compared to 21 +/- 6 mg/dl in wild-type mice

• on a high fat high cholesterol diet the VLDL + IDL fraction is increased to 1565 +/- 474 mg/dl compared to 50 +/- 14 mg/dl in wild-type mice

increased triglyceride level ( J:2809 )

• triglyceride levels are increased compared to wild-type mice on either a normal or high fat high cholesterol diet

nervous system

abnormal hippocampus morphology ( J:42426 )

• dendritic simplification is more prominent in the CA1-CA2 pyramidal cell layer and in the molecular layer

abnormal cerebral cortex morphology ( J:42426 )

• at 4 months of age widespread vacuolization of apical dendrites and tortuous, dilated, and irregular dendrites are seen

• occasionally, the presynaptic terminals around the dendrites are distended

• this phenotype is mild at 4 months of age but becomes more severe with age

• malformations are more prominent in layers 2, 3, and 5 of the front-parietal region

• in 8 month old mutants a 30% loss of synapses is seen

abnormal neuron morphology ( J:42426 )

• in 12 month old mutants, neurons in the fronto-parietal and hippocampal regions prominently display fragmentation and disruption of the neuritic processes

• neurons in the frontal cortex of 8 month old mutants have disarrayed microtubules, fragmented dendrites, and a distended and vacuolized endomembrane system and spinal apparatus

Allelic Composition	Apoe^tm1Bres/Apoe^tm1Bres
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Bres mutation (9 available); any Apoe mutation (158 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

atherosclerotic lesions ( J:29950 )

• mice fed a cholate-free diet containing 0.15% cholesterol for 6 months develop extensive lesions throughout the aorta; the extent of atherosclerosis in the entire aorta correlates with the size of lesions in the aortic origin

• a trend towards more lesions in males than females is observed

increased susceptibility to atherosclerosis ( J:43846 )

• on a high fat, high cholesterol diet, mutants exhibit moderate to severe aortic and carotid atherosclerosis

homeostasis/metabolism

increased circulating cholesterol level ( J:29950 )

• mice fed a cholate-free diet containing 0.15% cholesterol exhibit increased average total plasma cholesterol levels

xanthoma ( J:43846 )

• 4 of 4 aged mice (15-23 months) kept on a high fat, high cholesterol diet from 17 weeks of age develop cerebral xanthoma, consisting of crystalline cholesterol clefts, lipid globules and foam cells

• 2 of 9 mice on a normal diet develop small choroid plexus xanthomas

Allelic Composition	Apoe^tm1Bres/Apoe^tm1Bres
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * NIH Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Bres mutation (9 available); any Apoe mutation (158 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Gross appearance of aortic arches of Apoe^tm1Bres/Apoe^tm1Bres, Plg^tm1Jld/Plg^tm1Jld and Apoe^tm1Bres/Apoe^tm1Bres Plg^tm1Jld/Plg^tm1Jld mice

cardiovascular system

atherosclerotic lesions ( J:42927 )

• 57 of 63 display aortic lesion at 18 to 25 weeks of age

• lesions contain fibrinogen deposits

homeostasis/metabolism

decreased circulating HDL cholesterol level ( J:42927 )

• small decrease in high density lipoprotein cholesterol

increased circulating cholesterol level ( J:42927 )

increased circulating triglyceride level ( J:42927 )

Allelic Composition	Apoe^tm1Bres/Apoe⁺
Genetic Background	either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Bres mutation (9 available); any Apoe mutation (158 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal digestive system physiology ( J:2809 )

• a vitamin A-fat tolerance test suggests a mild defect in dietary fat clearance

homeostasis/metabolism

increased circulating cholesterol level ( J:2809 )

• total cholesterol is slightly but significantly elevated to 81 +/- 18 mg/dl compared to 60 +/- 20 mg/dl in wild-type mice

• on a high fat high cholesterol diet total cholesterol is not significantly different from wild-type mice

Allelic Composition	Apoe^tm1Bres/Apoe^tm1Bres Bcl2^tm1Irt/Bcl2^tm1Irt Lyz2^tm1(cre)Ifo/Lyz2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Bres mutation (9 available); any Apoe mutation (158 available)
Bcl2^tm1Irt mutation (1 available); any Bcl2 mutation (41 available)
Lyz2^tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased macrophage apoptosis ( J:144243 )

• a higher level of intimal cell (macrophage) apoptosis is observed in atherosclerotic lesions relative to controls after receiving a Western diet for 10 weeks

cardiovascular system

cardiovascular system phenotype ( J:144243 )

N	• after 4 weeks on a Western diet, mice have similar lesion areas in proximal aortas and no or very rarely detected macrophage apoptosis in the lesions, very similar to pathology observed in controls

atherosclerotic lesions ( J:144243 )

• 8 week-old mice fed a Western diet for 4 weeks display proximal aorta lesions similar to control animals

• necrotic areas observed in lesions are larger than observed in controls after receiving a Western diet for 10 weeks

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:144243 )

N	• mice show similar weights and levels of plasma lipoproteins to controls after 4 weeks on a Western diet

cellular

increased macrophage apoptosis ( J:144243 )

• a higher level of intimal cell (macrophage) apoptosis is observed in atherosclerotic lesions relative to controls after receiving a Western diet for 10 weeks

hematopoietic system

increased macrophage apoptosis ( J:144243 )

• a higher level of intimal cell (macrophage) apoptosis is observed in atherosclerotic lesions relative to controls after receiving a Western diet for 10 weeks

Allelic Composition	Apoe^tm1Bres/Apoe^tm1Bres Esr1^tm1Ksk/Esr1^tm1Ksk
Genetic Background	B6.129P2-Apoe^tm1Bres Esr1^tm1Ksk

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Bres mutation (9 available); any Apoe mutation (158 available)
Esr1^tm1Ksk mutation (2 available); any Esr1 mutation (68 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

atherosclerotic lesions ( J:68574 )

increased susceptibility to atherosclerosis ( J:68574 )

• in ovariectomized females the ability of treatment with estradiol to inhibit lesion progression is impaired

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:68574 )

N	• unlike ovariectomized wild-type for Esr1, xanthoma formation is rarely seen

abnormal circulating cholesterol level ( J:68574 )

• in ovariectomized females exogenous estradiol treatment fails to reduce fasting plasma cholesterol

reproductive system

uterus atrophy ( J:68574 )

• in ovariectomized females implanted with estradiol

Allelic Composition	Apoe^tm1Bres/Apoe^tm1Bres Cd59a^tm1Bpm/Cd59a^tm1Bpm
Genetic Background	involves: 129 * 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Bres mutation (9 available); any Apoe mutation (158 available)
Cd59a^tm1Bpm mutation (0 available); any Cd59a mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

increased susceptibility to atherosclerosis ( J:158457 )

• mice fed a high-fat diet exhibit increased atherosclerotic plaque formation, decreased deposition of membrane attack complex, increased smooth muscle cells in early plaques, and decreased smooth muscle cells in advanced plaques compared with Apoe^tm1Bres homozygotes

vascular smooth muscle hyperplasia ( J:158457 )

• in advanced plaques of mice fed a high-fat diet

vascular smooth muscle hypoplasia ( J:158457 )

• in early plaques of mice fed a high-fat diet

muscle

vascular smooth muscle hyperplasia ( J:158457 )

• in advanced plaques of mice fed a high-fat diet

vascular smooth muscle hypoplasia ( J:158457 )

• in early plaques of mice fed a high-fat diet

Allelic Composition	Apoe^tm1Bres/Apoe^tm1Bres Plau^tm1Mlg/Plau^tm1Mlg
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Bres mutation (9 available); any Apoe mutation (158 available)
Plau^tm1Mlg mutation (3 available); any Plau mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased susceptibility to atherosclerosis ( J:44387 )

• at >15 weeks of age, double homozygotes fed an atherogenic diet show only minimal destruction of the atherosclerotic aorta wall relative to Apoe^tm1Bres mice

• in double mutants, the media remain largely intact with continuous elastic membranes and multiple smooth-muscle cell layers; no infiltrating macrophages are detected, except at the base of the intimal plaque

• double mutants show no atherosclerotic aneurysmal dilation or rupture whereas Apoe^tm1Bres mice exhibit a >50% dilation in the diameter of the abdominal aorta

aortic elastic tissue lesions ( J:44387 )

• at >15 weeks of age, double homozygotes fed an atherogenic diet display minimal fragmentation of the internal elastic membranes (EMs) in 10% of plaques; in contrast, Apoe^tm1Bres mice show fragmentation of EMs in 51% of plaques, and perforating transmedial ulceration in 21% of plaques

Allelic Composition	Apoe^tm1Bres/Apoe^tm1Bres C6^Q0/C6^Q0
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Bres mutation (9 available); any Apoe mutation (158 available)
C6^Q0 mutation (1 available); any C6 mutation (57 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased susceptibility to atherosclerosis ( J:158457 )

• mice fed a high-fat diet exhibit decreased atherosclerotic plaque formation and total vessel area affected compared with Apoe^tm1Bres homozygotes

Allelic Composition	Apoe^tm1Bres/Apoe^tm1Bres Mapk8^tm1Flv/Mapk8^tm1Flv
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Bres mutation (9 available); any Apoe mutation (158 available)
Mapk8^tm1Flv mutation (3 available); any Mapk8 mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

atherosclerotic lesions ( J:94044 )

• develop atherosclerosis similar to that seen in single Apoe homozygotes on a high-cholesterol diet for 14 weeks

Allelic Composition	Apoe^tm1Bres/Apoe^tm1Bres Mapk9^tm1Flv/Mapk9^tm1Flv
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Bres mutation (9 available); any Apoe mutation (158 available)
Mapk9^tm1Flv mutation (2 available); any Mapk9 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased susceptibility to atherosclerosis ( J:94044 )

• develop less atherosclerosis than single Apoe homozygotes when fed a high-cholesterol diet for 14 weeks

immune system

abnormal macrophage morphology ( J:94044 )

• isolated macrophages form filopodia-like projections in culture that are not observed in controls

increased macrophage derived foam cell number ( J:94044 )

• isolated peritoneal macrophages subjected to oxidized forms of low-density lipoproteins form only half as many foam cells as controls

abnormal macrophage physiology ( J:94044 )

• isolated peritoneal macrophages subjected to oxidized forms of low-density lipoproteins form only half as many foam cells as controls

• uptake and degradation of acetylated forms of low-density lipoproteins by macrophages is about one third that of controls

• cellular cholesterol efflux to apolipoprotein AI is increased in macrophages

hematopoietic system

abnormal macrophage morphology ( J:94044 )

• isolated macrophages form filopodia-like projections in culture that are not observed in controls

increased macrophage derived foam cell number ( J:94044 )

• isolated peritoneal macrophages subjected to oxidized forms of low-density lipoproteins form only half as many foam cells as controls

abnormal macrophage physiology ( J:94044 )

• isolated peritoneal macrophages subjected to oxidized forms of low-density lipoproteins form only half as many foam cells as controls

• uptake and degradation of acetylated forms of low-density lipoproteins by macrophages is about one third that of controls

• cellular cholesterol efflux to apolipoprotein AI is increased in macrophages

cellular

increased macrophage derived foam cell number ( J:94044 )

• isolated peritoneal macrophages subjected to oxidized forms of low-density lipoproteins form only half as many foam cells as controls

Allelic Composition	Apoa2^tm1Bres/Apoa2⁺ Apoe^tm1Bres/Apoe^tm1Bres
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoa2^tm1Bres mutation (5 available); any Apoa2 mutation (20 available)
Apoe^tm1Bres mutation (9 available); any Apoe mutation (158 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating cholesterol level ( J:37250 )

• 34% decrease in cholesterol levels compared to single Apoe homozygotes

Allelic Composition	Apoa2^tm1Bres/Apoa2^tm1Bres Apoe^tm1Bres/Apoe^tm1Bres
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating cholesterol level ( J:37250 )

• 66% decrease in cholesterol levels compared to single Apoe homozygotes

decreased circulating HDL cholesterol level ( J:37250 )

Allelic Composition	Apoe^tm1Bres/Apoe^tm1Bres Cx3cr1^tm1Ifc/Cx3cr1^tm1Ifc
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Bres mutation (9 available); any Apoe mutation (158 available)
Cx3cr1^tm1Ifc mutation (0 available); any Cx3cr1 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased susceptibility to atherosclerosis ( J:81822 )

• on a Western-type high-fat diet, double homozygotes show significant reductions in aortic atherosclerotic lesion area and thickness relative to single Apoe ^tm1Bres homozygotes (43%, 49%, and 36% at 5, 10, and 15 weeks, respectively)

• notably, double homozygotes exhibit retarded lesion development in both the aortic arch and thoracic/abdominal sections of the aorta; however, this difference is less pronounced in the arch

immune system

impaired macrophage chemotaxis ( J:81822 )

• after 10 weeks on a Western-type high-fat diet, double homozygotes exhibit a 40% reduction in macrophage infiltration of the aortic sinus relative to single Apoe^tm1Bres homozygotes

cellular

impaired macrophage chemotaxis ( J:81822 )

• after 10 weeks on a Western-type high-fat diet, double homozygotes exhibit a 40% reduction in macrophage infiltration of the aortic sinus relative to single Apoe^tm1Bres homozygotes

hematopoietic system

impaired macrophage chemotaxis ( J:81822 )

• after 10 weeks on a Western-type high-fat diet, double homozygotes exhibit a 40% reduction in macrophage infiltration of the aortic sinus relative to single Apoe^tm1Bres homozygotes

Allelic Composition	Apoe^tm1Bres/Apoe^tm1Bres Ltb4r1^tm1Adl/Ltb4r1^tm1Adl
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Bres mutation (9 available); any Apoe mutation (158 available)
Ltb4r1^tm1Adl mutation (1 available); any Ltb4r1 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased susceptibility to atherosclerosis ( J:117166 )

• mice exhibit a 55% reduced plaque burden compared to in Apoe^tm1Bres homozygotes

• when fed a Western diet, mice exhibit reduced plaque development, intimal area, and monocyte and T cell accumulation compared to in Apoe^tm1Bres homozygotes

• when fed a western diet, mice exhibit a 42.6% reduction in smooth muscle cells in the media and fibromuscular caps of lesions compared to in Apoe^tm1Bres homozygotes

Allelic Composition	Apoe^tm1Bres/Apoe^tm1Bres Ifngr1^tm1Agt/Ifngr1^tm1Agt
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Bres mutation (9 available); any Apoe mutation (158 available)
Ifngr1^tm1Agt mutation (13 available); any Ifngr1 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating cholesterol level ( J:40921 )

• compared to in Apoe^tm1Bres homozygotes

increased circulating phospholipid level ( J:40921 )

• compared to in Apoe^tm1Bres homozygotes

abnormal apolipoprotein level ( J:40921 )

• whether fed standard chow or a Western type diet, mice exhibit an increase in apoA-I levels compared to in wild-type mice

cardiovascular system

decreased susceptibility to atherosclerosis ( J:40921 )

• with smaller lesions, reduced lesion lipid content, and decreased lesion cellularity compared to in Apoe^tm1Bres homozygotes

Allelic Composition	Apoc1^tm2Lmh/Apoc1^tm2Lmh Apoe^tm1Bres/Apoe^tm1Bres
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoc1^tm2Lmh mutation (0 available); any Apoc1 mutation (11 available)
Apoe^tm1Bres mutation (9 available); any Apoe mutation (158 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal cholesterol homeostasis ( J:28261 )

• in controls, main cholesterol carrier is HDL and only ~10% is contained in the VLDL/LDL-sized fraction, while in mutants, most of the cholesterol (71%) is found in VLDL/LDL-sized fractions

increased circulating cholesterol level ( J:28261 )

• on a normal chow diet, mice are severely hypercholesterolemic compared to controls (12.5 mM vs 2.9 mM in controls)

• on mild high-fat/cholesterol (HFC) diet with 15% fat/0.25% cholesterol, serum cholesterol is increased 8-fold (to 31mM from 3.8 mM) with most of the increase found in VLDL/LDL-sized fractions

Allelic Composition	Apoe^tm1Bres/Apoe^tm1Bres Plg^tm1Jld/Plg^tm1Jld
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * NIH Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Bres mutation (9 available); any Apoe mutation (158 available)
Plg^tm1Jld mutation (2 available); any Plg mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Gross appearance of aortic arches of Apoe^tm1Bres/Apoe^tm1Bres, Plg^tm1Jld/Plg^tm1Jld and Apoe^tm1Bres/Apoe^tm1Bres Plg^tm1Jld/Plg^tm1Jld mice

mortality/aging

premature death ( J:42927 )

• only about 50% survive beyond 20 weeks of age

growth/size/body

abnormal body weight ( J:42927 )

• exhibit a larger decrease in body weight after 2 months of age than single Plg homozygotes

cardiovascular system

atherosclerotic lesions ( J:42927 )

• exhibit accelerated formation of and more extensive intimal lesions compared to single homozygous Apoe mutants

• lesions contain fibrinogen deposits

homeostasis/metabolism

decreased circulating HDL cholesterol level ( J:42927 )

• small reduction in HDL cholesterol

Allelic Composition	Apoe^tm1Bres/Apoe^tm1Bres Fn1^tm1Bwg/Fn1^tm1Bwg
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Bres mutation (9 available); any Apoe mutation (158 available)
Fn1^tm1Bwg mutation (1 available); any Fn1 mutation (130 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased susceptibility to atherosclerosis ( J:90917 )

• on a high fat high cholesterol diet double homozygous mutants have reduced lesion area compared to Apoe^tm1Bres homozygotes

homeostasis/metabolism

abnormal cholesterol homeostasis ( J:90917 )

• the cholesterol content of foam cells increases less in response to acetylated LDL compared to Apoe^tm1Bres homozygotes

decreased circulating VLDL cholesterol level ( J:90917 )

• fasting VLDL cholesterol levels after maintenance on a high fat diet are decreased compared to Apoe^tm1Bres homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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