Analysis Tools|
Allele Symbol Allele Name Allele ID |
Ctnnb1tm4Wbm targeted mutation 4, Walter Birchmeier MGI:2148594 |
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| Summary |
12 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die shortly after birth
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• in newborns and when skin is grafted onto wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E14.5, ectopic muscle splitting and muscle mispatterning in both fore- and hindlimbs are observed, due to deletion of Tbx5 in muscle connective tissue cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• enhanced infiltration in the skin
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• decrease in gamma-delta TCR+ T cells (dendritic epidermal T cells) in the skin
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• enhanced infiltration in the skin
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• decrease in gamma-delta TCR+ T cells (dendritic epidermal T cells) in the skin
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Lack of hair follicles in Ctnnb1tm4Wbm/Ctnnb1+ Tg(KRT14-cre)1Efu/0 mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 40% of tamoxifen-treated male mice fail to develop a proper prepuce and ventral midline formation unlike wild-type mice
• however, development of female genital tracts is normal
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• 40% of tamoxifen-treated male mice fail to develop a proper prepuce unlike wild-type mice
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• 40% of tamoxifen-treated male mice fail to develop a proper prepuce unlike wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• proliferation of cells declined by E10
• 45% at E11 to 50% at E11.5
• E11 proliferation rate down 35%
• 4.8X increase in progenitor cell death and apoptosis
• higher proportion of differentiated neurons to proliferative cells
• number of neurons unchanged
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• changes similar to those seen in the spinal cord
• tissue mass of the midbrain was reduced
• progenitor domains in the midbrain and other areas of the brain reduced
• increased apoptosis
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• ventricular zone absent at E12
• reduced area occupied by progenitor cells
• ventral progenitor are absent by E11.5
• absent dorsally by E12
• Larger area occupied by differentiated neurons(as determined immunohistochemically and gene markers)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• hairless patches at 8 days of age
• hair placodes absent where Catnb is not expressed
• initial phase hair growth occurs until 16 days
• reduced number of zigzag hairs
• hair lost around 4 weeks of age and no regrowth
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no hairless skin patches at 8 days of age
• initial phase hair growth occurs until 16 days of age
• reduced number of zigzag hairs
• hair loss around 4 weeks of age and no regrowth
• hair shafts become separated from dermal papillae
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice are pre-disposed to developing nuclear cataracts as they age but otherwise have a normal eye phenotype
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E14.5, the lens capsule is thinner than in controls
• the anterior capsule is extremely thin, whereas the posterior capsule is abnormally thick and diffuse at 1 day of age
• the close adherence of the iris to the remaining abnormal epithelial cells is further evidence of an abnormal lens capsule at 1 day of age
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• at 21 days of age, abnormal fiber cells are surrounded by a very thin basement membrane that is often ruptured resulting in fiber cell extrusion into the vitreous and posterior chamber of the aqueous near the iris
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• the cell cycle of lens epithelial cells is disrupted by E13.5 with 3-fold less cells being in the S phase or M phase
• at E14.5, epithelium is thin with the presence of blood cells found under an abnormal multilayered epithelium
• at P1, the lens epithelium is thin and the epithelial cells abnormally shaped
• at P21, the residual lens has no distinguishable epithelium and a thin basement membrane
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• at E14.5, fiber cells displayed altered apical?basal polarity as evidenced by altered distribution of the tight junction protein, ZO1, disruption of apical actin filaments, and accumulations of extracellular matrix containing collagen
• at P1, fiber cells are poorly elongated and tend to be aligned more perpendicularly to the capsule than parallel
• at P21, the abnormal fiber cells are often extruding into the vitreous
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• small lens size is discernable at 1 day of age and size is greatly reduced by 21 days of age
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• small eye phenotype is discernable at eye opening at 12 days of age with greatly reduced eye size evident by weaning
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• occurs in patches on the cheek by 21 days of age
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• occurs by 21 days of age
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm Tg(Pdx1-cre)6Tuv/? pancreata display extensive loss of exocrine tissue
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• shortened lifespan, with a median survival of 29 days, although some mice do survive more than 6 months
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• small body size at birth that persists into adulthood
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• in 17% of mutants that survived beyond 3 months, the pancreas has a liver-like histology
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• numerous tubular structures suggesting pancreas acinar to duct metaplasia, however islets are intact
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• acinar hypoplasia is seen by E16.5 and by 2 months of age, there is a near complete absence of acinar cell structures
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• pancreas weighs on average 30% less than wild-type
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• increase in parenchymal fibrosis
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• decrease in the proliferation rate of pancreatic exocrine progenitors
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• variable degree of surrounding inflammatory infiltrate which becomes more severe by 1 month of age; inflammatory infiltrate is reminiscent of pancreatitis
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• variable degree of surrounding inflammatory infiltrate which becomes more severe by 1 month of age; inflammatory infiltrate is reminiscent of pancreatitis
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• numerous tubular structures suggesting pancreas acinar to duct metaplasia, however islets are intact
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• acinar hypoplasia is seen by E16.5 and by 2 months of age, there is a near complete absence of acinar cell structures
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• neural tube defects are seen at mid gestation
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• neural tube defects are seen at mid gestation
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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