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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cdh5tm1Pec
targeted mutation 1, Peter Carmeliet
MGI:2148547
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cdh5tm1Pec/Cdh5tm1Pec Not Specified MGI:3790057


Genotype
MGI:3790057
hm1
Allelic
Composition
Cdh5tm1Pec/Cdh5tm1Pec
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdh5tm1Pec mutation (0 available); any Cdh5 mutation (59 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• at E9 and 9.5 vasculature of placenta disintegrates
• embryonic endothelial cells invade the chorion but fail to penetrate the trophoblast layer and do not establish close interactions with maternal sinuses
• placentas of mutants fail to develop past E8.75, contain only spongiotrophoblast but not labyrinth zone and remain much thinner than wild-type
• endothelial cells form channels that begin to disconnect from each other at their branches
• at E9 and 9.5 vasculature of yolk sac disintegrates
• at E9.5 endothelial cells disappear in vitelline vessels
• embryos do not progress beyond E8.75-9 developmental stage
• at E9, mutants have fewer somites than wild-type embryos

cardiovascular system
• sprouting of intersomitic vessels is impaired
• at E9 and 9.5 vasculature of placenta disintegrates
• embryonic endothelial cells invade the chorion but fail to penetrate the trophoblast layer and do not establish close interactions with maternal sinuses
• placentas of mutants fail to develop past E8.75, contain only spongiotrophoblast but not labyrinth zone and remain much thinner than wild-type
• endocardial cells detach from each other and are scattered in ventricular cavity
• beyond E8.75-9, endothelial cells throughout the vasculature progressively become disconnected from each other and exhibit gaps, detach from their basement membrane, and become scattered inside lumen
• remodeling of intersomitic vessels into network of large and small branches is impaired in embryos
• vasculature at E9 and 9.25 disintegrates
• at E9.5 cephalic vessels are dilated
• by E8.5, some blood vessels (thoracic dorsal aorta, anterior cardinal vein) in mutants have a minimal or no lumen while others are dilated (cephalic vessels)
• sprouting of intersomitic vessels is impaired
• endothelial cells form channels that begin to disconnect from each other at their branches
• at E9 and 9.5 vasculature of yolk sac disintegrates
• at E9.5 endothelial cells disappear in vitelline vessels
• scattered disconnected endocardial cells and a loosely assembled myocardium that is detached lie scattered in center of outflow tract and occlude the ventricular lumen at E8.75
• looping is initiated normally but development is retarded by E9.5

craniofacial

hematopoietic system
N
• hematopoiesis is not significantly impaired in mutants

cellular
• endothelial cells in mutants show impaired survival and elevated apoptosis relative to wild-type cells in vivo and in culture





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory