Phenotypes associated with this allele

• Allele Symbol: Cdh5^tm2Pec
• Allele Name: targeted mutation 2, Peter Carmeliet
• Allele ID: MGI:2148549
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdh5^tm2Pec/Cdh5^tm2Pec	Not Specified	MGI:3790058

Genotype
MGI:3790058

hm1

• Allelic Composition: Cdh5^tm2Pec/Cdh5^tm2Pec
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:56509 )

• embryos die at E9.5-10

embryo

abnormal placenta vasculature ( J:56509 )

• at E9 and 9.5 vasculature of placenta disintegrates

• embryonic endothelial cells invade the chorion but fail to penetrate the trophoblast layer and do not establish close interactions with maternal sinuses

• placentas of mutants fail to develop past E8.75, contain only spongiotrophoblast but not labyrinth zone and remain much thinner than wild-type

abnormal vitelline vasculature morphology ( J:56509 )

• endothelial cells form channels that begin to disconnect from each other at their branches

• at E9 and 9.5 vasculature of yolk sac disintegrates

• at E9.5 endothelial cells disappear in vitelline vessels

small pharyngeal arch ( J:56509 )

embryonic growth arrest ( J:56509 )

• embryos do not progress beyond E8.75-9 developmental stage

abnormal somite development ( J:56509 )

• at E9, mutants have fewer somites than wild-type embryos

cardiovascular system

abnormal intersomitic vessel morphology ( J:56509 )

• sprouting of intersomitic vessels is impaired

abnormal placenta vasculature ( J:56509 )

• at E9 and 9.5 vasculature of placenta disintegrates

• embryonic endothelial cells invade the chorion but fail to penetrate the trophoblast layer and do not establish close interactions with maternal sinuses

• placentas of mutants fail to develop past E8.75, contain only spongiotrophoblast but not labyrinth zone and remain much thinner than wild-type

abnormal vascular development ( J:56509 )

• endocardial cells detach from each other and are scattered in ventricular cavity

• beyond E8.75-9, endothelial cells throughout the vasculature progressively become disconnected from each other and exhibit gaps, detach from their basement membrane, and become scattered inside lumen

abnormal angiogenesis ( J:56509 )

• remodeling of intersomitic vessels into network of large and small branches is impaired in embryos

• vasculature at E9 and 9.25 disintegrates

abnormal vein development ( J:56509 )

• at E9.5 cephalic vessels are dilated

abnormal vascular endothelial cell development ( J:56509 )

abnormal vasculogenesis ( J:56509 )

• by E8.5, some blood vessels (thoracic dorsal aorta, anterior cardinal vein) in mutants have a minimal or no lumen while others are dilated (cephalic vessels)

• sprouting of intersomitic vessels is impaired

abnormal vitelline vasculature morphology ( J:56509 )

• endothelial cells form channels that begin to disconnect from each other at their branches

• at E9 and 9.5 vasculature of yolk sac disintegrates

• at E9.5 endothelial cells disappear in vitelline vessels

abnormal cardiac outflow tract development ( J:56509 )

• scattered disconnected endocardial cells and a loosely assembled myocardium that is detached lie scattered in center of outflow tract and occlude the ventricular lumen at E8.75

delayed heart development ( J:56509 )

• looping is initiated normally but development is retarded by E9.5

craniofacial

small pharyngeal arch ( J:56509 )

hematopoietic system

hematopoietic system phenotype ( J:56509 )

N • hematopoiesis is not significantly impaired in mutants

cellular

increased apoptosis ( J:56509 )

• endothelial cells in mutants show impaired survival and elevated apoptosis relative to wild-type cells in vivo and in culture