Phenotypes associated with this allele

• Allele Symbol: Apcs^tm1Mpe
• Allele Name: targeted mutation 1, Mark B Pepys
• Allele ID: MGI:2138028
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Apcs^tm1Mpe/Apcs^tm1Mpe	129.Cg-Apcs^tm1Mpe	MGI:3775457
hm2	Apcs^tm1Mpe/Apcs^tm1Mpe	B6.Cg-Apcs^tm1Mpe	MGI:3775456
hm3	Apcs^tm1Mpe/Apcs^tm1Mpe	involves: 129/Sv * C57BL/6	MGI:2174730
ht4	Apcs^tm1Mpe/Apcs^+	B6.Cg-Apcs^tm1Mpe	MGI:3775476

Genotype
MGI:3775457

hm1

• Allelic Composition: Apcs^tm1Mpe/Apcs^tm1Mpe
• Genetic Background: 129.Cg-Apcs^tm1Mpe

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:125473 )

• mice exhibit decreased mortality when infected with S. pyogenes

increased susceptibility to bacterial infection induced morbidity/mortality ( J:125473 )

• mice exhibit increased mortality when infected with E. coli compared to wild-type mice

immune system

immune system phenotype ( J:90502 )

N • Background Sensitivity: unlike mice on a C56BL/6 background, mice on a 129 background do not develop increased autoimmune antibodies spontaneously or following induction by active immunization

glomerulonephritis ( J:90502 )

• infrequent and moderate

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:125473 )

• mice exhibit decreased mortality when infected with S. pyogenes

increased susceptibility to bacterial infection induced morbidity/mortality ( J:125473 )

• mice exhibit increased mortality when infected with E. coli compared to wild-type mice

renal/urinary system

glomerulonephritis ( J:90502 )

• infrequent and moderate

Genotype
MGI:3775456

hm2

• Allelic Composition: Apcs^tm1Mpe/Apcs^tm1Mpe
• Genetic Background: B6.Cg-Apcs^tm1Mpe

mortality/aging

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:125473 )

• mice exhibit increased survival when infected with rough E. coli J5 strain

increased susceptibility to bacterial infection induced morbidity/mortality ( J:125473 )

• mice exhibit increased susceptibility to infected with E. coli compared to wild-type mice

• treatment of mice with 10 mg/kg LPS exhibit accelerated mortality compared to wild-type mice

immune system

abnormal spleen morphology ( J:90502 )

abnormal spleen red pulp morphology ( J:90502 )

• mice exhibit red pulp lymphocytosis

abnormal spleen white pulp morphology ( J:90502 )

• mice exhibit coalescence of white pulp

increased spleen white pulp amount ( J:90502 )

increased autoantibody level ( J:90502 )

• with females more affected

glomerulonephritis ( J:90502 )

• mice, particularly females, exhibit a higher frequency and severity of proliferative, immune complex glomerulonephritis compared to wild-type and heterozygous mice

decreased susceptibility to bacterial infection ( J:125473 )

• mice exhibit greater killing of E. coli J5 strain than wild-type mice

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:125473 )

• mice exhibit increased survival when infected with rough E. coli J5 strain

increased susceptibility to bacterial infection induced morbidity/mortality ( J:125473 )

• mice exhibit increased susceptibility to infected with E. coli compared to wild-type mice

• treatment of mice with 10 mg/kg LPS exhibit accelerated mortality compared to wild-type mice

renal/urinary system

abnormal kidney morphology ( J:90502 )

glomerulonephritis ( J:90502 )

• mice, particularly females, exhibit a higher frequency and severity of proliferative, immune complex glomerulonephritis compared to wild-type and heterozygous mice

renal glomerular immunoglobulin deposits ( J:90502 )

hematopoietic system

abnormal spleen morphology ( J:90502 )

abnormal spleen red pulp morphology ( J:90502 )

• mice exhibit red pulp lymphocytosis

abnormal spleen white pulp morphology ( J:90502 )

• mice exhibit coalescence of white pulp

increased spleen white pulp amount ( J:90502 )

Genotype
MGI:2174730

hm3

• Allelic Composition: Apcs^tm1Mpe/Apcs^tm1Mpe
• Genetic Background: involves: 129/Sv * C57BL/6

normal phenotype

no abnormal phenotype detected ( J:42137 )

• normal development and fertility; no obvious defect detected up to 11 months of age

• resistance to induction of reactive amyloidosis

Genotype
MGI:3775476

ht4

• Allelic Composition: Apcs^tm1Mpe/Apcs⁺
• Genetic Background: B6.Cg-Apcs^tm1Mpe

immune system

abnormal spleen red pulp morphology ( J:90502 )

• mice exhibit red pulp lymphocytosis

abnormal spleen white pulp morphology ( J:90502 )

• mice exhibit coalescence of white pulp

increased spleen white pulp amount ( J:90502 )

increased autoantibody level ( J:90502 )

• intermediate increase with females more affected

glomerulonephritis ( J:90502 )

• mice, particularly females, exhibit intermediate frequency of proliferative, immune complex glomerulonephritis compared to wild-type mice

renal/urinary system

glomerulonephritis ( J:90502 )

• mice, particularly females, exhibit intermediate frequency of proliferative, immune complex glomerulonephritis compared to wild-type mice

renal glomerular immunoglobulin deposits ( J:90502 )

hematopoietic system

abnormal spleen red pulp morphology ( J:90502 )

• mice exhibit red pulp lymphocytosis

abnormal spleen white pulp morphology ( J:90502 )

• mice exhibit coalescence of white pulp

increased spleen white pulp amount ( J:90502 )