Analysis Tools
mortality/aging
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• mice die within the first day after birth
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nervous system
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• not clearly observed
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• at the caudate-putamen level
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• enlarged 60% to 70% and closed
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• the corpus callosum is interrupted at the caudate-putamen level and contains an unusual number of cell bodies unlike in wild-type mice
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• at E19, the hippocampus lacks normal laminar organization with pyramidal neurons scattered and separated unlike in wild-type mice
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• the dentate gyrus lacks cell organization unlike in wild-type mice
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• unlike in wild-type mice, the neuronal cell lamination of the cerebral cortex is lost and there is an unusual number of cell bodies in the corpus callosum
• the thickness of cortical region is varied unlike in wild-type mice
• in some mice the cerebral cortex is half the size as in wild-type mice
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• disorganized layers
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• at E19, the wide band of Purkinje cells normally present is absent
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behavior/neurological
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• on limbs
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