Phenotypes associated with this allele

• Allele Symbol: Ctnnb1^tm2.1Kem
• Allele Name: targeted mutation 2.1 Rolf Kemler
• Allele ID: MGI:2148569
• Summary: 22 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ctnnb1^tm2.1Kem/Ctnnb1^tm2.1Kem	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6	MGI:2674117
cn2	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Gt(ROSA)26Sor^tm1(Ctnnb1)Kem/Gt(ROSA)26Sor^+ Tg(Foxn1-cre)1Tbo/0	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6	MGI:5440185
cn3	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Gt(ROSA)26Sor^tm1(Ctnnb1)Kem/Gt(ROSA)26Sor^tm1(Ctnnb1)Kem Tg(Foxn1-cre)1Tbo/0	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6	MGI:5440184
cn4	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Gt(ROSA)26Sor^tm1(Ctnnb1)Kem/Gt(ROSA)26Sor^tm1.1(Ctnnb1)Kem Edil3^Tg(Sox2-cre)1Amc/Edil3^+	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA	MGI:5440177
cn5	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Edil3^Tg(Sox2-cre)1Amc/Edil3^+	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA	MGI:5440178
cn6	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Gt(ROSA)26Sor^tm1(Ctnnb1)Kem/Gt(ROSA)26Sor^tm1(Ctnnb1)Kem Tg(Cdx1-cre)23Kem/0	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB	MGI:5440181
cn7	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Gt(ROSA)26Sor^tm1(Ctnnb1)Kem/Gt(ROSA)26Sor^+ Tg(Cdx1-cre)23Kem/0	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB	MGI:5440180
cn8	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Gt(ROSA)26Sor^tm1(Ctnnb1)Kem/Gt(ROSA)26Sor^+ Tg(Zp3-cre)93Knw/0	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J	MGI:5440176
cn9	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Tg(Zp3-cre)93Knw/0	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J	MGI:5440179
cn10	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Gt(ROSA)26Sor^tm1(Ctnnb1)Kem/Gt(ROSA)26Sor^+ H2az2^Tg(Wnt1-cre)11Rth/H2az2^+	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA/J	MGI:5440183
cn11	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Gt(ROSA)26Sor^tm1(Ctnnb1)Kem/Gt(ROSA)26Sor^tm1(Ctnnb1)Kem H2az2^Tg(Wnt1-cre)11Rth/H2az2^+	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA/J	MGI:5440182
cn12	Amhr2^tm3(cre)Bhr/Amhr2^+ Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ	MGI:5006680
cn13	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Tg(Foxn1-cre)1Tbo/0	involves: 129S1/Sv * 129X1/SvJ	MGI:5440186
cn14	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Kdr^tm1(cre)Sato/Kdr^+	involves: 129S1/Sv * 129X1/SvJ	MGI:3831190
cn15	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Tg(T-cre)1Lwd/0	involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6	MGI:5509195
cn16	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Tg(T-cre/ERT2)1Lwd/0	involves: 129S1/Sv * 129X1/SvJ * C3H/HeNcr * C57BL/6NCr	MGI:5509196
cn17	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Tg(Tek-cre)1Ywa/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:3710231
cn18	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Corin^tm2(cre)Bamo/Corin^+ Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor^+	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:4844104
cn19	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem H2az2^Tg(Wnt1-cre)11Rth/H2az2^+	involves: 129/Sv * C57BL/6 * CBA	MGI:2674120
cx20	Ctnnb1^tm2.1Kem/Ctnnb1^+ Sall4^Gt(W097E01)Flo/Sall4^+	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:3809920
cx21	Axin1^tm4Cos/Axin1^tm4Cos Ctnnb1^tm2.1Kem/Ctnnb1^+	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:3840269
cx22	Ctnnb1^tm2.1Kem/Ctnnb1^+ Otx2^tm1(Dkk1)Imat/Otx2^tm1(Dkk1)Imat	involves: 129/Sv * C57BL/6 * CBA	MGI:3612484

Genotype
MGI:2674117

hm1

• Allelic Composition: Ctnnb1^tm2.1Kem/Ctnnb1^tm2.1Kem
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:178971 )

embryonic lethality, complete penetrance ( J:67966 )

• homozygotes died at gastrulation

embryo

absent mesoderm ( J:178971 )

abnormal inner cell mass morphology ( J:67966 )

• cell adhesion defect

Genotype
MGI:5440185

cn2

• Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem; Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}/Gt(ROSA)26Sor⁺; Tg(Foxn1-cre)1Tbo/0
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

integument

integument phenotype ( J:187739 )

N • skin lesions are not seen unlike in mutant mice lacking Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}

focal hair loss ( J:187739 )

• broad stripes of hair loss are seen

• loss is followed by regrowth

growth/size/body

decreased body size ( J:187739 )

• at P14; however, mice catch up with littermate controls with age

Genotype
MGI:5440184

cn3

• Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem; Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}/Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}; Tg(Foxn1-cre)1Tbo/0
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

integument

integument phenotype ( J:187739 )

N • skin lesions are not seen unlike in mutant mice lacking Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}

sparse hair ( J:187739 )

• thinner but continuous coat

growth/size/body

decreased body size ( J:187739 )

• at P14; however, mice catch up with littermate controls with age

Genotype
MGI:5440177

cn4

• Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem; Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}/Gt(ROSA)26Sor^{tm1.1(Ctnnb1)Kem}; Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA

mortality/aging

prenatal lethality, complete penetrance ( J:187739 )

embryo

abnormal germ layer development ( J:187739 )

• at E8.5 embryos have a sac-like structure composed of 2 layers where the outer layer is reminiscent of the visceral endoderm and the inner layer has characteristics of a pseudostratified epithelium

failure to gastrulate ( J:187739 )

• expression analysis indicates failure to gastrulate

abnormal embryonic tissue morphology ( J:187739 )

• formation of proper embryonic structures is incomplete

Genotype
MGI:5440178

cn5

• Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem; Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA

mortality/aging

prenatal lethality, complete penetrance ( J:187739 )

embryo

abnormal embryonic tissue morphology ( J:187739 )

• absence of embryonic structures at E8.5

Genotype
MGI:5440181

cn6

• Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem; Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}/Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}; Tg(Cdx1-cre)23Kem/0
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB

mortality/aging

perinatal lethality, complete penetrance ( J:187739 )

• develop until birth but do not survive

embryo

embryo phenotype ( J:187739 )

N • at E9.5 the length of tail buds are similar to controls

abnormal neural tube morphology ( J:187739 )

• abnormally folded distally at E9.5

open neural tube ( J:187739 )

renal/urinary system

persistent cloaca ( J:187739 )

• at E14.5

small kidney ( J:187739 )

• at E14.5

reproductive system

persistent cloaca ( J:187739 )

• at E14.5

abnormal sex gland morphology ( J:187739 )

• small gonads at E14.5

limbs/digits/tail

abnormal digit morphology ( J:187739 )

• deformed shortened forelimb digits vertebrae at E18.5

fused phalanges ( J:187739 )

• at E18.5

brachydactyly ( J:187739 )

• at E18.5

abnormal hindlimb morphology ( J:187739 )

• at E18.5 in rare cases some rudimentary upper hindlimb bones are present

absent hindlimb ( J:187739 )

• at E14.5

absent tail ( J:187739 )

• at E14.5

skeleton

fused phalanges ( J:187739 )

• at E18.5

abnormal rib morphology ( J:187739 )

• deformed shortened fused ribs at E18.5

rib fusion ( J:187739 )

• at E18.5

short ribs ( J:187739 )

• at E18.5

abnormal vertebrae morphology ( J:187739 )

• deformed shortened fused vertebrae at E18.5

small vertebrae ( J:187739 )

• at E18.5

vertebral fusion ( J:187739 )

• at E18.5

digestive/alimentary system

persistent cloaca ( J:187739 )

• at E14.5

nervous system

abnormal neural tube morphology ( J:187739 )

• abnormally folded distally at E9.5

open neural tube ( J:187739 )

endocrine/exocrine glands

small adrenal glands ( J:187739 )

• at E14.5

abnormal sex gland morphology ( J:187739 )

• small gonads at E14.5

Genotype
MGI:5440180

cn7

• Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem; Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}/Gt(ROSA)26Sor⁺; Tg(Cdx1-cre)23Kem/0
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB

mortality/aging

prenatal lethality, complete penetrance ( J:187739 )

embryo

caudal body truncation ( J:187739 )

• at E14.5 embryos consist of a head attached to internal organs including lung, liver and intestine while the urogenital system and mesoderm-derived tissues making up the body wall are highly underdeveloped or absent

truncated tail bud ( J:187739 )

• truncated tail bud region at E9.5

limbs/digits/tail

truncated tail bud ( J:187739 )

• truncated tail bud region at E9.5

Genotype
MGI:5440176

cn8

• Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem; Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}/Gt(ROSA)26Sor⁺; Tg(Zp3-cre)93Knw/0
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

mortality/aging

prenatal lethality, complete penetrance ( J:187739 )

embryo

abnormal germ layer development ( J:187739 )

• at E8.5 embryos have a sac-like structure composed of 2 layers where the outer layer is reminiscent of the visceral endoderm and the inner layer has characteristics of a pseudostratified epithelium

failure to gastrulate ( J:187739 )

• expression analysis indicates failure to gastrulate

abnormal embryonic tissue morphology ( J:187739 )

• formation of proper embryonic structures is incomplete

Genotype
MGI:5440179

cn9

• Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem; Tg(Zp3-cre)93Knw/0
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

mortality/aging

prenatal lethality, complete penetrance ( J:187739 )

embryo

abnormal embryonic tissue morphology ( J:187739 )

• absence of embryonic structures at E8.5

Genotype
MGI:5440183

cn10

• Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem; Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}/Gt(ROSA)26Sor⁺; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA/J

mortality/aging

prenatal lethality, complete penetrance ( J:187739 )

nervous system

abnormal brain morphology ( J:187739 )

• brain defects

craniofacial

abnormal craniofacial morphology ( J:187739 )

• impaired morphogenesis of craniofacial structures

Genotype
MGI:5440182

cn11

• Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem; Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}/Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA/J

mortality/aging

neonatal lethality, complete penetrance ( J:187739 )

• die within hours of birth probably because of an inability to feed

Genotype
MGI:5006680

cn12

• Allelic Composition: Amhr2^tm3(cre)Bhr/Amhr2⁺; Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem
• Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

reproductive system

abnormal sex determination ( J:171430 )

• newborn males have both male and female reproductive tracts

embryo

abnormal Mullerian duct morphology ( J:171430 )

• mesenchyme is less condensed

failure of Mullerian duct regression ( J:171430 )

• decrease in apoptosis in the epithelium

Genotype
MGI:5440186

cn13

• Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem; Tg(Foxn1-cre)1Tbo/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

mortality/aging

neonatal lethality, complete penetrance ( J:187739 )

• due to skin lesions

integument

skin lesions ( J:187739 )

Genotype
MGI:3831190

cn14

• Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem; Kdr^tm1(cre)Sato/Kdr⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:142352 )

• all embryos die by E12.5 due to severe hemorrhaging within the central nervous system

cardiovascular system

abnormal vasculogenesis ( J:142352 )

• in E12.5 embryos, endothelial cells and pericytes are entirely absent from the neuroepithelium

intracranial hemorrhage ( J:142352 )

• hemorrhaging is detected throughout the developing brain of E12.5 embryos

spinal hemorrhage ( J:142352 )

• hemorrhaging is detected throughout the developing spine of E12.5 embryos

abnormal blood-brain barrier function ( J:142352 )

• hemorrhaging and downregulation of the endothelial marker GLUT-1 suggest a defect in the blood brain barrier of developing embryos

nervous system

intracranial hemorrhage ( J:142352 )

• hemorrhaging is detected throughout the developing brain of E12.5 embryos

spinal hemorrhage ( J:142352 )

• hemorrhaging is detected throughout the developing spine of E12.5 embryos

abnormal blood-brain barrier function ( J:142352 )

• hemorrhaging and downregulation of the endothelial marker GLUT-1 suggest a defect in the blood brain barrier of developing embryos

Genotype
MGI:5509195

cn15

• Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem; Tg(T-cre)1Lwd/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

embryo

caudal body truncation ( J:200549 )

• severely truncated at E8.5

abnormal somite development ( J:200549 )

• at E8.5, somites are disorganized

Genotype
MGI:5509196

cn16

• Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem; Tg(T-cre/ERT2)1Lwd/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeNcr * C57BL/6NCr

embryo

caudal body truncation ( J:200549 )

• with tamoxifen administration at E6.5, E8.5 embryos phenocopy the caudal body truncation seen with constitutive T-cre mediated inactivation

abnormal axial mesoderm morphology ( J:200549 )

• with tamoxifen administration at E8.5, E10.5 embryos show defects in depletion of pre-somitic mesoderm (PSM) and segmentation defects, similar to embryos at E8.5

abnormal somite development ( J:200549 )

• with tamoxifen administration at E6.5 or E8.5, E8.5 and E10.5 embryos show disruption of somite patterning

Genotype
MGI:3710231

cn17

• Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem; Tg(Tek-cre)1Ywa/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:85505 )

• 50% die by E11.5 and 100% die by E13.5

cardiovascular system

abnormal blood vessel morphology ( J:85505 )

• in the head, the vascular network is less organized, with vessels of irregular diameter and shape and often blind ending vessels and lacunae-like bifurcations are observed

• cephalic vessels show an inconstant diameter and often form acute turns and branching

abnormal vascular endothelial cell morphology ( J:85505 )

• endocardial and vascular endothelial cells are more elongated, resulting in a continuously thinner endothelial layer

• endothelial cells present a higher degree of fenestration; these structures are discontinuities in the cell membranes

• endothelial cells have altered intercellular junctional organization, with thinner and longer bundles of actin filaments

abnormal placental labyrinth vasculature morphology ( J:85505 )

• the labyrinthine layer is less vascularized, there is a reduction in the number of fetal blood vessels that penetrate into the labyrinthine area and they remain concentrated in the chorionic plate

abnormal vitelline vasculature morphology ( J:85505 )

• vitelline vessels have a smaller diameter

• however, the primary vascular plexus is present and correctly organized

abnormal endocardium morphology ( J:85505 )

• thin endocardium

small heart ( J:85505 )

pericardial edema ( J:85505 )

• frequently have extensive liquid accumulation in the pericardial cavity

hemorrhage ( J:85505 )

• about 50% of embryos have hemorrhages in different vascular areas such as the head and the dorsal vessels

embryo

abnormal vitelline vasculature morphology ( J:85505 )

• vitelline vessels have a smaller diameter

• however, the primary vascular plexus is present and correctly organized

abnormal placenta morphology ( J:85505 )

abnormal placental labyrinth vasculature morphology ( J:85505 )

• the labyrinthine layer is less vascularized, there is a reduction in the number of fetal blood vessels that penetrate into the labyrinthine area and they remain concentrated in the chorionic plate

thin placenta labyrinth ( J:85505 )

• reduced in thickness

abnormal umbilical cord blood vessel morphology ( J:85505 )

• umbilical vessels are often increased in number, have a smaller diameter and are abnormally branched or anastomosed

abnormal visceral yolk sac morphology ( J:85505 )

pale yolk sac ( J:85505 )

• seen at E10.5 but not E8.5

homeostasis/metabolism

pericardial edema ( J:85505 )

• frequently have extensive liquid accumulation in the pericardial cavity

Genotype
MGI:4844104

cn18

• Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem; Corin^tm2(cre)Bamo/Corin⁺; Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

integument

abnormal auchene hair morphology ( J:160311 )

• auchene growth is terminated before formation of the single bend unlike in wild-type mice

• however, the first segment is normal

abnormal awl hair morphology ( J:160311 )

• shorter, thinner, and more numerous than in wild-type mice

decreased guard hair length ( J:160311 )

abnormal hair shaft morphology ( J:160311 )

• at the end of the first hair cycle, all hairs are shorter and thinner than in wild-type mice

abnormal zigzag hair morphology ( J:160311 )

• the first segment of zigzag hairs is variable in length from 60% to 100% of wild-type hair length

• the second segment is reduced in length 50% to 60% compared to in wild-type mice

• the first and second segments are thinner than in wild-type mice

• zigzag hairs lack the third and fourth segment unlike in wild-type mice

abnormal hair cycle anagen phase ( J:160311 )

• duration of anagen is decreased compared to in wild-type mice

• hair follicles enter catagen prematurely compared to in wild-type mice

abnormal hair cycle catagen phase ( J:160311 )

• catagen onset occurs at P12 and is less synchronized than in wild-type mice

abnormal hair cycle telogen phase ( J:160311 )

• telogen begins earlier than in wild-type mice

delayed hair regrowth ( J:160311 )

• 40 days after depilation, only sparse hair regenerate unlike in similarly treated wild-type mice

abnormal hair follicle physiology ( J:160311 )

• proliferation of matrix progenitor cells abutting the dermal papilla (MPADs) and their progeny is reduced compared to in wild-type mice

• mice fail to exhibit normal hair follicle regeneration compared with wild-type mice

increased hair follicle apoptosis ( J:160311 )

• the number of apoptotic cells averaged over all follicles is increased

cellular

increased hair follicle apoptosis ( J:160311 )

• the number of apoptotic cells averaged over all follicles is increased

Genotype
MGI:2674120

cn19

• Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: 129/Sv * C57BL/6 * CBA

mortality/aging

prenatal lethality, complete penetrance ( J:67966 )

• no mutant mice are born

craniofacial

absent craniofacial bones ( J:67966 )

• craniofacial bones derived from neural crest cells are absent

• bones present include optic vesicle, basioccipital, exoccipital

skeleton

absent craniofacial bones ( J:67966 )

• craniofacial bones derived from neural crest cells are absent

• bones present include optic vesicle, basioccipital, exoccipital

nervous system

abnormal neural tube morphology ( J:67966 )

• shortened neural tube

abnormal brain morphology ( J:67966 )

abnormal brain development ( J:67966 )

• brain morphogenesis grossly abnormal between E10.5 and 18.5

absent midbrain-hindbrain boundary ( J:67966 )

• isthmic border between midbrain and rhombencephalon not visible

absent choroid plexus ( J:67966 )

• choroid plexus absent by E12.5

abnormal trigeminal V mesencephalic nucleus morphology ( J:67966 )

• indistinctly formed

absent midbrain ( J:67966 )

• by E10.5 parts of the midbrain are missing

• no discernable midbrain by E12.5

abnormal telencephalon morphology ( J:67966 )

• enlarged telencephalon

• walls of cephalic vesicles thinner

abnormal hindbrain morphology ( J:67966 )

• anterior hindbrain is missing by E10.5

• poorly formed connections between cranial ganglia and hindbrain

absent cerebellum ( J:67966 )

• cerebellum is missing at E12.5

absent metencephalon ( J:67966 )

• anterior hindbrain is missing by E10.5

abnormal cranial nerve morphology ( J:67966 )

abnormal facial nerve morphology ( J:67966 )

• combined ganglion with vestibulocochlear nerve abnormal

abnormal glossopharyngeal nerve morphology ( J:67966 )

• roots poorly formed

abnormal hypoglossal nerve morphology ( J:67966 )

• roots poorly formed

• hypoglossal nerve missing

absent oculomotor nerve ( J:67966 )

abnormal vagus nerve morphology ( J:67966 )

• roots poorly formed

abnormal dorsal root ganglion morphology ( J:67966 )

• first spinal root ganglion missing

• other spinal root ganglia severely affected as well

embryo

abnormal neural tube morphology ( J:67966 )

• shortened neural tube

Genotype
MGI:3809920

cx20

• Allelic Composition: Ctnnb1^tm2.1Kem/Ctnnb1⁺; Sall4^{Gt(W097E01)Flo}/Sall4⁺
• Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

mortality/aging

preweaning lethality, complete penetrance ( J:138922 )

• absent at weaning possibly indicating embryonic lethality

embryo

abnormal mesoderm development ( J:138922 )

• expression analysis indicates impaired mesoderm development

embryonic growth retardation ( J:138922 )

• at E7.5

abnormal anterior primitive streak morphology ( J:138922 )

• a gap in T expression is seen in the anterior primitive streak between E7.5 and E7.75 in the area where cells fate mapped to give rise to paraxial mesoderm are found

growth/size/body

embryonic growth retardation ( J:138922 )

• at E7.5

Genotype
MGI:3840269

cx21

• Allelic Composition: Axin1^tm4Cos/Axin1^tm4Cos; Ctnnb1^tm2.1Kem/Ctnnb1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

mortality/aging

mortality/aging ( J:147293 )

N • unlike Axin1^tm4Cos homozygotes, mice survive until E18.5 when they are sacrificed

craniofacial

abnormal facial morphology ( J:147293 )

cleft palate ( J:147293 )

abnormal nose morphology ( J:147293 )

• mice lack nasal structures unlike wild-type mice

respiratory system

abnormal nose morphology ( J:147293 )

• mice lack nasal structures unlike wild-type mice

nervous system

abnormal brain morphology ( J:147293 )

• mice have multiple brain malformations unlike wild-type mice

digestive/alimentary system

cleft palate ( J:147293 )

growth/size/body

abnormal head morphology ( J:147293 )

abnormal facial morphology ( J:147293 )

cleft palate ( J:147293 )

abnormal nose morphology ( J:147293 )

• mice lack nasal structures unlike wild-type mice

Genotype
MGI:3612484

cx22

• Allelic Composition: Ctnnb1^tm2.1Kem/Ctnnb1⁺; Otx2^{tm1(Dkk1)Imat}/Otx2^{tm1(Dkk1)Imat}
• Genetic Background: involves: 129/Sv * C57BL/6 * CBA

embryo

abnormal rostral-caudal axis patterning ( J:103272 )

• based on expression of anterior visceral endoderm markers, the anterior migration defects of distal visceral endoderm cells observed in 6.5 p.d.c. Otx2^tm2/Otx2^tm2 embryo was partially rescued