immune system
N |
• in a model of IgE antigen-dependent passive cutaneous anaphylaxis, mice exhibit normal dye extravasation (a measure of edema)
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Allele Symbol Allele Name Allele ID |
Ptgirtm1Sna targeted mutation 1, Shuh Narumiya MGI:2137832 |
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Summary |
4 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• in a model of IgE antigen-dependent passive cutaneous anaphylaxis, mice exhibit normal dye extravasation (a measure of edema)
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|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• homozygotes that survive to birth grow normally, are fertile and live >1 year in the absence of overt abnormalities
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• breeding of heterozygotes produces homozygotes at a lower frequency than the predicted Mendelian ratio, suggesting embryonic loss esp. in males
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• homozygotes fail to exhibit prolonged bleeding times in response to beraprost (a prostacyclin mimetic), unlike wild-type mice
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• in response to catheter-induced carotid vascular injury, homozygotes display enhanced platelet activation, as shown by an increased injury-related increment in urinary excretion of metabolite 2,3-dinor-TxB2
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• homozygotes do not develop spontaneous thrombosis but exhibit increased susceptibility to arterial thrombosis induced by FeCl3
(J:42275)
• at 4 hrs after FeCl3 exposure, ~2/3 of mutant arteries exhibit obstructive thrombi with reddish tails, whereas wild-type preparations display mural thrombi of yellowish color
(J:42275)
• after prolonged FeCl3 treatment, 30% of homozygotes die within 1 day due to bilateral occlusions of the carotid arteries and/or embolic stroke, whereas all wild-type mice survive treatment
(J:42275)
• carotid artery occlusion time after photochemical injury is shortened
(J:108957)
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• homozygotes show a normal prostacyclin concentration in the peritoneal lavage fluid after dilute acetic acid treatment; in contrast, PGE2 levels are reduced to ~25% of prostacyclin levels
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• after catheter-induced carotid vascular injury, homozygotes show an increased periprocedural increment in urinary metabolite 2,3-dinor-TxB2
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• in the carrageenin-induced paw-edema model, homozygotes exhibit reduced edema formation similar to that observed in indomethacin-pretreated wild-type mice
• in addition, homozygotes display a marked reduction of exudate volume in the carrageenin-induced pleurisy model
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• in the acetic acid-induced writhing test, homozygotes exhibit reduced nociceptive perception to levels noted in indomethacin-pretreated wild-type mice
• notably, prostacyclin induces a writhing response in 60% of wild-type mice and in 0% of mutant mice, whereas PGE2 induces a response in less than 25% of animals in both genotypes
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N |
• under basal conditions, homozygotes are normotensive and exhibit a normal heart rate and normal bleeding times relative to wild-type mice
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• in response to catheter-induced carotid vascular injury, homozygotes exhibit an increased % of luminal stenosis relative to wild-type mice
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• in response to catheter-induced carotid vascular injury, homozygotes exhibit enhanced vascular proliferative indices, as shown by a significant increase in the intima-to-media ratio, % of luminal stenosis, and the number of intimal and medial BrdU-labeled cells relative to wild-type mice
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• in response to catheter-induced carotid vascular injury, homozygotes display enhanced platelet activation, as shown by an increased injury-related increment in urinary excretion of metabolite 2,3-dinor-TxB2
|
|
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• ACF formation in the distal colon is associated with a slight increase in spleen weight
• 9-week-old males treated with colon carcinogen azoxymethane exhibit no significant differences in the numbers of aberrant crypt (AC) foci per colon or ACs per focus relative to wild-type counterparts
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• following catheter-induced carotid vascular injury, double homozygotes fail to exhibit the enhanced vascular proliferative response observed in Ptgirtm1Sna homozygotes
• in double homozygotes, the intima-to-media ratio, % of luminal stenosis, and the number of BrdU-labeled cells is comparable to observed in wild-type mice; in addition, the periprocedural increment in platelet activation noted in Ptgirtm1Sna homozygotes is abolished
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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