Phenotypes associated with this allele

• Allele Symbol: Mpg^tm1Rhe
• Allele Name: targeted mutation 1, Rhoderick H Elder
• Allele ID: MGI:2148592
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mpg^tm1Rhe/Mpg^tm1Rhe	B6.129P2-Mpg^tm1Rhe	MGI:3851521
hm2	Mpg^tm1Rhe/Mpg^tm1Rhe	involves: 129P2/OlaHsd * C57BL/6J	MGI:3851520

Genotype
MGI:3851521

hm1

• Allelic Composition: Mpg^tm1Rhe/Mpg^tm1Rhe
• Genetic Background: B6.129P2-Mpg^tm1Rhe

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:86644 )

• slightly more resistant to liver tumor formation resulting from high doses of vinyl carbamide but not significant

increased physiological sensitivity to xenobiotic ( J:86644 )

• exposure to vinyl carbamade results in elevated and more persistent levels of 1,N⁶-ethenoadenine in both liver and lungs

neoplasm

decreased incidence of tumors by chemical induction ( J:86644 )

• slightly more resistant to liver tumor formation resulting from high doses of vinyl carbamide but not significant

Genotype
MGI:3851520

hm2

• Allelic Composition: Mpg^tm1Rhe/Mpg^tm1Rhe
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

homeostasis/metabolism

increased circulating glucose level ( J:70603 )

• mice are diabetic at 8 months following STZ treatment

enhanced lipolysis ( J:70603 )

• marked lipolysis in some mice at 8 months following STZ treatment

abnormal physiological response to xenobiotic ( J:70603 )

• beta cells of the pancreas respond to STZ by increased apoptosis rather than increased necrosis

increased physiological sensitivity to xenobiotic ( J:50033 )

• increased mutagenic effect of methyl methanesulfonate treatment

endocrine/exocrine glands

abnormal pancreatic islet cell apoptosis ( J:70603 )

• beta cells of the pancreas respond to STZ by increased apoptosis rather than increased necrosis

abnormal pancreatic beta cell physiology ( J:70603 )

• resistant to STZ induced decrease in pancreatic insulin

• severely reduced pancreatic insulin levels at 8 months following STZ treatment

adipose tissue

abnormal fat pad morphology ( J:70603 )

• some mice show greatly reduced fat pads at 8 months following STZ treatment

immune system

increased CD4-positive, alpha-beta T cell number ( J:70603 )

• marked CD4+ T cell proliferation

hematopoietic system

increased CD4-positive, alpha-beta T cell number ( J:70603 )

• marked CD4+ T cell proliferation

cellular

abnormal pancreatic islet cell apoptosis ( J:70603 )

• beta cells of the pancreas respond to STZ by increased apoptosis rather than increased necrosis